Showing papers by "Jewish Hospital published in 1981"
TL;DR: This review focuses on the clinical implications of normal, abnormal, and compensatory lung growth and development from a morphologic, physiologic, and biochemical point of view.
166 citations
TL;DR: The overall success of treatment in the 122 patients was 61%.
Abstract: During eleven and one-half years, 122 patients with M. intracellulare disease were treated at National Jewish Hospital and Research Center, Denver, Colorado. Of the 81 patients treated with multiple drug chemotherapy, 63 (78%) were considered to be treatment successes. On follow-up (averaging 55 months) 40 of the 63 patients had remained clinically stable or improved and 12 had grown worse. Ten of these 63 patients had relapsed. Of the 63 patients considered to be treatment successes, 23 (36.5%) had died during follow-up, mostly of pulmonary disease. Of the 18 patients who failed to respond to chemotherapy, 2 were later successfully treated with surgery, 5 patients were clinically worsening, and 8 (44%) had died during a follow-up period averaging 43 months. A group of 41 patients had indeterminate results with chemotherapy. Eight had died while in the hospital. Follow-up information after an average of 43 months indicated that 9 patients became treatment successes (5 with chemotherapy, 4 with surgery), 12 were clinically stable or improving, and an additional 13 had died for a total of 21 deaths (51%). The overall success of treatment in the 122 patients was 61%. Fifty-two (43%) died during the study. Many patients will respond to drug therapy and remain clinically well for years. Because of the potential seriousness of this disease in some patients, multiple drug chemotherapy should be used.
116 citations
TL;DR: The presence, ultrastructurally, of well‐developed basement membrane, myogenic type filaments, and pinocytotic vesicles in a tumor with light microscopic features suggestive of hemangiopericytoma would consolidate the diagnosis and usually eliminate diagnostic uncertainty.
Abstract: An ultrastructural study of three cases of hemangiopericytoma showed cells partially or completely enveloped by well-formed basement membrane and basement membrane-like material. The cells exhibited prominent cytoplasmic filaments, some showing dense body formation, interdigitating cytoplasmic processes, and pinocytotic vesicles. A review of the literature revealed only 19 other cases of hemangiopericytoma studied by electron microscopy, and these included seven cases of meningeal origin (“angioblastic meningioma”). The most consistent feature seen in all but two cases was the presence of a basal lamina or basal lamina-like material either partially or completely surrounding tumor cells and separating endothelial cells from pericytes. The light microscopic diagnosis of hemangiopericytoma is difficult, and there is a tendency to append the diagnosis to a variety of other tumors with a prominent vascular pattern in which other specific diagnoses are not immediately evident. The presence, ultrastructurally, of well-developed basement membrane, myogenic type filaments, and pinocytotic vesicles in a tumor with light microscopic features suggestive of hemangiopericytoma would consolidate the diagnosis and usually eliminate diagnostic uncertainty. Cancer 47:906–914, 1981.
101 citations
TL;DR: Examination of assay results revealed that the presence of unextracted plasma enhanced the binding of labeled ligands to antisera (%Bo) but thereafter, the displacement of ligand by increasing quantities of the reference prostaglandin paralleled the results in buffer throughout the range of the assay.
98 citations
TL;DR: Mice sensitized with various protein antigens emulsified in complete Freund's adjuvant by a subcutaneous injection at the base of the tail exhibited both immediate and delayed type hypersensitivities 7-8 days following sensitization.
90 citations
TL;DR: The notion that the disruption of an attachment bond produced by peer separation may impair these measurements of cellular immune function, and may be related to the increase in morbidity and mortality seen after bereavement, is supported.
85 citations
TL;DR: Findings are consistent with theories and behavioral data suggesting differences between males and females in the development of language and spatial functions.
77 citations
TL;DR: Analysis of the unirradiated carcinomas showed no relationship between SPF and various clinical and morphologic features that included age, race, sex, site, size, Dukes' stage, histologic grade of the tumor, number of metastasis‐bearing regional lymph nodes, presence of adenomas of the large bowel, survival or relapse‐free survival of the patient, or SPF.
