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Institution

Jawaharlal Nehru University

EducationNew Delhi, India
About: Jawaharlal Nehru University is a education organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Candida albicans. The organization has 6082 authors who have published 13455 publications receiving 245407 citations. The organization is also known as: JNU.


Papers
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Journal ArticleDOI
12 Apr 2011-PLOS ONE
TL;DR: The transcriptome and lipidome data provide the first novel insight into the intricate relationship between cellular iron, calcineurin signaling, membrane lipid homeostasis and drug susceptibility of Candida cells.
Abstract: We previously demonstrated that iron deprivation enhances drug susceptibility of Candida albicans by increasing membrane fluidity which correlated with the lower expression of ERG11 transcript and ergosterol levels. The iron restriction dependent membrane perturbations led to an increase in passive diffusion and drug susceptibility. The mechanisms underlying iron homeostasis and multidrug resistance (MDR), however, are not yet resolved. To evaluate the potential mechanisms, we used whole genome transcriptome and electrospray ionization tandem mass spectrometry (ESI-MS/MS) based lipidome analyses of iron deprived Candida cells to examine the new cellular circuitry of the MDR of this pathogen. Our transcriptome data revealed a link between calcineurin signaling and iron homeostasis. Among the several categories of iron deprivation responsive genes, the down regulation of calcineurin signaling genes including HSP90, CMP1 and CRZ1 was noteworthy. Interestingly, iron deprived Candida cells as well as iron acquisition defective mutants phenocopied molecular chaperone HSP90 and calcineurin mutants and thus were sensitive to alkaline pH, salinity and membrane perturbations. In contrast, sensitivity to above stresses did not change in iron deprived DSY2146 strain with a hyperactive allele of calcineurin. Although, iron deprivation phenocopied compromised HSP90 and calcineurin, it was independent of protein kinase C signaling cascade. Notably, the phenotypes associated with iron deprivation in genetically impaired calcineurin and HSP90 could be reversed with iron supplementation. The observed down regulation of ergosterol (ERG1, ERG2, ERG11 and ERG25) and sphingolipid biosynthesis (AUR1 and SCS7) genes followed by lipidome analysis confirmed that iron deprivation not only disrupted ergosterol biosynthesis, but it also affected sphingolipid homeostasis in Candida cells. These lipid compositional changes suggested extensive remodeling of the membranes in iron deprived Candida cells. Taken together, our data provide the first novel insight into the intricate relationship between cellular iron, calcineurin signaling, membrane lipid homeostasis and drug susceptibility of Candida cells.

62 citations

Journal ArticleDOI
TL;DR: A comparative analysis of the gender differences in time spent on unpaid work before and during the lockdown, and the reasons for the same are analyzed.
Abstract: The COVID-19 pandemic has exacerbated the already existing gender inequalities with substantial implications on women. With the closure of offices and educational institutions, and the emerging norm of work from home and online education, along with the lack of services of domestic worker, the need to perform unpaid chores in the household has increased. Simultaneously, the requirements of social distancing and sanitization have created new unpaid chores. Owing to the sexual division of labour, and gendered roles and social norms of performing domestic and care work, the burden of unpaid work falls disproportionately on women. In this context, the objective of the paper is to study the impact of COVID-19 on time spent on unpaid work and the underlying gender differences in the urban centres in India. Specifically, the paper will do a comparative analysis of the gender differences in time spent on unpaid work before and during the lockdown, and analyse the reasons for the same.

62 citations

Journal ArticleDOI
TL;DR: Rainy season crops are not likely to be as much nutrient stressed as winter season crops if leaf litter of these species is assumed to be the sole source of nutrients to crops in tree-crop mixed agroforestry.
Abstract: Chemical characteristics and decomposition patterns of six multipurpose tree species, viz., Alnus nepalensis, Albizzia lebbek, Boehmeria rugulosa, Dalbergia sissoo, Ficus glomerata and F. roxburghii were analysed in a mixed plantation established on an abandoned agricultural land site in a village at 1200 m altitude in Central Himalaya, India. Differences in chemical quality of litter species were most marked in polyphenol and N concentrations. A. lebbek, A. nepalensis and D. sissoo showed higher N (2.2–2.6%) but lower polyphenol concentrations (3.2–4.7%) than B. rugulosa, F. glomerata and F. roxburghii (0.96–1.97% N and 5.68–11.64% polyphenol). Significant effects of species, incubation time and species×incubation time interaction on monthly mass, N, P and K release rates were observed. A linear combination of rainfall and temperature explained the variation in monthly mass loss better than rainfall and temperature independently. Percentage mass remaining after 1 year of incubation varied from 30 to 50, N remaining from 40 to 86, P remaining from 33 to 56 and K remaining from 1 to 3. Annual decomposition constants of mass and N were positively correlated with C and N concentrations and negatively correlated with C/N, lignin/N, polyphenol/N and lignin+polyphenol/N ratios of fresh litter. As all the species studied showed the highest rates of N and P release during the rainy season, rainy season crops are not likely to be as much nutrient stressed as winter season crops if leaf litter of these species is assumed to be the sole source of nutrients to crops in tree-crop mixed agroforestry. A. lebbek, A. nepalensis, D. sissoo and F. glomerata seem to be more appropriate for rapid recovery in degraded lands as their litter decomposed faster than B. rugulosa and F. roxburghii. A diverse multipurpose tree community provides not only diverse products but may also render stable nutrient cycling.

62 citations

Journal ArticleDOI
TL;DR: In this paper, a dynamic theory of joint venture life cycle that relies on synergy, organisational learning and moral hazard is provided, and the authors demonstrate that depending on parameter values the outcome may involve any one of the following: stable joint venture formation, joint venture forming followed by breakdown, or Cournot competition in all the periods.

62 citations

Journal ArticleDOI
TL;DR: In this paper, the sources and fate of organic matter (OM) in the Pichavaram mangrove-estuarine ecosystem, Corg, Ntot, C/Natm, and stable isotopes (δ13Corg and δ15Norg) were investigated.

62 citations


Authors

Showing all 6255 results

NameH-indexPapersCitations
Ashok Kumar1515654164086
Rajesh Kumar1494439140830
Sanjay Gupta9990235039
Rakesh Kumar91195939017
Praveen Kumar88133935718
Rajendra Prasad8694529526
Mukesh K. Jain8553927485
Shiv Kumar Sarin8474028368
Gaurav Sharma82124431482
Santosh Kumar80119629391
Dinesh Mohan7928335775
Govindjee7642621800
Dipak K. Das7532717708
Amit Verma7049716162
Manoj Kumar6540816838
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202385
2022314
20211,314
20201,240
20191,066
20181,012