Showing papers by "Jewish Hospital published in 1968"
TL;DR: The recommended schedule of treatment for ara-C based on data is, therefore, daily infusions of 100 or 50 mg./m.2 in one hour for approximately 3 to 6 weeks followed by maintenance therapy of once weekly subcutaneous injection of 30 mg./ m.2 of aRA-C.
551 citations
TL;DR: The effect of compounds that uncouple oxidative phosphorylation on membrane function in Streptoccocus faecalis, an organism which relies upon glycolysis for the generation of metabolic energy, is studied and it appears that a proton-impermeable membrane is required for transport.
Abstract: We studied the effect of compounds that uncouple oxidative phosphorylation on membrane function in Streptoccocus faecalis, an organism which relies upon glycolysis for the generation of metabolic energy. At low concentrations (ranging from 10−7 to 10−4m), tetrachlorosalicylanilide, tetramethyldipicrylamine, carbonylcyanide m-chlorophenylhydrazone, pentachlorophenol, and dicoumarol strongly inhibited energy-dependent transport of rubidium, phosphate, and certain amino acids. However, these compounds had little effect on the generation of adenosine triphosphate via glycolysis or on its utilization for the synthesis of macromolecules. They also did not seriously inhibit uptake of those monosaccharides and amino acids which do not require concurrent metabolism. It is proposed that the uncouplers interfere with the utilization of metabolic energy for membrane transport. The uncouplers accelerated the translocation of protons across the cytoplasmic membrane. It appears that a proton-impermeable membrane is required for transport, perhaps, because a proton gradient is involved in the coupling of metabolic energy to the translocation of substrates across the membrane.
136 citations
TL;DR: There appears to be no race predilection for calcification, a slight sex predilections for females, and an age incidence that seems to support both the developmental and degenerative theories of etiology of calcification in the stylohyoid ligament.
91 citations
TL;DR: At a concentration of 10(-6)m, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+).
Abstract: At a concentration of 10(-6)m, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+). In the presence of certain antibiotics, the cells exhibited increased permeability to certain cations; internal Rb(+) was rapidly lost by exchange with external H(+), K(+) Rb(+), and, more slowly, with Na(+) and Li(+). No effect was observed on the penetration of other small molecules. Cation exchanges induced by nigericin and monactin were metabolically passive and apparently did not involve the energy-dependent K(+) pump. When the cells were washed, the cytoplasmic membrane recovered its original impermeability to cations. By use of monactin, we prepared cells whose K(+) content had been completely replaced by other cations, and the metabolic characteristics of K(+)-depleted cells were studied. Cells containing only Na(+) glycolyzed almost as well as did normal ones and, under proper conditions, could accumulate amino acids and orthophosphate. These cells also incorporated (14)C-uracil into ribonucleic acid but incorporation of (14)C-leucine into protein was strictly dependent upon the addition of K(+). When K(+) or Rb(+) was added to sodium-loaded cells undergoing glycolysis, these ions were accumulated by stoichiometric exchange for Na(+). From concurrent measurements of the rate of glycolysis, it was calculated that one mole-pair of cations was exchanged for each mole of adenosine triphosphate produced.
77 citations
TL;DR: This work has shown that during extracellular fluid volume expansion, a factor or factors other than changes in glomerular nitration rate and mineralocorticoid hormone activity influence sodium diuresis.
Abstract: A NEW concept of regulation of sodium excretion by the mammalian kidney has evolved since the work of DeWardener et al.1,2. During extracellular fluid volume expansion, a factor or factors other than changes in glomerular nitration rate and mineralocorticoid hormone activity influence sodium diuresis. The same factor(s) appear to contribute to the natriuresis per nephron initiated by nephron reduction and observed in advancing renal disease3. In both extracellular fluid volume expansion and nephron reduction there is evidence4,5 that a humoral substance inhibits sodium reabsorption in single proximal tubules of rats. At least a part of the natriuretic activity may be humorally mediated4 and Rector et al.5,6 have termed the active agent the “natriuretic hormone”. The agent has also been called the “third factor” (glomerular filtration rate representing the first factor and mineralocorticoid hormone activity the second factor).
