Jawaharlal Nehru University

About: Jawaharlal Nehru University is a education organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Politics. The organization has 6082 authors who have published 13455 publications receiving 245407 citations. The organization is also known as: JNU.

Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis

Abstract: We have shown previously that pure polyphenol curcumin I (CUR-I) shows antifungal activity against Candida species. By employing the chequerboard method, filter disc and time–kill assays, in the present study we demonstrate that CUR-I at non-antifungal concentration interacts synergistically with azoles and polyenes. For this, pure polyphenol CUR-I was tested for synergy with five azole and two polyene drugs – fluconazole (FLC), miconazole, ketoconazole (KTC), itraconazole (ITR), voriconazole (VRC), nystatin (NYS) and amphotericin B (AMB) – against 21 clinical isolates of Candida albicans with reduced antifungal sensitivity, as well as a drug-sensitive laboratory strain. Notably, there was a 10–35-fold drop in the MIC80 values of the drugs when CUR-I was used in combination with azoles and polyenes, with fractional inhibitory concentration index (FICI) values ranging between 0.09 and 0.5. Interestingly, the synergistic effect of CUR-I with FLC and AMB was associated with the accumulation of reactive oxygen species, which could be reversed by the addition of an antioxidant such as ascorbic acid. Furthermore, the combination of CUR-I and FLC/AMB triggered apoptosis that could also be reversed by ascorbic acid. We provide the first evidence that pure CUR-I in combination with azoles and polyenes represents a novel therapeutic strategy to improve the activity of common antifungals.

Future of wetlands in tropical and subtropical Asia, especially in the face of climate change

Abstract: Tropical and subtropical Asia differs from other tropical regions in its monsoonal climate and the dominant influence of the Hindukush and Himalayan mountain ranges which result in extremes of spatial and temporal variability in precipitation. However, several major rivers and their tributaries arise in the Himalayan ranges and are fed by thousands of glaciers. Huge sediment loads carried by these rivers result in important deltas at their mouths. The climatic and physiographic diversity have endowed the region with many kinds of wetlands. Of these, the peatswamps of southeast Asia constitute about 56% of the world’s tropical peatlands, and more than 42% of the world’s mangroves occur in South and southeast Asia. Among other wetlands, riverine swamps are rather restricted whereas the seasonal marshes are a dominant feature. Another characteristic feature of tropical Asia are the innumerable human-made and intensively managed wetlands of which the paddy fields and aquaculture ponds are the most extensive. Throughout tropical Asia, wetlands have been a part of the socio-cultural ethos of the people and many communities have lived in wetlands. However, the pressures of high population and the economic development have extensively impacted upon wetlands which have been transformed for paddy cultivation and aquaculture, drained and converted to other land uses for economic gains (e.g., conversion to oil palm), and degraded by discharge of domestic and industrial wastes. Invasive plant and animal species have also played a significant role. The climate change is already being felt in the rapid retreat of Himalayan glaciers, increased temperature and variability in precipitation as well as the frequency of extreme events. Sea level rise is seen as a major threat to the coastal wetlands, particularly the mangroves. Increasing droughts have caused frequent fires in Indonesian peat swamps that have further feedback impacts on regional climate. However, the actual threat to wetlands in this region arises from the extensive hydrological alterations being caused by storage, abstraction and diversion of river flows for agriculture, industry and hydropower. Currently, the state of our understanding wetlands in general, and the efforts and infrastructure for research and training in wetlands are very poor. Although a few wetlands have been designated as Ramsar sites, the policies aimed at wetland conservation are either non-existent or very weak. Human responses to greater uncertainty and variability in the available water resources in different parts of Asia will be crucial to the conservation of wetlands in the future.

Impact of land-use and land-cover change on groundwater quality in the Lower Shiwalik hills: a remote sensing and GIS based approach

Abstract: Human activities have exerted small to large scale changes on the hydrological cycle. The current scenario regarding groundwater resources suggests that globally there is a water crisis in terms of quantity (availability) and quality. Therefore there is a great need for the assessment and monitoring of quality and quantity of groundwater resources at local level. This paper presents a case study of the lower Shiwalik hills, in Rupnagar, Punjab, India, to trace land-use and land-cover changes during the past 17 years, with an emphasis on groundwater quality and quantity. This study was performed in alluvial and hilly terrain. The results show that the quantity of groundwater increased with the help of natural and artificial recharge due to change in land-use and land-cover pattern (increased area of fallow land). The quality of groundwater deteriorated due to input of fertilizers for enhancing the short-term soil fertility. Using a Remote Sensing and GIS based approach, we show the final results in map form. In particular we highlight a potential groundwater exploration site, which could be useful for district level planning. Our research shows that the change in land-use and land-cover affects the quantity and quality of groundwater.