Institution
Jagiellonian University
Education•Krakow, Poland•
About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.
Topics: Population, Catalysis, Large Hadron Collider, Galaxy, European union
Papers published on a yearly basis
Papers
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Smithsonian Tropical Research Institute1, James Cook University2, BirdLife International3, University of Zurich4, Massachusetts Institute of Technology5, University College London6, University of York7, University of Natural Resources and Life Sciences, Vienna8, University of Vienna9, Jagiellonian University10, University of Amsterdam11, University of Missouri12, Colgate University13, University of La Réunion14, The Wilderness Society15, National Autonomous University of Mexico16, Royal Botanic Gardens17, Columbus State University18, University of Koblenz and Landau19, Missouri Botanical Garden20, Makerere University21, University of Göttingen22, University of Costa Rica23, University of Florida24, Pontifical Xavierian University25, Universidad Veracruzana26, Natural History Museum27, Staatliches Museum für Naturkunde Stuttgart28, The Evergreen State College29, Colorado State University30, Field Museum of Natural History31, University of Leeds32, University of Puerto Rico33, Stellenbosch University34, Addis Ababa University35, University of California, Los Angeles36, Australian National University37
TL;DR: This paper found that species classified as elevational specialists (upper or lower-zone specialists) are relatively more frequent in the American than Asia-Pacific tropics, with African tropics being intermediate.
220 citations
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TL;DR: It is found that long-term exposure to airborne particulates leads to inflammation of the airways and activation of the cellular and humoral immune system.
Abstract: Human population data on air pollution and its effects on the immune system are scarce. A survey was conducted within the framework of the Central European Study of Air Quality and Respiratory Health (CESAR) to measure a panel of immune biomarkers in children of Bulgaria, Czech Republic, Hungary, Poland, Romania, and Slovakia. Seventeen cities were chosen to represent a wide range of exposure to outdoor air pollution. In each, ambient particulate matter of less than 10 microns diameter and less than 2.5 microns diameter (PM10 and PM2.5) were measured with a Harvard impactor. Blood was collected from 366 school children aged 9 to 11 yr between 11 April and 10 May 1996. The percentage of B, total T, CD4+, CD8+, and natural killer (NK) lymphocytes was determined by flow cytometry (Becton Dickinson); total immunoglobulins of class G, M, A and E (IgG, IgM, IgA, and IgE) were measured in serum using nephelometry (Behring). Associations between PM and each log-transformed biomarker concentration were studied by linear regression, in a two-stage model. The yearly average concentrations varied from 41 to 96 micrograms/m3 for PM10 across the 17 study areas, from 29 to 67 micrograms/m3 for PM2.5, and from 12 to 38 micrograms/m3 for PM10-2.5 (coarse). Number of B, CD4+, CD8+, and NK lymphocytes increased with increasing concentration of PM, having adjusted for age, gender, parental smoking, laboratory of analysis, and recent respiratory illness. Differences in lymphocyte number were larger and statistically significant for exposure to PM2.5. Similar results were found when we examined the association between PM and lymphocyte number separately for each laboratory. Total IgG was increased with increasing concentration of PM, significantly in the case of PM2.5. When we repeated the analyses with two other statistical approaches the results did not differ from those reported here. The effect of coarse PM on lymphocyte numbers appears small in comparison to PM2.5. One possible interpretation of our findings is that long-term exposure to airborne particulates leads to inflammation of the airways and activation of the cellular and humoral immune system.
220 citations
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TL;DR: In this paper, the authors reported the Fermi-LAT discovery of high energy (MeV/GeV) gamma-ray emission positionally consistent with the center of the radio galaxy M87, at a source significance of over 10 sigma in ten-months of all-sky survey data.
