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Institution

Jaypee Institute of Information Technology

EducationNoida, Uttar Pradesh, India
About: Jaypee Institute of Information Technology is a education organization based out in Noida, Uttar Pradesh, India. It is known for research contribution in the topics: Cluster analysis & Wireless sensor network. The organization has 2136 authors who have published 3435 publications receiving 31458 citations. The organization is also known as: JIIT Noida.


Papers
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Journal ArticleDOI
TL;DR: Enterprise nanoemulsion is a potential approach for intranasal delivery of selegiline to decrease the damage due to free radicals, thus avoiding consequent biochemical alterations that arise during Parkinson's disease.
Abstract: Objective of this study was to determine whether the prepared nanoemulsion would be able to deliver selegiline to the brain by intranasal route, improving its bioavailability. Antioxidant activity, pharmacokinetic parameters, and dopamine concentration were determined. Oxidative stress models, which had Parkinson's disease-like symptoms, were used to evaluate the antioxidant activity of nanoemulsion loaded with selegiline in vivo. The antioxidant activity was evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and reducing power assay, which showed high scavenging efficiency for selegiline nanoemulsion compared to pure selegiline. Biochemical estimation results showed that the levels of antioxidant enzymes, including glutathione and superoxide dismutase, were increased, whereas the levels of thiobarbituric acid-reactive substances were decreased in intranasally administered selegiline nanoemulsion-treated group when compared with haloperidol-induced Parkinson's disease group (control). Moreover, selegiline nanoemulsion was found to be successful in decreasing the dopamine loss, indicating that nanoemulsion is a potential approach for intranasal delivery of selegiline to decrease the damage due to free radicals, thus avoiding consequent biochemical alterations that arise during Parkinson's disease. Brain:blood ratio of 2.207 > 0.093 of selegiline-loaded nanoemulsion (intranasally administered) > selegiline solution (administered intravenously), respectively, at 0.5 hours showed direct nose-to-brain delivery of drug bypassing blood-brain barrier. Selegiline-loaded nanoemulsion administered intranasally showed significantly high dopamine concentration (16.61 ± 3.06 ng/mL) compared to haloperidol-treated rats (8.59 ± 1.00 ng/mL) (p < 0.05). In this way, intranasal delivery of selegiline nanoemulsion might play an important role in the better management of Parkinson's disease.

38 citations

Journal ArticleDOI
TL;DR: In this paper, the authors compared the nonclassical properties of photon added and subtracted squeezed coherent states with specific focus on the higher-order non-classicalities, such as higher order squeezing, higher order sub-Poissonian photon statistics, and higher order antibunching.

38 citations

Journal ArticleDOI
TL;DR: A global crowdfunding platform called BitFund is proposed based on the need to an effective crowdfunding platform for developing smart nation and the inherent features of blockchain technology, which yields better results as compared to other generic algorithms for crowdfunding.

38 citations

Journal ArticleDOI
TL;DR: In this article, the authors present a detailed review of the security-critical drone applications, and security-related challenges in drone communication such as DoS attacks, Man-in-the-middle attacks, De-Authentication attacks, and so on.
Abstract: Drone security is currently a major topic of discussion among researchers and industrialists. Although there are multiple applications of drones, if the security challenges are not anticipated and required architectural changes are not made, the upcoming drone applications will not be able to serve their actual purpose. Therefore, in this paper, we present a detailed review of the security-critical drone applications, and security-related challenges in drone communication such as DoS attacks, Man-in-the-middle attacks, De-Authentication attacks, and so on. Furthermore, as part of solution architectures, the use of Blockchain, Software Defined Networks (SDN), Machine Learning, and Fog/Edge computing are discussed as these are the most emerging technologies. Drones are highly resource-constrained devices and therefore it is not possible to deploy heavy security algorithms on board. Blockchain can be used to cryptographically store all the data that is sent to/from the drones, thereby saving it from tampering and eavesdropping. Various ML algorithms can be used to detect malicious drones in the network and to detect safe routes. Additionally, the SDN technology can be used to make the drone network reliable by allowing the controller to keep a close check on data traffic, and fog computing can be used to keep the computation capabilities closer to the drones without overloading them.

38 citations

Journal ArticleDOI
TL;DR: The developed nanoemulsion could be used as a potential carrier of memantine for a direct nose to brain delivery to bypass the blood-brain barrier for the treatment of Alzheimer disease.
Abstract: Aim: A nanoemulsion loaded with memantine for intranasal delivery to bypass the blood-brain barrier for the treatment of Alzheimer disease.Method: The nanoemulsion was prepared using homogenisation...

38 citations


Authors

Showing all 2176 results

NameH-indexPapersCitations
Sanjay Gupta9990235039
Mohsen Guizani79111031282
José M. Merigó5536110658
Ashish Goel502059941
Avinash C. Pandey453017576
Krishan Kumar352424059
Yogendra Kumar Gupta351834571
Nidhi Gupta352664786
Anirban Pathak332143508
Amanpreet Kaur323675713
Navneet Sharma312193069
Garima Sharma31973348
Manoj Kumar301082660
Rahul Sharma301893298
Ghanshyam Singh292632957
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202321
202258
2021401
2020395
2019464
2018366