Abstract: The S-phase fractions (SPFs) of epithelial cells in 100 resected colorectal carcinomas were measured by in vitro exposure to tritiated thymidine and autoradiography. The frequency distribution of SPFs was gaussian with a median of 17.8 per hundred in 90 unirradiated carcinomas, whereas in ten carcinomas given radiation therapy preoperatively, it was positively skewed with a median of 6.9. Analysis of the unirradiated carcinomas showed no relationship between SPF and various clinical and morphologic features that included age, race, sex, site, size, Dukes' stage, histologic grade of the tumor, number of metastasis-bearing regional lymph nodes, presence of adenomas of the large bowel, survival or relapse-free survival of the patient, or SPF or adjacent normal colorectal crypts. The results show no evidence that colorectal carcinomas can be divided into kinetic subsets. The spatial orientation of labeled cells in autoradiographs indicated presence of a nonproliferative fraction of cells in many tumors that may modulate response to radiation therapy and chemotherapy.
75 citations
TL;DR: This study assesses the reliability of rating past psychiatric symptoms and lifetime diagnoses in a currently ill population using the SADS and RDC to demonstrate that it is possible for raters from different research centers to reliably rate lifetime diagnoses and previous symptoms.
71 citations
TL;DR: Biochemical study of fibroepithelial tumors of the female breast showed presence of progesterone receptor (PgR) in all five cystosarcoma phyllodes (two malignant, three benign), and in 11 of 13 fibroadenomas tested, suggesting that progestational therapy, and possibly other forms of hormonal therapy, should be tested in the treatment of advanced, malignant cysto-phyllodes.
Abstract: Biochemical study of fibroepithelial tumors of the female breast showed presence of progesterone receptor (PgR) in all five cystosarcoma phyllodes (two malignant, three benign), and in 11 of 13 fibroadenomas tested. Estrogen receptor (ER) was detected in only one of five cystosarcomas and 2 of 13 fibroadenomas. The relative volumes occupied by epithelium and stroma in each tumor were measured from histologic sections. The results were consistent with presence of PgR in the stroma and ER in the epithelium. Different types of cystosarcoma (benign and malignant) and different types of fibroadenomas (intracanalicular, pericanalicular, and mixed) did not differ significantly in content of PgR, and mean levels of PgR in cystosarcoma were comparable with those in fibroadenomas. The presence of PgR in cystosarcomas suggests that progestational therapy, and possibly other forms of hormonal therapy, should be tested in the treatment of advanced, malignant cystosarcoma phyllodes.
61 citations
TL;DR: It is concluded that a change in temperature has a direct influence on airway smooth muscle cells, affecting resting membrane potential, (Na+ + K+)-ATPase activity of airway Smooth Muscle cells, and the contractile response of these cells to histamine.
TL;DR: There is an exception to every rule; in this case the exception is Salmonella dublin, which in western Europe is a highly antibiotic-resistant serotype in cattle and appears in humans with a similar--and unusual--pattern of resistance.
Abstract: Nontyphoid salmonellosis has been said to be a zoonosis; hence, antibiotic resistance in the salmonella serotypes is thought to be derived directly from resistance in the animal reservoir. This thesis seems incorrect for the following reasons: (1) Typhoid and paratyphoidal salmonellae are clearly exceptions to the rule since they are restricted to human hosts. (2) Salmonella isolates involved in food-borne outbreaks disease have not been notable in terms of their antibiotic resistance. (3) In contrast, outbreaks of nosocomial disease, transmitted from person to person and persisting for long periods, have produced and disseminated multiple resistant salmonellae, such as Salmonella wien (another serotype without an animal reservoir) in western Europe. (4) In western Europe and the United States, there are often large differences between the resistance of isolates from animals and that of isolates from humans. (5) In most reported outbreaks of disease caused by antibiotic-resistant Salmonella in humans or animals, the administration of therapeutic concentrations of antibiotics has been implicated. (6) The role of low-concentration, growth-promoting antibiotic feed supplements has been much discussed but never has been delineated or proven. In fact, these supplements probably are totally irrelevant to the development of antibiotic resistance in Salmonella. With regard to Salmonella, there is an exception to every rule; in this case the exception is Salmonella dublin, which in western Europe is a highly antibiotic-resistant serotype in cattle and appears in humans with a similar--and unusual--pattern of resistance.