74 citations
TL;DR: Characteristic features of the entire group, exclusive of Type IId included a posteriorly oriented loop directed toward the “Z” axis and relatively narrow loops especially in the frontal and right sagittal plane, which appear characteristic for the group of patients with PMD.
50 citations
TL;DR: There was a wide variation among the inhibitory activities; the lecithin analogs as a group were the most active and the two most effective inhibitors found were 3,4-dioctadecoxybutylphos-phonylcholine and 2-hexadecooxy-3-octadecoXYpropylphosphonylch Caroline.
47 citations
TL;DR: In stress disorders in general and infertility it is the interaction between man and his fellow-beings which produces illness; in infertility the quality of the relationship to the spouse, as well as to the rest of the family, which is of great importance.
46 citations
TL;DR: It is demonstrated for the first time that systemic hypercoagulability is not related to the absolute quantity of a circulating clotting factor, but rather to whether it is circulating in an activated form.
41 citations
TL;DR: In a group of inpatients with asthma of known and of unknown origin, the sensitivity to inhaled methacholine one day following the injection of influenza vaccine was not universally increased, but was found in only 11 of 24 individuals.
30 citations
TL;DR: Cerebrospinal fluid pressure and consequently perilymphatic fluid pressure was increased 5, 10, and 15 cm Hg above normal in 13 cats and with increasing pressure the CM pseudo-threshold showed a progr...
Abstract: Cerebrospinal fluid pressure and consequently perilymphatic fluid pressure was increased 5, 10, and 15 cm Hg above normal in 13 cats. With increasing pressure the CM pseudo-threshold showed a progr...
TL;DR: In vivo specific and pseudo-immune reactions between humoral constituents and the capsular substance were observed, and whether the humoral anticryptococcal polysaccharide was reactive in vivo for cryptococcal capsules after an experimental infection was sought.
Abstract: A nonprotective hyperimmune state characterized by high serum titers specific for cryptococcal capsular substance can be stimulated in mice by injections of soluble cryptococcal polysaccharide coupled to bovine gamma globulin. When the nonprotective quality of the antibody became apparent, we sought to learn whether the humoral anticryptococcal polysaccharide was reactive in vivo for cryptococcal capsules after an experimental infection. For this purpose homogenates of organs from infected mice were examined by immunofluorescence techniques for detecting mouse immunoglobulins on the capsules of tissue fungi. In vivo specific and pseudo-immune reactions between humoral constituents and the capsular substance were observed and differen-
TL;DR: It was found that abnormal electrocardiograms were present in 70% of the patients on admission and most likely represent myocardial damage.
Abstract: Electrocardiographic studies before and after treatment were performed in 30 children with lead poisoning. It was found that abnormal electrocardiograms were present in 70% of the patients on admission. After completion of therapy, the electrocardiographic findings remained abnormal in only four (13%) of the patients. The abnormalities described most likely represent myocardial damage. It is proposed that a cardiovascular evaluation should be made as a routine procedure in every child with lead poisoning.
TL;DR: The ability of concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.
Abstract: Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if concanavalin A was adsorbed with insoluble a2 - macroglobulin or if mice were first treated with nitrogen mustard. The ability of concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.
TL;DR: Most lung hernias in children are congenital and require no therapy, but large chest wall defects are approached directly and correction includes excision of the sac and reinforcement of the defect by periosteal and rib flaps from above and below.
TL;DR: The observation that hyperglycemia could be effected without reducing insulin level and that hyper glycemia can be evoked in pancreatectomized animal suggests an additional, noninsulinmediated, hyperglycemic mechanism.
Abstract: The propensity of diazoxide to induce hyperglycemia has been evident since Dollery and associates' initially recorded this, then undesirable, side-effect. Although administration of diazoxide reduces or blocks the insulin response to glucose in a wide range of hypoglycemic states, the observation that hyperglycemia could be effected without reducing insulin level^,^,^ and that hyperglycemia can be evoked in pancreatectomized animal^,^ suggests an additional, noninsulinmediated, hyperglycemic mechanism. The studies reported here were directed toward the demonstration and better definition of such an effect of diazoxide.
