Institution
Jewish Hospital
Healthcare•Cincinnati, Ohio, United States•
About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.
Topics: Antigen, Population, Pregnancy, Antibody, Transplantation
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This trial demonstrated for the first time a statistically significantly higher primary patency rate for a low-dose DCB versus PTA at 2 years, and indicated that a sustained treatment effect is achievable with aLow- dose DCB with an optimized coating formulation.
Abstract: Objectives The aim of this study was to assess the safety and effectiveness of a next-generation low-dose drug-coated balloon (DCB) designed to optimize the amount of drug transferred into the vessel wall and to maximize the amount of time the drug resides in the vessel wall. Background Several randomized controlled studies evaluating various DCBs have demonstrated a significantly higher patency rate compared with noncoated percutaneous transluminal angioplasty balloons at 1 year. However, the data are limited and vary by DCB at longer follow-up time points. An earlier generation low-dose DCB failed to demonstrate significant treatment effect at 2 years, raising questions regarding the durability of low-dose DCBs. Methods In this prospective, multicenter trial, 294 patients were randomized (3:1) to treatment with a DCB or an uncoated percutaneous transluminal angioplasty balloon. Assessments at 2 years included primary patency with duplex ultrasonography, clinically driven target lesion revascularization, and functional outcomes. Results Primary patency at 2 years was significantly higher in the DCB cohort (75.9% vs. 61.0%; p = 0.025), and the rate of clinically driven target lesion revascularization was significantly lower (12.1% vs. 30.5%; p Conclusions A sustained treatment effect is achievable with a low-dose DCB with an optimized coating formulation. This trial demonstrated for the first time a statistically significantly higher primary patency rate for a low-dose DCB versus PTA at 2 years. (CVI Drug Coated Balloon European Randomized Clinical Trial; NCT01858363)
50 citations
••
TL;DR: The hypothesis that alterations in the metabolism of endogenous DLC and in their interactions with the Na/K-ATPase may be associated with the development of malignancies is raised.
Abstract: The primary transport system of sodium and potassium across the plasma cell membrane, the Na/K-ATPase, is a vital enzyme involved in numerous cellular events. This enzyme is the receptor for plant and amphibian steroids such as ouabain, digoxin and bufalin. In the past decade several endogenous steroids, identical or similar to the plant and amphibian steroids, termed here collectively digitalis-like compounds (DLC), have been identified in human tissues. This paper raises the hypothesis that alterations in the metabolism of endogenous DLC and in their interactions with the Na/K-ATPase may be associated with the development of malignancies. This hypothesis is based on the review of the literature pointing to: 1. An abnormal activity of the Na/K-ATPase and its sensitivity to DLC in malignant cells; 2. Abnormal plasma DLC concentrations in cancer patients; 3. Abnormal synthesis and release of DLC in immune compromised mice; and 4. Beneficial effects of DLC in the treatment of cancer.
50 citations
••
TL;DR: The pattern of AERP amplitude asymmetry found for disabled readers, which was opposite to that found for normal readers, suggests that the same reading-related tasks activated different cerebral processes in the two groups studied.
50 citations
••
TL;DR: The work recorded here on the effect of isoniazid on macromolecule synthesis in this organism was prompted by the finding that isoniaZid is bactericidal only for actively growing cells5.
Abstract: THE physiological basis of the bactericidal action of isoniazid (isonicotinic acid hydrazide) on Mycobacterium tuberculosis is unknown, although several hypotheses have been proposed1–4. The work recorded here on the effect of isoniazid on macromolecule synthesis in this organism was prompted by the finding that isoniazid is bactericidal only for actively growing cells5.
50 citations
••
TL;DR: A review of the medical histories of 27 patients with kanamycin-resistant tubercle bacilli indicated that cross-resistance with capreomycin and viomycin occurs, but is unpredictable.
50 citations
Authors
Showing all 3894 results
Name | H-index | Papers | Citations |
---|---|---|---|
John C. Morris | 183 | 1441 | 168413 |
David L. Kaplan | 177 | 1944 | 146082 |
Robert H. Purcell | 139 | 666 | 70366 |
Nancy J. Cox | 135 | 778 | 109195 |
Jennifer S. Haas | 128 | 840 | 71315 |
David A. Cheresh | 125 | 337 | 62252 |
John W. Kappler | 122 | 464 | 57541 |
Philippa Marrack | 120 | 416 | 54345 |
Arthur Weiss | 117 | 380 | 45703 |
Thomas J. Kipps | 114 | 748 | 63240 |
Michael Pollak | 114 | 663 | 57793 |
Peter M. Henson | 112 | 369 | 54246 |
Roberto Bolli | 111 | 528 | 44010 |
William D. Foulkes | 108 | 682 | 45013 |
David A. Lynch | 108 | 714 | 59678 |