Institution
Jewish Hospital
Healthcare•Cincinnati, Ohio, United States•
About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.
Topics: Antigen, Population, Pregnancy, Thrombophilia, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: Data suggest that leukotriene B4 is an important stimulus to neutrophil chemotaxis in inflammatory bowel disease and, thus, may play a major role in the amplification of the inflammatory response in this condition.
Abstract: An important histologic feature of inflammatory bowel disease (IBD) is infiltration of the colonic mucosa with neutrophils. To investigate the nature of the chemotactic agents responsible for this infiltration, colonic mucosa from three normals and nine patients with inflammatory bowel disease (seven ulcerative colitis, two Crohn's colitis) was assayed for chemotactic activity for human neutrophils in vitro in a Boyden chamber. There was more (greater than 10-fold more) chemotactic activity in homogenates of inflammatory bowel disease mucosa than in homogenates of normal colonic mucosa. Analysis of the chemotactic activity in the inflammatory bowel disease mucosa revealed that most was lipid extractable. Moreover, when the lipid extract was fractionated by reverse-phase high-pressure liquid chromatography, the only fraction with significant chemotactic activity was the fraction that coeluted with leukotriene B4. The chemotactic response to IBD mucosa was blocked by anti-LTB4 antisera. The amount of chemotactic activity in lipid extracts of different inflammatory bowel disease specimens correlated well with the concentration of leukotriene B4 measured by UV absorbance (250 ng/g of mucosa). These data suggest that leukotriene B4 is an important stimulus to neutrophil chemotaxis in inflammatory bowel disease and, thus, may play a major role in the amplification of the inflammatory response in this condition.
146 citations
TL;DR: A systematic literature review of S. pneumoniae resistance to beta-lactams, macrolides, lincosamides, fluoroquinolones, tetracyclines, and trimethoprim-sulfamethoxazole (TMP-SMX) finds effective treatment of resistant S pneumoniae is a growing concern.
Abstract: Background:Streptococcus pneumoniae is a major cause of pneumonia, meningitis, sepsis, bacteremia, and otitis media. S. pneumoniae has developed increased resistance to multiple classes of antibiotics.Study Design:Systematic literature review of prevalence, mechanisms, and clinical implications in S
146 citations
145 citations
TL;DR: Infection could not be detected with any greater certainty in patients who responded to the macrolide than in those who did not, with the use of such criteria as the results of culture of the sputum for bacteria and mycoplasma.
145 citations
TL;DR: It is concluded that adults with untreated XLH have osteomalacia that is frequently symptomatic and even greater morbidity is caused by degenerative joint disease arising from lower limb deformities.
144 citations
Authors
Showing all 3894 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John C. Morris | 183 | 1441 | 168413 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Robert H. Purcell | 139 | 666 | 70366 |
| Nancy J. Cox | 135 | 778 | 109195 |
| Jennifer S. Haas | 128 | 840 | 71315 |
| David A. Cheresh | 125 | 337 | 62252 |
| John W. Kappler | 122 | 464 | 57541 |
| Philippa Marrack | 120 | 416 | 54345 |
| Arthur Weiss | 117 | 380 | 45703 |
| Thomas J. Kipps | 114 | 748 | 63240 |
| Michael Pollak | 114 | 663 | 57793 |
| Peter M. Henson | 112 | 369 | 54246 |
| Roberto Bolli | 111 | 528 | 44010 |
| William D. Foulkes | 108 | 682 | 45013 |
| David A. Lynch | 108 | 714 | 59678 |