TL;DR: The results of these comparisons indicate that the use of canine factor VII deficient substrate plasma provides a reliable method for assaying factor VII.
TL;DR: This case report concerns the fourth recorded instance of renal‐cell carcinoma occurring in two members of the same immediate family—a sister and brother in the geriatric age group.
Abstract: This case report concerns the fourth recorded instance of renal-cell carcinoma occurring in two members of the same immediate family—a sister and brother in the geriatric age group.
In the sister's case, nephrectomy was performed and the patient is alive and clinically well three years later even though operation revealed extensive involvement of the hilar structures of the kidney. The brother is being managed with chemotherapy and radiation because of widespread carcinoma.
TL;DR: 2-Hexadecoxy-3-octadecoXYpropylphosphonate inhibits the stimulatory action of liver supernatant fractions on palmitate or oleate incorporation into triglycerides by microsomal fractions, supporting the view that the stimulatories activity is due to a phosphatidate phosphatase present in the supernatants.
TL;DR: Test-retest measures of Bekesy amplitude were obtained from 10 normal-hearing adults on 8 different days to determine the extent of intrasubject variability among hearing adults.
Abstract: Test-retest measures of Bekesy amplitude were obtained from 10 normal-hearing adults on 8 different days. These measures were analyzed to determine: (1) the extent of intrasubject variability among...
TL;DR: A major characteristic of phantoms of the genitalia, in contrast to those of skeletal parts, appears to be their marked relationship to chronological age.
TL;DR: "The underlying dynamics should be understood by the clinician who treats the adolescent," says the report.
Abstract: \"The underlying dynamics should be understood by the clinician who treats the adolescent.\
TL;DR: A patient with panhypopituitarism suffered from an adrenal crisis after an uncomplicated dental extraction because the seriousness of her systemic condition and the need for constant medication and periodic check-ups was never fully explained to her.
Abstract: A patient with panhypopituitarism suffered from an adrenal crisis after an uncomplicated dental extraction. The patient had discontinued her prescribed medication because the seriousness of her systemic condition and the need for constant medication and periodic check-ups was never fully explained to her. A proper medical history obtained during the dental examination could have helped prevent this almost fatal crisis.
TL;DR: Application of these methods to the study of the connective tissue requirements for glucose and other simple metabolites is presented and Tyrosine was found to be rapidly incorporated into 1 M NaCl-soluble, collagenase-resistant proteins.
TL;DR: Of six antibiotics investigated, streptovaricin C had the most marked chemotherapeutic effect on Mycobacterium kansasii infections in mice, and by the intraperitoneal route this antibiotic caused elimination of the pathogens from all organs.
Abstract: Of six antibiotics investigated, streptovaricin C had the most marked chemotherapeutic effect on Mycobacterium kansasii infections in mice. By the intraperitoneal route this antibiotic caused elimination of the pathogens from all organs. Kanamycin eliminated the pathogens from the lungs of all animals and from the spleens and livers of most of them. Bluensomycin also removed the pathogens from the lungs of all animals, and spectinomycin and lincomycin, from the lungs of the majority of the animals. The three latter antibiotics lowered the bacterial counts in liver and spleen. Streptovaricin C also decreased the bacterial counts in brain, spleen, and liver of mice inoculated intracerebrally with M. kansasii. In one experiment it completely eliminated this pathogen from the spleen and almost completely from the liver. The effect of streptovaricin C on the cerebral infection was more marked than that of streptovaricin complex. Respiratory and cerebral infections of mice with M. avium, serotypes I and II, were limited by streptovaricin C, and marked decreases of the bacterial counts in brain, lungs, spleen, and liver were observed.
TL;DR: In the course of performing routine Papanicolaou smears in a voluntary hospital, 67 abnormal smears were obtained from 21,244 delivered patients, and patients with carcinoma in situ, cervicitis, and invasive squamous carcinoma were diagnosed.