Jaypee Institute of Information Technology

About: Jaypee Institute of Information Technology is a education organization based out in Noida, Uttar Pradesh, India. It is known for research contribution in the topics: Computer science & Cluster analysis. The organization has 2136 authors who have published 3435 publications receiving 31458 citations. The organization is also known as: JIIT Noida.

MicroRNA therapeutics: the emerging anticancer strategies.

Abstract: The genetic alterations and aberrant miRNA expression profiles have been identified as important events behind the emergence of cancer. This knowledge triggers the use of miRNA therapeutics as an anticancer strategy. Basically, MicroRNAs (miRNAs) are approximately 22-nucleotide long, endogenous non-protein-coding RNA molecules which function as important regulatory molecules that regulate gene and protein expression through the RNA interference (RNAi) machinery. Transcription of these molecules by RNA polymerases II and III, resulting in the generation of precursor microRNAs that undergo a series of cleavage events, consequently, generate the mature microRNA. The biogenesis pathway is mediated by the two important cleavage events such as nuclear and cytoplasmic. The regulatory functions of microRNAs are accomplished through the RNA-induced silencing complex (RISC), leading to translational repression and hence, regulate the gene expression. The current progress in the development of strategies for miRNA-based anticancer therapies is due to its involvement in cellular, developmental and biological processes including regulation in cancer cell and modulation by various cancer chemoprophylaxis agents. Although miRNA therapeutics have been found to suppress gene expression effectively as compared to anti-sense oligonucleotide strategies, but it is bound with some limitations viz. identification of tissue specific miRNA, biological instability, off-target effects and delivery in the cell system. Up to certain extent, these hurdles have been resolved by chemical modifications using cholesterol conjugation, morpholinos, cationic lipids and cationic nanoparticles. Still more research is needed to understand the mechanism of action for better miRNA therapeutics. The paper discusses the potential miRNA therapeutics and diagnostic applications for cancer prevention, based on recent patents and their analysis.

Nose to Brain Delivery of Midazolam Loaded PLGA Nanoparticles: In Vitro and In Vivo Investigations.

Abstract: Objectives: The present study is aimed to develop poly(D, L-lactide-co-glycolic acid) (PLGA) nanoparticles (NP) loaded with midazolam (Mdz) for nose to brain delivery Materials and Methods: NP were formulated by nanoprecipitation and characterized for z-average, zeta potential, % drug entrapment and ex vivo drug release Mdz NP (MNP) were radiolabeled with technetium-99m Biodistribution and gamma scintigraphic studies were performed on Sprague-Dawley rats following intranasal (in) and intravenous (iv) administration to trace the transport of Mdz for nose-to-brain delivery Results and Discussion: MNP showed z-average of 164±45nm with polydispersity index 0099±002 and zeta potential of -166±25mV Ex vivo drug studies indicated that MNP showed 29±12% of permeation upto 4h via sheep nasal mucosa, whereas Mdz suspension (MS) showed drug release of 83±12% within 4h Comparing in administration of MNP, MS and iv administration of MS, scintigraphy imaging and Brain/blood uptake ratios indicated higher brain targeting via in administration of MNP Conclusion: Results indicated that the in MNP could be employed as a non invasive mode of delivery system with improved drug entrapment, stability and controlled drug release over a period of time

Fabrication of efficient dye-sensitized solar cells with photoanode containing TiO2–Au and TiO2–Ag plasmonic nanocomposites

Abstract: Herein, we report the effect of incorporation of two types of plasmonic nanocomposites, TiO2–Au and TiO2–Ag in different ratios, in the TiO2 photoanode of dye-sensitized solar cells (DSSCs). Electrophoretic deposition technique (EPD) has been utilized for the deposition of these nanocomposite photoanodes. The high-resolution transmission electron microscopy reveals that the nanocomposites, TiO2–Au and TiO2–Ag, have a wide size distribution of Au (5–60 nm) and Ag (20–130 nm) nanoparticles embedded in the TiO2 matrix. The UV–Visible absorption spectra of these nanocomposite films reveal the enhancement in the optical density due to the plasmonic effect. The DSSC based on photoanode consists of plasmonic nanocomposite TiO2–Au:TiO2–Ag (3:1 ratio) showed power conversion efficiency (PCE) of 10.9% which is 187% higher than that pristine TiO2 counterpart. The enhancement in the PCE has been confirmed by the photoluminescence and electro-impedance spectroscopy indicating that both Au and Ag play an important role in enhancing the PCE of DSSCs due to the plasmonic effect.

Phase Evolution, Magnetic, Optical, and Dielectric Properties of Zr-Substituted Bi0.9Gd0.1FeO3 Multiferroics

Abstract: Polycrystalline BiFeO3 (BFO) and Bi0.90Gd0.10Fe1−xZrxO3 (x = 0.0–0.10; BGFZx) ceramics were synthesized by solid-state reaction method. Rietveld analysis of X-ray diffraction patterns showed that BFO and BGFZx = 0.0 samples are stabilized in rhombohedral structure (space group R3c), whereas a small fraction of orthorhombic phase (space group Pn21a) is observed for BGFZx = 0.03–0.10 samples. Suppression and disappearance of some Raman modes indicated a structural phase transition with addition of Zr dopant at Fe site. Magnetic measurements exhibited weak ferromagnetic behavior of BGFZx samples with increasing Zr+4 concentrations. The insertion of Gd+3 ions at Bi+3 sites and nonmagnetic Zr+4 ions at Fe+3 sites in Fe–O–Fe network suppressed the spin cycloid structure of BFO which in turn enhanced the magnetization of these ceramics. Electron spin resonance spectra revealed the breaking of spin cycloid of BFO due to the development of free spins with addition of Zr+4 dopants at Fe sites. UV–Visible diffuse reflectance spectra showed one d–d crystal field transition and two charge-transfer (C–T) transitions along with a sharp absorption of light in visible region for all samples. Almost frequency-independent dielectric constant and dielectric loss along with very low values of dielectric loss indicated greatly improved dielectric properties for BGFZx = 0.03–0.10 samples.