Jagiellonian University

About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.

Fibrin Clot Structure and Function A Role in the Pathophysiology of Arterial and Venous Thromboembolic Diseases

Abstract: The formation of fibrin clots that are relatively resistant to lysis represents the final step in blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in relation to thrombotic disease. In addition, we discuss the implications of fibrin structure for treatment of thrombosis. Fibrin clots composed of compact, highly branched networks with thin fibers are resistant to lysis. Altered fibrin structure has consistently been reported in patients with several diseases complicated by thromboembolic events, including patients with acute or prior myocardial infarction, ischemic stroke, and venous thromboembolism. Relatives of patients with myocardial infarction or venous thromboembolism display similar fibrin abnormalities. Low-dose aspirin, statins, lowering of homocysteine, better diabetes control, smoking cessation, and suppression of inflammatory response increase clot permeability and susceptibility to lysis. Growing evidence indicates that abnormal fibrin properties represent a novel risk factor for arterial and venous thrombotic events, particularly of unknown etiology in young and middle-aged patients.

Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe

Abstract: Background: The prevalence of asthma and its association with chronic rhinosinusitis (CRS) have not been widely studied in population-based epidemiological surveys. Methods: The Global Allergy and ...

Natural orbitals for chemical valence as descriptors of chemical bonding in transition metal complexes

Abstract: Natural orbitals for chemical valence (NOCV) are defined as the eigenvectors of the chemical valence operator defined by Nalewajski et al.; they decompose the deformation density (differential density, Deltarho) into diagonal contributions. NOCV were used in a description of the chemical bond between the organometallic fragment and the ligand in example transition-metal complexes: heme-CO ([FeN(5)C(20)H(15)]-CO), [Ni-diimine hydride]-ethylene ([N;N-Ni-H]-C(2)H(4), N;N = -NH-CH-CH-NH-), and [Ni(NH(3))(3)]-CO. DFT calculations were performed using gradient-corrected density functional theory (DFT) in the fragments resolution, using the fragment/ligand Kohn-Sham orbitals as a basis set in calculations for the whole fragment-ligand complex. It has been found that NOCV lead to a very compact description of the fragment-ligand bond, with only a few orbitals exhibiting non-zero eigenvalues. Results of NOCV analysis, compared with Mulliken populations analysis and Zigler-Rauk interaction-energy decomposition, demonstrate that the use of the natural valence orbitals allows for a separation of the sigma-donation and pi-back-donation contributions to the ligand-fragment bond. They can be also useful in comparison of these contributions in different complexes.

Prevalence, patterns and predictors of nursing care left undone in European hospitals: results from the multicountry cross-sectional RN4CAST study

Abstract: Background Little is known of the extent to which nursing-care tasks are left undone as an international phenomenon. Aim The aim of this study is to describe the prevalence and patterns of nursing care left undone across European hospitals and explore its associations with nurse-related organisational factors. Methods Data were collected from 33 659 nurses in 488 hospitals across 12 European countries for a large multicountry cross-sectional study. Results Across European hospitals, the most frequent nursing care activities left undone included ‘Comfort/talk with patients’ (53%), ‘Developing or updating nursing care plans/care pathways’ (42%) and ‘Educating patients and families’ (41%). In hospitals with more favourable work environments (B=−2.19; p<0.0001), lower patient to nurse ratios (B=0.09; p<0.0001), and lower proportions of nurses carrying out non-nursing tasks frequently (B=2.18; p<0.0001), fewer nurses reported leaving nursing care undone. Conclusions Nursing care left undone was prevalent across all European countries and was associated with nurse-related organisational factors. We discovered similar patterns of nursing care left undone across a cross-section of European hospitals, suggesting that nurses develop informal task hierarchies to facilitate important patient-care decisions. Further research on the impact of nursing care left undone for patient outcomes and nurse well-being is required.