Jewish Hospital

About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.

Taking the "ouch" out of injections for children. Using distraction to decrease pain.

Abstract: Purpose:This research compared the effect of two forms of distraction on injection pain in a convenience sample of preschool children.Design:A quasi-experimental study of 105 children (53 girls and 52 boys) ages 4 to 6 years needing DPT immunizations. Data were collected at three sites: two

Gramicidin, Valinomycin, and Cation Permeability of Streptococcus faecalis

Abstract: Gramicidin and valinomycin in concentrations of 10−7 and 10−6m, respectively, inhibited the growth of Streptococcus faecalis. Inhibition of growth was associated with loss of Rb+ and K+ from the cells, and could be reversed by addition of excess K+. Cells treated with these antibiotics exhibited greatly increased permeability to certain cations; no effect was observed on the penetration of other small molecules. Unlike normal cells, cells treated with gramicidin rapidly lost internal Rb+ by passive exchange with external cations, including H+, all monovalent alkali metals, NH4+, Mg++, and tris(hydroxymethyl)aminomethane. Exchange was rapid even at 0 C and was independent of energy metabolism. The effect of valinomycin was more selective. Cellular Rb+ was rapidly displaced by external H+, K+, Rb+, and Cs+; other cations were less effective. The exchange was independent of metabolism but strongly affected by temperature. Under certain conditions, polyvalent cations inhibited exchange between 86Rb and Rb+ induced by valinomycin. The antibiotic apparently neither stimulates nor inhibits the energy-dependent K+ pump of S. faecalis, but exerts its effect on the passive permeability of the membrane to cations. The increased permeability to specific cations induced by gramicidin and valinomycin is a sufficient explanation for the inhibition of growth, glycolysis, and other processes.

Identifying vulnerable older adults with cancer: integrating geriatric assessment into oncology practice.

Abstract: OBJECTIVES: To integrate the principles of geriatric assessment into the care of older patients with cancer in order to identify vulnerable older adults and develop interventions to optimize cancer treatment. DESIGN: A brief, comprehensive, self-administered questionnaire and intervention algorithm were developed consisting of measures of geriatric assessment that are brief, reliable, validated, and predictive of mortality and morbidity in older patients. SETTING: Academic tertiary care cancer center and community-based satellite practice. PARTICIPANTS: Patients aged 65 and older with cancer. MEASUREMENTS: The questionnaire solicits information about the patient's functional status, comorbidity, psychological status, nutritional status, and social support. A scoring algorithm for referral to a multidisciplinary team was developed. RESULTS: Two hundred forty-five of 250 patients completed the questionnaire (mean age 76, range 65–95). The majority of patients were women (71%), white (95%), married (52%), and retired (90%), with a variety of tumor types and stages. Most patients (78%) completed the questionnaire on their own and reported acceptance of questionnaire length (91%), no difficult questions (94%), no upsetting questions (96%), and no missing questions (89%). The mean time to completion was 15 minutes, with a median of 12.5 (standard deviation 10, range 2–60). Information from this questionnaire helped identify physical and psychological impairments, poor nutrition, lack of social support, and untreated comorbidities. Appropriate referrals to a multidisciplinary team were made. CONCLUSION: This brief, comprehensive, self-administered questionnaire is feasible for use in the outpatient oncology setting and helped identify the needs of geriatric oncology patients. Prospective trials are needed to determine the effectiveness of the interventions offered.

A New Test (Blocking Test) for Rh Sensitization.

Abstract: As was first shown by Wiener and Peters,1 sensitization of Rh-negative individuals against the Rh factor can often be detected by in vitro tests for anti-Rh agglutinins in the individual’s plasma. However, it was soon found2,3 that there are many Rh-negative patients who are strongly sensitized to the Rh factor, as proved by the occurrence of an intragroup hemolytic transfusion reaction or a baby with erythroblastosis (hemolytic disease of the fetus and newborn), yet the plasma does not contain demonstrable anti-Rh agglutinins. The purpose of this paper is to describe a new in vitro test, the “blocking test,” with the aid of which Rh sensitization can be detected in many of these problem cases.