Institution
Jagiellonian University
Education•Krakow, Poland•
About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.
Papers published on a yearly basis
Papers
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TL;DR: The correlation between RP-HPLC retention parameter log K (the logarithm of capacity factor K) and various calculated log P data is shown and the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well.
258 citations
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TL;DR: It is demonstrated that ADAM17 is needed for vital regenerative activities during the immune response by regulating the systemic availability of the proinflammatory cytokine TNF and in defective regeneration of epithelial cells and breakdown of the intestinal barrier.
Abstract: The protease a disintegrin and metalloprotease (ADAM) 17 cleaves tumor necrosis factor (TNF), L-selectin, and epidermal growth factor receptor (EGF-R) ligands from the plasma membrane. ADAM17 is expressed in most tissues and is up-regulated during inflammation and cancer. ADAM17-deficient mice are not viable. Conditional ADAM17 knockout models demonstrated proinflammatory activities of ADAM17 in septic shock via shedding of TNF. We used a novel gene targeting strategy to generate mice with dramatically reduced ADAM17 levels in all tissues. The resulting mice called ADAM17ex/ex were viable, showed compromised shedding of ADAM17 substrates from the cell surface, and developed eye, heart, and skin defects as a consequence of impaired EGF-R signaling caused by failure of shedding of EGF-R ligands. Unexpectedly, although the intestine of unchallenged homozygous ADAM17ex/ex mice was normal, ADAM17ex/ex mice showed substantially increased susceptibility to inflammation in dextran sulfate sodium colitis. This was a result of impaired shedding of EGF-R ligands resulting in failure to phosphorylate STAT3 via the EGF-R and, consequently, in defective regeneration of epithelial cells and breakdown of the intestinal barrier. Besides regulating the systemic availability of the proinflammatory cytokine TNF, our results demonstrate that ADAM17 is needed for vital regenerative activities during the immune response. Thus, our mouse model will help investigate ADAM17 as a potential drug target.
258 citations
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Max Planck Society1, Princeton University2, University of Hamburg3, University of Milan4, Virginia Tech5, University of Massachusetts Amherst6, Moscow State University7, University of Houston8, Petersburg Nuclear Physics Institute9, Kurchatov Institute10, Joint Institute for Nuclear Research11, PSL Research University12, Technische Universität München13, Jagiellonian University14, University of California, Los Angeles15
TL;DR: In this article, the Standard Solar Model (SMSM) was used for the first time and the results showed that SVM <7.7 10 8 cm 2 s 1 (95% C.L.
Abstract: 0.3) 10 8 cm 2 s 1 and <7.7 10 8 cm 2 s 1 (95% C.L.), respectively, in agreement with the Standard Solar Model. These results represent the rst mea
257 citations
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University of Valencia1, University of Vienna2, Autonomous University of Barcelona3, Roma Tre University4, University of Silesia in Katowice5, CERN6, Budker Institute of Nuclear Physics7, University of Bari8, SLAC National Accelerator Laboratory9, Goethe University Frankfurt10, Sofia University11, Uppsala University12, Sapienza University of Rome13, Kharkov Institute of Physics and Technology14, Humboldt University of Berlin15, Karlsruhe Institute of Technology16, National Autonomous University of Mexico17, King's College London18, University of Barcelona19, University of Calabria20, Jagiellonian University21, University of Mainz22, University of Bern23, Durham University24, University of Granada25, Princeton University26, Stanford University27
TL;DR: In this paper, the authors discuss the recent theoretical development and experimental progress in kaon physics relevant for the Standard Model tests in the flavor sector, the sensitivity we can reach in probing CPT and Quantum Mechanics from time evolution of entangled-kaon states, the interest for improving on the present measurements of non-leptonic and radiative decays of kaons and eta/eta' mesons, and contribution to understand the nature of light scalar mesons.
Abstract: Investigation at a f-factory can shed light on several debated issues in particle physics. We discuss: (i) recent theoretical development and experimental progress in kaon physics relevant for the Standard Model tests in the flavor sector, (ii) the sensitivity we can reach in probing CPT and Quantum Mechanics from time evolution of entangled-kaon states, (iii) the interest for improving on the present measurements of non-leptonic and radiative decays of kaons and eta/eta' mesons, (iv) the contribution to understand the nature of light scalar mesons, and (v) the opportunity to search for narrow di-lepton resonances suggested by recent models proposing a hidden dark-matter sector. We also report on the e(+)e(-) physics in the continuum with the measurements of (multi) hadronic cross sections and the study of gamma gamma processes.
257 citations
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TL;DR: Current knowledge on diatom photosynthetic pigments is summarized complemented by some new insights regarding their physico-chemical properties, biological role, and biosynthetic pathways, as well as the regulation of pigment level in the cell, methods of purification, and significance in industries.
Abstract: Photosynthetic pigments are bioactive compounds of great importance for the food, cosmetic, and pharmaceutical industries. They are not only responsible for capturing solar energy to carry out photosynthesis, but also play a role in photoprotective processes and display antioxidant activity, all of which contribute to effective biomass and oxygen production. Diatoms are organisms of a distinct pigment composition, substantially different from that present in plants. Apart from light-harvesting pigments such as chlorophyll a, chlorophyll c, and fucoxanthin, there is a group of photoprotective carotenoids which includes β-carotene and the xanthophylls, diatoxanthin, diadinoxanthin, violaxanthin, antheraxanthin, and zeaxanthin, which are engaged in the xanthophyll cycle. Additionally, some intermediate products of biosynthetic pathways have been identified in diatoms as well as unusual pigments, e.g., marennine. Marine algae have become widely recognized as a source of unique bioactive compounds for potential industrial, pharmaceutical, and medical applications. In this review, we summarize current knowledge on diatom photosynthetic pigments complemented by some new insights regarding their physico-chemical properties, biological role, and biosynthetic pathways, as well as the regulation of pigment level in the cell, methods of purification, and significance in industries.
256 citations
Authors
Showing all 17729 results
Name | H-index | Papers | Citations |
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Roxana Mehran | 141 | 1378 | 99398 |
Brad Abbott | 137 | 1566 | 98604 |
M. Morii | 134 | 1664 | 102074 |
M. Franklin | 134 | 1581 | 95304 |
John Huth | 131 | 1087 | 85341 |
Wladyslaw Dabrowski | 129 | 990 | 79728 |
Rostislav Konoplich | 128 | 811 | 73790 |
Michel Vetterli | 128 | 901 | 76064 |
Francois Corriveau | 128 | 1022 | 75729 |
Christoph Falk Anders | 126 | 734 | 68828 |
Tomasz Bulik | 121 | 698 | 86211 |
Elzbieta Richter-Was | 118 | 793 | 69127 |
S. H. Robertson | 116 | 1311 | 58582 |
S. J. Chen | 116 | 1559 | 62804 |
David M. Stern | 107 | 271 | 47461 |