Abstract: We report the Fermi-LAT discovery of high-energy (MeV/GeV) gamma-ray emission positionally consistent with the center of the radio galaxy M87, at a source significance of over 10 sigma in ten-months of all-sky survey data. Following the detections of Cen A and Per A, this makes M87 the third radio galaxy seen with the LAT. The faint point-like gamma-ray source has a >100 MeV flux of 2.45 (+/- 0.63) x 10^-8 ph cm^-2 s^-1 (photon index = 2.26 +/- 0.13) with no significant variability detected within the LAT observation. This flux is comparable with the previous EGRET upper limit (< 2.18 x 10^-8 ph cm^-2 s^-1, 2 sigma), thus there is no evidence for a significant MeV/GeV flare on decade timescales. Contemporaneous Chandra and VLBA data indicate low activity in the unresolved X-ray and radio core relative to previous observations, suggesting M87 is in a quiescent overall level over the first year of Fermi-LAT observations. The LAT gamma-ray spectrum is modeled as synchrotron self-Compton (SSC) emission from the electron population producing the radio-to-X-ray emission in the core. The resultant SSC spectrum extrapolates smoothly from the LAT band to the historical-minimum TeV emission. Alternative models for the core and possible contributions from the kiloparsec-scale jet in M87 are considered, and can not be excluded.
220 citations
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TL;DR: The results showed that the highly metastatic MAT-LyLu cells responded to the application of the electric field strongly by migrating towards the cathode, which is consistent with functional voltage-gated Na+ channel expression occurring specifically inhighly metastatic cells.
Abstract: A two-part hypothesis has been tested, which proposes that (1) prostate
cancer cells are galvanotactic (i.e. respond to an electric field by moving
directionally) and (2) voltagegated Na+ channel activity, which was
shown previously to be expressed specifically by strongly metastatic cells,
controls galvanotaxis. Two well-defined rat (`Dunning9) cell lines, originally
derived from the same prostate tumour but differing markedly in their
metastatic ability, were used. Cells were exposed to exogenous direct-current
electric fields of physiological strength (0.1-4.0 V cm-1), their
reactions were recorded by light microscopy and analysed by a quantitative
tracking method. Voltage-gated Na+ channel activity was modulated
pharmacologically using a range of concentrations of a specific channel
blocker (tetrodotoxin) or an opener (veratridine). The results showed that the
highly metastatic MAT-LyLu cells responded to the application of the electric
field strongly by migrating towards the cathode. By contrast, the weakly
metastatic At-2 cells gave no such response. Tetrodotoxin suppressed the
galvanotactic response of the MAT-LyLu cells whereas veratridine enhanced it.
Both compounds had little effect on the AT-2 cells. These results are
consistent with functional voltage-gated Na+ channel expression
occurring specifically in highly metastatic cells. This is also the first
demonstration of control of galvanotaxis, in any cell type, by voltage-gated
Na+ channel activity. The possible underlying mechanisms and the in
vivo relevance of these findings are discussed.
219 citations
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TL;DR: Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation.
Abstract: In the present study the effect of quercetin and its major metabolites quercetin-3-glucuronide (Q3G) and isorhamnetin on inflammatory gene expression was determined in murine RAW264.7 macrophages stimulated with lipopolysaccharide. Quercetin and isorhamnetin but not Q3G significantly decreased mRNA and protein levels of tumor necrosis factor alpha. Furthermore a significant decrease in mRNA levels of interleukin 1β, interleukin 6, macrophage inflammatory protein 1α and inducible nitric oxide synthase was evident in response to the quercetin treatment. However Q3G did not affect inflammatory gene expression. Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation. Furthermore, proinflammatory microRNA-155 was down-regulated by quercetin and isorhamnetin but not by Q3G. Finally, anti-inflammatory properties of quercetin were confirmed in vivo in mice fed quercetin-enriched diets (0.1 mg quercetin/g diet) over 6 weeks.
219 citations
Authors
Showing all 17729 results
Name | H-index | Papers | Citations |
---|---|---|---|
Roxana Mehran | 141 | 1378 | 99398 |
Brad Abbott | 137 | 1566 | 98604 |
M. Morii | 134 | 1664 | 102074 |
M. Franklin | 134 | 1581 | 95304 |
John Huth | 131 | 1087 | 85341 |
Wladyslaw Dabrowski | 129 | 990 | 79728 |
Rostislav Konoplich | 128 | 811 | 73790 |
Michel Vetterli | 128 | 901 | 76064 |
Francois Corriveau | 128 | 1022 | 75729 |
Christoph Falk Anders | 126 | 734 | 68828 |
Tomasz Bulik | 121 | 698 | 86211 |
Elzbieta Richter-Was | 118 | 793 | 69127 |
S. H. Robertson | 116 | 1311 | 58582 |
S. J. Chen | 116 | 1559 | 62804 |
David M. Stern | 107 | 271 | 47461 |