Jaypee Institute of Information Technology

About: Jaypee Institute of Information Technology is a education organization based out in Noida, Uttar Pradesh, India. It is known for research contribution in the topics: Computer science & Cluster analysis. The organization has 2136 authors who have published 3435 publications receiving 31458 citations. The organization is also known as: JIIT Noida.

cKGSA Based Fuzzy Clustering Method for Image Segmentation of RGB-D Images

Abstract: With the introduction of low-cost depth image sensors, reliable image segmentation within RGB-D images is an ambitious goal of computer vision. However, in a cluttered scene, image segmentation has become a challenging problem. This paper presents a novel RGB-D image segmentation method, chaotic kbest gravitational search algorithm based fuzzy clustering (cKGSA-FC). First, the proposed method performs fuzzy clustering using cKGSA on different parameters and feature subsets to obtain multiple optimal clusters. Next, the proposed method combines the multiple clusters through the segmentation by aggregating superpixels (SAS) method on different combinations to generate the final segmentation result. The proposed method is evaluated on the standard RGB-D indoor image dataset namely; NYU depth v2 (NYUD2) and compared with the results obtained by performing fuzzy clustering through three existing clustering methods namely; gravitational search algorithm, fuzzy c-means, and kmeans. The evaluation of the results is done in terms of qualitative and quantitative. Experimental results confirm that the segmentation quality of the proposed method is superior than the compared methods.

The Wnt pathway: emerging anticancer strategies.

Abstract: The canonical Wnt cascade has emerged as a critical regulator of cancer cells. Activation of the Wnt signaling pathway has also been associated with stem cell, thus raising the possibility of its role in embryogenesis and in the proliferation of malignant cancer cells. Wnt pathway has been reported to be involved in normal physiological processes in adult animals and integrally associated with cancer cell growth and maintenance, thus has been harnessed to devise strategies for anticancer therapy. The presence or absence of some members in this pathway, such as β-catenin, Axin or APC, has been found to involve in different types of tumors in human beings. Dysregulation of the canonical Wnt/β-catenin signaling pathway, mostly by inactivating mutations of the APC tumor suppressor, or oncogenic mutations of β-catenin, has been implicated in colorectal tumorigenesis. Further, elevated levels of β-catenin protein, a hallmark of activated canonical Wnt pathway, have been significantly observed in common forms of human malignancies, indicating that activation of the Wnt pathway may play an important role in tumor development and hence could be a crucial consideration for drug development. The paper discusses the potential therapeutic and diagnostic strategies directing on Wnt pathways on the basis of recent patents and their analysis.

Oxidative Stress in Metabolic Disorders: Pathogenesis, Prevention, and Therapeutics

Abstract: Metabolic disorder is characterized by dyslipidemia, insulin refractoriness, defective insulin secretion, glucose intolerance, and chronic inflammation which contribute to dysfunctional cellular physiology and cellular redox imbalance. The increased oxidative environment contributes to a chronic inflammatory condition in the body and creates primary risk factor for the development of several diseases such as diabetes, arthritis, cancer, and cardiovascular complications. The increased oxidative stress in obesity and metabolic disorder can in turn cause progression and sustenance of inflammatory condition by upregulating redox signaling pathways and altered gene expression of inflammatory markers creating a vicious cycle.