Institution
Jewish Hospital
Healthcare•Cincinnati, Ohio, United States•
About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.
Topics: Antigen, Population, Pregnancy, Thrombophilia, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: Clinicians treating patients similar to those in MESA, particularly older individuals and those with factors associated with more risk overestimation, may consider interpreting absolute ASCVD risk estimates with caution.
Abstract: Aims To evaluate the 2013 American Heart Association (AHA)-American College of Cardiology (ACC)-Atherosclerotic Cardiovascular Disease (ASCVD) risk score among four different race/ethnic groups and to ascertain which factors are most associated with risk overestimation by the AHA-ACC-ASCVD score.
Methods and results The Multi-Ethnic Study of Atherosclerosis (MESA), a prospective community-based cohort, was used to examine calibration and discrimination of the AHA-ACC-ASCVD risk score in 6441 White, Black, Chinese, and Hispanic Americans (aged 45–79 years and free of known ASCVD at baseline). Using univariable and multivariable absolute risk regression, we modelled the impact of individual risk factors on the discordance between observed and predicted 10-year ASCVD risk. Overestimation was observed in all race/ethnic groups in MESA and was highest among Chinese (252% for women and 314% for men) and lowest in White women (72%) and Hispanic men (67%). Higher age, Chinese race/ethnicity (when compared with White), systolic blood pressure (treated and untreated), diabetes, alcohol use, exercise, lipid-lowering medication, and aspirin use were all associated with more risk overestimation, whereas family history was associated with less risk overestimation in a multivariable model (all P < 0.05).
Conclusion The AHA-ACC-ASCVD risk score overestimates ASCVD risk among men, women, and all four race/ethnic groups evaluated in a modern American primary prevention cohort. Clinicians treating patients similar to those in MESA, particularly older individuals and those with factors associated with more risk overestimation, may consider interpreting absolute ASCVD risk estimates with caution.
129 citations
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TL;DR: A rigorous multistep approach with systematic literature reviews and 2 expert panels to develop QIs for SLE provides an opportunity to assess health care quality in patients with SLE and represents an initial step toward the important goal of improving care in this patient population.
Abstract: Objective
To systematically develop a quality indicator (QI) set for systemic lupus erythematosus (SLE)
Methods
We used a validated process that combined available scientific evidence and expert consensus to develop a QI set for SLE We extracted 20 candidate indicators from a systematic literature review of clinical practice guidelines pertaining to SLE An advisory panel revised and augmented these candidate indicators and, through 2 rounds of voting, arrived at 25 QIs These QIs advanced to the next phase of the project, in which we employed a modification of the RAND/UCLA Appropriateness Method A systematic review of the literature was performed for each QI, linking the proposed process of care to potential improved health outcomes After reviewing this scientific evidence, a second interdisciplinary expert panel convened to discuss the evidence and provide final ratings on the validity and feasibility of each QI
Results
The final expert panel rated 20 QIs as both valid and feasible Areas covered included diagnosis, general preventive strategies (eg, vaccinations, sun avoidance counseling, and screening for cardiovascular disease), osteoporosis prevention and treatment, drug toxicity monitoring, renal disease, and reproductive health
Conclusion
We employed a rigorous multistep approach with systematic literature reviews and 2 expert panels to develop QIs for SLE This new set of indicators provides an opportunity to assess health care quality in patients with SLE and represents an initial step toward the important goal of improving care in this patient population
127 citations
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TL;DR: It is revealed that mast cells can be degranulated by interaction with type 1 fimbriated E. coli and that FimH, the mannose-binding component of the fimbRIae, is a potent mast cell stimulant.
Abstract: The strategic location of mast cells at the host-environment interface and their ability to release potent mediators of inflammation have suggested that these cells may play a pivotal role in host defense against bacterial infection. The ability of the opportunistic pathogen, Escherichia coli, to induce degranulation of mast cells obtained from the mouse peritoneum was investigated. We determined that unlike a mutant derivative deficient in the FimH subunit of the fimbriae or nonfimbriated E. coli, type 1 fimbriated E. coli induced mast cell degranulation in vitro. The magnitude of mast cell degranulation was directly proportional to the number of adherent bacteria on the cell surface in the initial period of the interaction. Using a mouse model of bacterial peritonitis, we demonstrated mast cell degranulation and histamine release by type 1 fimbriated bacteria in vivo. Furthermore, beads coated with FimH but not with FimA, the major subunit of type 1 fimbriae, evoked mast cell release of histamine in vivo in amounts comparable to that elicited by type 1 fimbriated E. coli. These studies reveal that mast cells can be degranulated by interaction with type 1 fimbriated E. coli and that FimH, the mannose-binding component of the fimbriae, is a potent mast cell stimulant.
127 citations
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TL;DR: 28 children with chronic asthma completed a 12 wk double-blind trial of treatment with sodium cromoglycate (cromolyn sodium), theophylline, and a combination of both as part of a collaborative investigation of the relative efficacy of the two antiasthmatic agents.
127 citations
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TL;DR: This study indicates that fetal retina can be transplanted together with its RPE and survive for at least 6 months without evidence of rejection, however, no improvements in vision were observed, possibly due to the severe retinal degeneration of the patients.
126 citations
Authors
Showing all 3894 results
Name | H-index | Papers | Citations |
---|---|---|---|
John C. Morris | 183 | 1441 | 168413 |
David L. Kaplan | 177 | 1944 | 146082 |
Robert H. Purcell | 139 | 666 | 70366 |
Nancy J. Cox | 135 | 778 | 109195 |
Jennifer S. Haas | 128 | 840 | 71315 |
David A. Cheresh | 125 | 337 | 62252 |
John W. Kappler | 122 | 464 | 57541 |
Philippa Marrack | 120 | 416 | 54345 |
Arthur Weiss | 117 | 380 | 45703 |
Thomas J. Kipps | 114 | 748 | 63240 |
Michael Pollak | 114 | 663 | 57793 |
Peter M. Henson | 112 | 369 | 54246 |
Roberto Bolli | 111 | 528 | 44010 |
William D. Foulkes | 108 | 682 | 45013 |
David A. Lynch | 108 | 714 | 59678 |