Jagiellonian University

About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.

Approved IFCC recommendation on reporting results for blood glucose

Abstract: In current clinical practice, plasma and blood glucose are used interchangeably with a consequent risk of clinical misinterpretation In human blood, glucose is distributed, like water, between erythrocytes and plasma The molality of glucose (amount of glucose per unit water mass) is the same throughout the sample, but the concentration is higher in plasma, because the concentration of water and therefore glucose is higher in plasma than in erythrocytes Different devices for the measurement of glucose may detect and report fundamentally different quantities Different water concentrations in the calibrator, plasma, and erythrocyte fluid can explain some of the differences Results for glucose measurements depend on the sample type and on whether the method requires sample dilution or uses biosensors in undiluted samples If the results are mixed up or used indiscriminately, the differences may exceed the maximum allowable error for glucose determinations for diagnosing and monitoring diabetes mellitus, thus complicating patient treatment The goal of the International Federation of Clinical Chemistry and Laboratory Medicine, Scientific Division, Working Group on Selective Electrodes and Point of Care Testing (IFCC-SD-WG-SEPOCT) is to reach a global consensus on reporting results The document recommends reporting the concentration of glucose in plasma (in the unit mmol/L), irrespective of sample type or measurement technique A constant factor of 111 is used to convert concentration in whole blood to the equivalent concentration in plasma The conversion will provide harmonized results, facilitating the classification and care of patients and leading to fewer therapeutic misjudgments

Factors associated with progression to macroalbuminuria in microalbuminuric Type 1 diabetic patients: the EURODIAB Prospective Complications Study

Abstract: Type 1 diabetic patients who develop microalbuminuria are clearly disadvantaged in terms of their risk of morbidity and mortality from renal and cardiovascular diseases. It is therefore important to identify potential factors that can predict progression to macroalbuminuria. This is a 7-year follow-up study of 352 microalbuminuric Type 1 diabetic patients from 31 European centres. Risk factors at baseline were compared in patients who progressed to macroalbuminuria and in patients who remained microalbuminuric or reverted to normoalbuminuria. Risk factors and albumin excretion rate (AER) were measured centrally. Over 7.3 years, 13.9% of the microalbuminuric patients progressed to macroalbuminuria, 35.5% remained microalbuminuric and 50.6% reverted to normoalbuminuria. Independent baseline risk factors for progression to macroalbuminuria were HbA1c (7.9% vs 6.8%, p=0.004), AER (64.4 vs 44.9 µg/min, p=0.0001) and—after adjusting for diabetes duration, HbA1c and AER—body weight (72 vs 67 kg, p=0.05). Independent factors associated with regression to normoalbuminuria were diabetes duration (15 vs 18 years, p=0.004), AER (37.2 vs 44.9 µg/min, p=0.0001) and—after adjusting for diabetes duration, HbA1c and AER—waist-to-hip ratio (0.83 vs 0.86, p=0.05) and incidence of peripheral neuropathy at baseline (24% vs 38%, p=0.001). Blood pressure and smoking did not emerge as risk factors at baseline for the outcome of microalbuminuria. A significant fraction of microalbuminuric Type 1 diabetic patients will progress to overt proteinuria. Patients with higher AER values, sub-optimal metabolic control, excess body fat and peripheral neuropathy may carry a particularly high risk of clinical nephropathy requiring aggressive therapeutic intervention.

The evolution of active galactic nuclei and their spins

Abstract: Massive black holes (MBHs), in contrast to stellar mass black holes, are expected to substantially change their properties over their lifetime. MBH masses increase by several orders of magnitude over a Hubble time, as illustrated by Soltan's argument. MBH spins also must evolve through the series of accretion and mergers events that increase the masses of MBHs. We present a simple model that traces the joint evolution of MBH masses and spins across cosmic time. Our model includes MBH-MBH mergers, merger-driven gas accretion, stochastic fueling of MBHs through molecular cloud capture, and a basic implementation of accretion of recycled gas. This approach aims at improving the modeling of low-redshift MBHs and active galactic nuclei (AGNs), whose properties can be more easily estimated observationally. Despite the simplicity of the model, it does a good job capturing the global evolution of the MBH population from z ~ 6 to today. Under our assumptions, we find that the typical spin and radiative efficiency of MBHs decrease with cosmic time because of the increased incidence of stochastic processes in gas-rich galaxies and MBH-MBH mergers in gas-poor galaxies. At z = 0, the spin distribution in gas-poor galaxies peaks at spins 0.4-0.8 and is not strongly mass dependent. MBHs in gas-rich galaxies have a more complex evolution, with low-mass MBHs at low redshift having low spins and spins increasing at larger masses and redshifts. We also find that at z > 1 MBH spins are on average the highest in high luminosity AGNs, while at lower redshifts these differences disappear.

Patients with COVID-19: in the dark-NETs of neutrophils.

Abstract: SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs, occasionally causing death. Until effective vaccines are developed to curb the pandemic, it is paramount to define the mechanisms and develop protective therapies to prevent organ dysfunction in patients with COVID-19. Individuals that develop severe manifestations have signs of dysregulated innate and adaptive immune responses. Emerging evidence implicates neutrophils and the disbalance between neutrophil extracellular trap (NET) formation and degradation plays a central role in the pathophysiology of inflammation, coagulopathy, organ damage, and immunothrombosis that characterize severe cases of COVID-19. Here, we discuss the evidence supporting a role for NETs in COVID-19 manifestations and present putative mechanisms, by which NETs promote tissue injury and immunothrombosis. We present therapeutic strategies, which have been successful in the treatment of immunο-inflammatory disorders and which target dysregulated NET formation or degradation, as potential approaches that may benefit patients with severe COVID-19.

Catalytic asymmetric aldol reactions in aqueous media – a 5 year update

Abstract: Asymmetric reactions in water and in aqueous solutions have become an area of fast growing interest recently. Although for a long time neglected as a medium for organic reactions, water has attracted attention as the most widely distributed solvent in the world. Indeed, water is the solvent used by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeogenesis and related processes. Consequently, artificial catalysts designed and used for aldol reactions in water can be promising for the synthesis of enantiopure molecules and are also important for the understanding of complex chemistry of life. This tutorial review summarizes recent developments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions – development of water compatible chiral Lewis acids and amine-based organocatalysts.