TL;DR: The Schaefer seroagglutination test is useful in epidemiologic studies of nontuberculous mycobacteria, especially the Mycobacterium avium-intracellulare-scrofulaceum complex.
Abstract: The Schaefer seroagglutination test is useful in epidemiologic studies of nontuberculous mycobacteria, especially the Mycobacterium avium-intracellulare-scrofulaceum complex Serovars 8, 16, 4, 19, 9, 42, and 1 were isolated most frequently from patients in the United States in the period 1976 to mid-1978 Several so-called double serovars were found serologically It appears that this is an artifact due to cross-reacting antigens, because only one antigen is seen using chromatographic analyses Further development of this system and its use in conjunction with other methods offer a valuable method for the study of nontuberculous mycobacteria
TL;DR: Fifteen asthmatic children who required daily theophylline therapy were studied for effect of erythromycin ethyl-succinate on theophyLLine clearance, and patients receiving therapeutic doses of theophylla are at considerable risk of the oxygen deprivation if EES is co-administered.
TL;DR: A large kindred in which IHP, presenting with hypocalcemia seizures in infant boys only, appears to be transmitted as an X-linked recessive trait is reported.
TL;DR: The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci.
Abstract: The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci. MK 0787 was the most active and moxalactam was the least active of these drugs, except against methicillin-resistant Staphylococcus aureus, where vancomycin was most active, and penicillin-resistant pneumococci, where cefotaxime was more active.
TL;DR: The protein resembles the GTP-binding regulatory factor of vertebrate adenylate cyclase and may play an analogous role in D. discoideum, which is found in the membranes of both vegetative and developing amoebae.
TL;DR: It is conducted that both acute sesitization and resentization on one hand and repeated exposure of sensitized aninals to inhaled albumin on the other will alter mechanism9s) responsible for the maintaenance of membrane potential and the regulation of excitation-contraction coupling in airway smooth muscle.
TL;DR: Purified human platelet derived growth factor stimulates the phosphorylation of an ⋍33,000 M. W.W. protein in Swiss mouse 3T3 cells, which can be detected 3 min after 32 P-labelled cells are stimulated by PDGF.
TL;DR: The phosphoproteins of Dictyostelium discoideum were compared at different stages of development of polyacrylamide gel electrophoresis and certain phosphoprotein of vegetative amoebae were conserved while others appeared and disappeared during development.
Abstract: The phosphoproteins of Dictyostelium discoideum were compared at different stages of development by polyacrylamide gel electrophoresis. Certain phosphoproteins of vegetative amoebae were conserved while others appeared and disappeared during development. Four major phosphoproteins with apparent subunit molecular weights of 50,000, 47,000, 38,000, and 34,000 disappeared precociously in response to exogenous cAMP. Two membranal phosphoproteins, with apparent subunit molecular weights of 80,000 and 81,000, appeared precociously in response to added cAMP. One of these phosphoproteins, molecular weight of 80,000, has been identified tentatively as the “contact site A” glycoprotein. Another membranal protein, with apparent subunit molecular weight of 42,000, unaffected in its appearance by cAMP, has been identified tentatively as phosphoactin.
TL;DR: Eight children from seven presumably unrelated families were identified independently as having an unbalanced recombinant chromosome resulting in the presence of extra material on the short arm of a chromosome 8, suggesting a common origin of the pericentric inversion.
