Jagiellonian University

About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.

Large breasts and narrow waists indicate high reproductive potential in women

Abstract: Physical characteristics, such as breast size and waist-to-hip ratio (WHR), function as important features used by human males to assess female attractiveness. Males supposedly pay attention to these features because they serve as cues to fecundity and health. Here, we document that women with higher breastto-underbreast ratio (large breasts) and women with relatively low WHR (narrow waists) have higher fecundity as assessed by precise measurements of daily levels of 17-β-oestradiol (E2) and progesterone. Furthermore, women who are characterized by both narrow waists and large breasts have 26% higher mean E2 and 37% higher mean mid-cycle E2 levels than women from three groups with other combinations of body-shape variables, i.e. low WHR with small breasts and high WHR with either large or small breasts. Such gains in hormone levels among the preferred mates may lead to a substantial rise in the probability of conception, thus providing a significant fitness benefit.

A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages

Abstract: Although considered to be an extracellular pathogen, Staphylococcus aureus is able to invade a variety of mammalian, non-professional phagocytes and can also survive engulfment by professional phagocytes such as neutrophils and monocytes. In both of these cell types S. aureus promptly escapes from the endosomes/phagosomes and proliferates within the cytoplasm, which quickly leads to host cell death. In this report we show that S. aureus interacted with human monocyte-derived macrophages in a very different way to those of other mammalian cells. Upon phagocytosis by macrophages, S. aureus persisted intracellularly in vacuoles for 3–4 days before escaping into the cytoplasm and causing host cell lysis. Until the point of host cell lysis the infected macrophages showed no signs of apoptosis or necrosis and were functional. They were able to eliminate intracellular staphylococci if prestimulated with interferon-γ at concentrations equivalent to human therapeutic doses. S. aureus survival was dependent on the alternative sigma factor B as well as the global regulator agr, but not SarA. Furthermore, isogenic mutants deficient in α-toxin, the metalloprotease aureolysin, protein A, and sortase A were efficiently killed by macrophages upon phagocytosis, although with different kinetics. In particular α-toxin was a key effector molecule that was essential for S. aureus intracellular survival in macrophages. Together, our data indicate that the ability of S. aureus to survive phagocytosis by macrophages is determined by multiple virulence factors in a way that differs considerably from its interactions with other cell types. S. aureus persists inside macrophages for several days without affecting the viability of these mobile cells which may serve as vehicles for the dissemination of infection.

DC isoketal-modified proteins activate T cells and promote hypertension

Abstract: Oxidative damage and inflammation are both implicated in the genesis of hypertension; however, the mechanisms by which these stimuli promote hypertension are not fully understood. Here, we have described a pathway in which hypertensive stimuli promote dendritic cell (DC) activation of T cells, ultimately leading to hypertension. Using multiple murine models of hypertension, we determined that proteins oxidatively modified by highly reactive γ-ketoaldehydes (isoketals) are formed in hypertension and accumulate in DCs. Isoketal accumulation was associated with DC production of IL-6, IL-1β, and IL-23 and an increase in costimulatory proteins CD80 and CD86. These activated DCs promoted T cell, particularly CD8+ T cell, proliferation; production of IFN-γ and IL-17A; and hypertension. Moreover, isoketal scavengers prevented these hypertension-associated events. Plasma F2-isoprostanes, which are formed in concert with isoketals, were found to be elevated in humans with treated hypertension and were markedly elevated in patients with resistant hypertension. Isoketal-modified proteins were also markedly elevated in circulating monocytes and DCs from humans with hypertension. Our data reveal that hypertension activates DCs, in large part by promoting the formation of isoketals, and suggest that reducing isoketals has potential as a treatment strategy for this disease.

GeV observations of star-forming galaxies with the Fermi Large Area Telescope

Abstract: Recent detections of the starburst galaxies M82 and NGC 253 by gamma-ray telescopes suggest that galaxies rapidly forming massive stars are more luminous at gamma-ray energies compared to their quiescent relatives. Building upon those results, we examine a sample of 69 dwarf, spiral, and luminous and ultraluminous infrared galaxies at photon energies 0.1-100 GeV using 3 years of data collected by the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope (Fermi). Measured fluxes from significantly detected sources and flux upper limits for the remaining galaxies are used to explore the physics of cosmic rays in galaxies.We find further evidence for quasi-linear scaling relations between gamma-ray luminosity and both radio continuum luminosity and total infrared luminosity which apply both to quiescent galaxies of the Local Group and low-redshift starburst galaxies (conservative P-values 0.05 accounting for statistical and systematic uncertainties). The normalizations of these scaling relations correspond to luminosity ratios of log(L0.1-100 GeV/L1.4 GHz) = 1.7 ± 0.1(statistical) ± 0.2(dispersion) and log(L0.1-100 GeV/L8-1000μm) = −4.3 ± 0.1(statistical) ± 0.2(dispersion) for a galaxy with a star formation rate of 1M yr−1, assuming a Chabrier initial mass function. Using the relationship between infrared luminosity and gamma-ray luminosity, the collective intensity of unresolved star-forming galaxies at redshifts 0 < z < 2.5 above 0.1 GeV is estimated to be 0.4-2.4 ×10−6 ph cm−2 s−1 sr−1 (4%-23% of the intensity of the isotropic diffuse component measured with the LAT).We anticipate that∼10 galaxies could be detected by their cosmic-ray-induced gamma-ray emission during a 10 year Fermi mission.

The VIMOS VLT Deep Survey final data release: a spectroscopic sample of 35 016 galaxies and AGN out to z ~ 6.7 selected with 17.5 ≤ iAB ≤ 24.75

Abstract: We describe the completed VIMOS VLT Deep Survey, and the final data release of 35016 galaxies and type-I AGN with measured spectroscopic redshifts up to redshift z~6.7, in areas 0.142 to 8.7 square degrees, and volumes from 0.5x10^6 to 2x10^7h^-3Mpc^3. We have selected samples of galaxies based solely on their i-band magnitude reaching i_{AB}=24.75. Spectra have been obtained with VIMOS on the ESO-VLT, integrating 0.75h, 4.5h and 18h for the Wide, Deep, and Ultra-Deep nested surveys. A total of 1263 galaxies have been re-observed independently within the VVDS, and from the VIPERS and MASSIV surveys. They are used to establish the redshift measurements reliability, to assess completeness, and to provide a weighting scheme taking into account the survey selection function. We describe the main properties of the VVDS samples, and the VVDS is compared to other spectroscopic surveys. In total we have obtained spectroscopic redshifts for 34594 galaxies, 422 type-I AGN, and 12430 Galactic stars. The survey has enabled to identify galaxies up to very high redshifts with 4669 redshifts in 1 3, and specific populations like LAE have been identified out to z=6.62. We show that the VVDS occupies a unique place in the parameter space defined by area, depth, redshift coverage, and number of spectra. The VVDS provides a comprehensive survey of the distant universe, covering all epochs since z, or more than 12 Gyr of cosmic time, with a uniform selection, the largest such sample to date. A wealth of science results derived from the VVDS have shed new light on the evolution of galaxies and AGN, and their distribution in space, over this large cosmic time. A final public release of the complete VVDS spectroscopic redshift sample is available at http://cesam.lam.fr/vvds.