Jewish Hospital

About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.

Toward Early Diagnosis of Lung Cancer

Abstract: Our long term research goal is to develop a fully automated, image-based diagnostic system for early diagnosis of pulmonary nodules that may lead to lung cancer. In this paper, we focus on generating new probabilistic models for the estimated growth rate of the detected lung nodules from Low Dose Computed Tomography (LDCT). We propose a new methodology for 3D LDCT data registration which is non-rigid and involves two steps: (i) global target-to-prototype alignment of one scan to another using the learned prior appearance model followed by (ii) local alignment in order to correct for intricate relative deformations. Visual appearance of these chest images is described using a Markov---Gibbs random field (MGRF) model with multiple pairwise interaction. An affine transformation that globally registers a target to a prototype is estimated by the gradient ascent-based maximization of a special Gibbs energy function. To handle local deformations, we displace each voxel of the target over evolving closed equi-spaced surfaces (iso-surfaces) to closely match the prototype. The evolution of the iso-surfaces is guided by a speed function in the directions that minimize distances between the corresponding voxel pairs on the iso-surfaces in both the data sets. Preliminary results show that the proposed accurate registration could lead to precise diagnosis and identification of the development of the detected pulmonary nodules.

Applying the Stetler model of research utilization in staff development: revitalizing a preceptor program.

Abstract: Using a model for the utilization of research can aid and direct staff development educators in the appropriate application of existing research-based knowledge and help prevent the pitfalls of using research inaccurately. The Stetler Model of Research Utilization was applied to obtain support for and revitalize a preceptor program at one large metropolitan tertiary medical center. Applying the Stetler Model resulted in the improvement of nurses' satisfaction with their preceptors and a reduction in turnover rate.

Inorganic polyphosphate of high molecular weight from aerobacter aerogenes.

Abstract: is why both biotin and thiamine happened to be omitted here. Reversal of this growth inhibition did not occur when other pairs of B vitamins were similarly deleted. Further growth media were prepared substituting 0.1% Norit-treated, vitamin-free, casein hydrolysate (Nutritional Biochemicals Corp., Cleveland, Ohio) for glutamate, and this medium was supplemented by the addition of 0.01 ,Ag/ml of biotin. The media were sterilized by Millipore filtration after being adjusted to pH 6.8, and were held for 3 days before inoculation with 0.01 ml of a culture having an optical density of 0.1 at 420 m,u (Table 2). A marked growth reduction occurred in the presence of the B vitamins. These data show that casein hydrolysate is superior to glutamate as an amino acid source, but, in spite of the better

Glucose intolerance in the progeny of rats treated with single subdiabetogenic dose of alloxan.

Abstract: A single subdiabetogenic dose of alloxan administered to the weanling rat induces a persistent state of carbohydrate intolerance (latent diabetes) which does not progress to frank diabetes mellitus in such animals with either aging or multiple pregnancies. Alloxan-induced latent diabetes, in the rat, is transmissable to offspring either through the male or female parent with increasing glucose intolerance through the generations so far studied. This persistence of glucose intolerance in successive generations cannot be explained fully as yet, but may be attributed to alloxan-induced genetic changes. These changes are postulated to be persistent suppressive modifications of the action of genes concerned with glucose utilization. A significant sex difference in glucose disappearance occurs in the rat, given alloxan or not. This sex difference persists throughout succeeding generations until the latent diabetes becomes severe. Pregnancy increases the rate of glucose disappearance in the rat. Latent diabetic females of parent and F1 generations show a greater degree of increase than control animals.