Abstract: Eight children from seven presumably unrelated families were identified independently as having an unbalanced recombinant chromosome resulting in the presence of extra material on the short arm of a chromosome 8. Parental chromosomes were analyzed, and one member of each couple (four fathers and three mothers) was found to carry a pericentric inversion of a chromosome 8 [inv(8)(p23q22)]. The propositi had an unbalanced recombinant chromosome [rec(8),dup q,inv(8)(p23q22)]. The affected infants all had developmental delay, congenital heart disease, and unusual appearance. A common origin of the pericentric inversion was suggested because of geographic location and Mexican--American ancestry of the seven families.
TL;DR: The synthesis of the adenylate cyclase of Escherichia coli, appears to be regulated negatively by the cAMP receptor protein CRP, based on a comparison of adenYLate cycl enzyme activities measured in vitro with the rates of cAMP synthesis by intact bacteria.
Abstract: The synthesis of the adenylate cyclase [ATP pyrophosphatelyase-(cyclizing), E.C. 4.6.1.1.] of Escherichia coli, appears to be regulated negatively by the cAMP receptor protein CRP. This conclusion is based on a comparison of adenylate cyclase activities measured in vitro with the rates of cAMP synthesis by intact bacteria. The activity of adenylate cyclase, depending on conditions of growth, is also regulated by CRP; this effect, however, is indirect insofar as it is mediated by a protein or proteins under CRP control.
TL;DR: Thermoinducible mini-Mu prophage which have internal deletions spanning various portions of the αG regions were used to analyze the replication process of bacteriophage Mu, indicating that in the region between genes B and C a function(s) exists which amplifies the replication of Mu DNA.
TL;DR: The 65K preparation of LAM is an effective immunogen in generating an aggregation blocking xenoantiserum specific for embryonic chick liver cells, and the isolated LAM appears to be an intrinsic, trypsin-resistant, membrane glycoprotein of approximately 65,000 daltons.
TL;DR: A cAMP-binding protein isolated from the cytosol of Dictyostelium discoideum was partially purified; the protein binds cAMP maximally at pH 5–7 and its K D is in the nanomolar range and the specificity for cAMP is high.
TL;DR: Temporal-linked mastoids placements showed an effect opposite to that seen for the vertex-referenced leads with lower amplitude AEPs occurring from the hemisphere purported to be most activated by the task, replicating previous findings.
TL;DR: Treatment with allopurinol provided protection against the untoward pathophysiologic changes which attend this kind of experimental infarct and appears to alter adrenal steroidogenesis which may also play a role in the myocardial salutary effects of this drug.
TL;DR: Even though transillumination of the frontal paranasal sinus has some predictive value, it has limited usefulness as a diagnostic tool and is not an adequate substitute for roentgenogram.
Abstract: The reliability of transillumination versus roentgenogram to diagnose maxillary and frontal paranasal sinus disease was assessed in 52 subjects with rhinitis and/or asthma. Two different otolaryngologists transilluminated the sinuses while the roentgenograms were evaluated by a radiologist and a third otolaryngologist. Patients filled in questionnaires of symptoms. There was excellent agreement (p < 0.001) between otolaryngologists regarding transillumination of the frontal sinuses but not the maxillary sinuses. Similarly, transillumination of the frontal sinuses correlated well with the roentgenograms. This was not true for transillumination of the maxillary sinuses. Although pain in the upper teeth related well to the presence of frontal disease, sinus headache was a frequent complaint but not useful as a predictor of sinus disease. Even though transillumination of the frontal paranasal sinus has some predictive value, the technique of transillumination has limited usefulness as a diagnostic tool and is not an adequate substitute for roentgenogram.
TL;DR: An imbalance of arachidonic acid metabolism in platelets from asthmatic patients is indicated, indicating an imbalance in cyclooxygenase and lipoxygenases pathways.
TL;DR: Data from in vivo and in vitro studies suggest that PAF is intimately involved in multiple interactions between neurophils and platelets, as mediated by PAF released from neutrophils.
Abstract: The role of the platelet-neutrophil interaction in inflammation is discussed, as mediated by PAF released from neutrophils. Data fromin vivo andin vitro studies suggest that PAF is intimately involved in multiple interactions between neurophils and platelets.