Institution
Jawaharlal Nehru Technological University, Kakinada
Education•Kākināda, India•
About: Jawaharlal Nehru Technological University, Kakinada is a education organization based out in Kākināda, India. It is known for research contribution in the topics: Electric power system & Computer science. The organization has 1289 authors who have published 1594 publications receiving 8377 citations. The organization is also known as: College of engineering vizagapatnam & JNTU Kakinada.
Papers published on a yearly basis
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TL;DR: Current review focus on the discoveries of dual targeting agents in cancer therapy using rational, computational, proteomic, bioinformatics and polypharmacological approach that enables the discovery and rational design of effective and safe multi-target anticancer agents.
149 citations
TL;DR: This review discussed the methodologies of preparation and characterization of ASDs with an emphasis on understanding and predicting stability, and rational selection of polymers, preparation techniques with its advantages and disadvantages and characterize of polymeric amorphous solid dispersions.
138 citations
TL;DR: In this paper, a comparative performance of combined sulfate radical based EAOP+EC and EC+EAOP processes for the treatment of real field dyeing wastewater was presented, where Pt/Ti plate is used as anode and iron plate was used as cathode.
135 citations
TL;DR: In this article, a multilayer perceptron model was used with back-propagation algorithm using the input parameters of nose radius, cutting speed, feed and volume of material removed.
120 citations
TL;DR: LA induced cancer cell apoptosis by enhancing cellular oxidant status and inducing mitochondrial dysfunction, and n-6 PUFA linoleic acid inhibited tumor cell growth at high concentrations; while low concentrations (100-200 μM) promoted proliferation.
Abstract: Some polyunsaturated fatty acids (PUFAs), if not all, have been shown to have tumoricidal action, but their exact mechanism(s) of action is not clear. In the present study, we observed that n-6 PUFA linoleic acid (LA) inhibited tumor cell growth at high concentrations (above 300 μM); while low concentrations (100-200 μM) promoted proliferation. Analysis of cell mitochondrial membrane potential, reactive oxygen species (ROS) formation, malondialdehyde (MDA) accumulation and superoxide dismutase (SOD) activity suggested that anti-cancer action of LA is due to enhanced ROS generation and decreased cell anti-oxidant capacity that resulted in mitochondrial damage. Of the three cell lines tested, semi-differentiated colorectal cancer cells RKO were most sensitive to the cytotoxic action of LA, followed by undifferentiated colorectal cancer cell line (LOVO) while the normal human umbilical vein endothelial cells (HUVEC) were the most resistant (the degree of sensitivity to LA is as follows: RKO > LOVO > HUVEC). LA induced cell death was primed by mitochondrial apoptotic pathway. Pre-incubation of cancer cells with 100 μM LA for 24 hr enhanced sensitivity of differentiated and semi-differentiated cells to the subsequent exposure to LA. The relative resistance of LOVO cells to the cytotoxic action of LA is due to a reduction in the activation of caspase-3. Thus, LA induced cancer cell apoptosis by enhancing cellular oxidant status and inducing mitochondrial dysfunction.
110 citations
Authors
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| Name | H-index | Papers | Citations |
|---|---|---|---|
| Undurti N. Das | 46 | 210 | 8527 |
| Reddymasu Sreenivasulu | 20 | 58 | 925 |
| Sirigiri Sivanagaraju | 19 | 65 | 864 |
| Allam Appa Rao | 16 | 92 | 949 |
| A. Gopala Krishna | 15 | 52 | 560 |
| D. M. Potukuchi | 14 | 55 | 629 |
| S. Srinivas Kumar | 14 | 57 | 702 |
| Vps Naidu | 13 | 82 | 1051 |
| K. Satya Prasad | 13 | 93 | 525 |
| Siva Ganesh Malla | 11 | 21 | 616 |
| S. K. Patri | 10 | 32 | 240 |
| K. Srinivas | 10 | 34 | 305 |
| G. J. Naga Raju | 10 | 32 | 412 |
| Sai Kiran S.S. Pindiprolu | 9 | 24 | 264 |
| D.M. Potukuchi | 9 | 21 | 203 |