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Showing papers by "Jodhpur National University published in 2010"


Journal ArticleDOI
TL;DR: A novel series of Schiff bases of benzothiazole derivatives were synthesized, screened for their antimicrobial activity and structures were elucidated on the basis of elemental analyses and spectral data.

93 citations


Journal ArticleDOI
TL;DR: This review will cover different types of polymers which can be used in formulation of colon targeted drug delivery systems.
Abstract: The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in formulation of colon targeted drug delivery systems.

52 citations


Posted Content
TL;DR: In this paper, the potential of transfersomal formulations for transdermal delivery of indinavir sulfate and to evaluate Span 80, Tween 80, Sodium cholate and Sodium deoxycholate as edge activators was investigated.
Abstract: The aim of the present study was to investigate the potential of transfersomal formulations for transdermal delivery of indinavir sulfate and to evaluate Span 80, Tween 80, Sodium cholate and Sodium deoxycholate as edge activators. Vesicles containing phosphatidylcholine (PC) mixed with edge activators and indinavir sulfate were prepared by conventional rotary evaporation method and characterized for various parameters including vesicles shape and surface morphology, size and size distribution, entrapment efficiency, elasticity, turbidity, and in vitro drug release. The compositions of refined formulations were predicted, liposomes prepared, and tested against control. Skin permeation profile of transfersomal formulation bearing indinavir sulfate was observed and the investigations revealed an enhanced transdermal flux (8.91±0.9 µg/cm2 /hr) and decrease lag time (0.9 hr) for indinavir sulfate. The obtained flux was nearly 7.5 and 12.04 times higher than conventional liposomal formulation bearing indinavir sulfate and plain drug solution. These results suggested that transfersomes are potential vehicles for improved transdermal delivery of indinavir sulfate and Span 80, Tween 80 and Sodium cholate were equivalent to Sodium deoxycholate as edge-activators.

16 citations


Journal ArticleDOI
TL;DR: Fenofibrate alone and in combination with telmisartan significantly ameliorated renal I/R injury and the additive beneficial effect of tel Misartan is predicted to reduce homocysteine-induced oxidative stress through reduced nitric oxide production during I-R.
Abstract: It was demonstrated that fenofibrate and telmisartan exerted renoprotective effects in ischemia/reperfusion (I/R) injury. Because the combination of fenofibrate and telmisartan synergistically enhanced peroxisome proliferator-activated receptor (PPAR) activation, we hypothesized that the combination of both drugs may exert prolonged beneficial effects in renal I/R injury than fenofibrate alone. Forty-eight male Wistar albino rats were divided into eight groups. Hyperlipidemia was induced by cholesterol feeding for 4 weeks. At the end of the fourth week, renal I/R injury was performed by occlusion of both renal vascular pedicles for 60 minutes, followed by 24 hours of reperfusion. In the treatment group, fenofibrate alone and in combination with telmisartan was administered 2 weeks prior to renal ischemia. At the end of the experiment, blood and kidneys were isolated for biochemical and histological analysis. I/R in hyperlipidemic rat shows significantly increased lipid peroxidation, nitric oxide, and myeloperoxidase activity, and depletion of antioxidant enzyme compared with control rats, and that was significantly restored after fenofibrate and telmisartan treatment. Also, significant increases in serum homocysteine level were detected following I/R. Fenofibrate treatment further elevated homocysteine level, which was reduced by telmisartan in combination with fenofibrate. The most significant histological damage was found in the hyperlipidemic rat subjected to renal I/R, which was reduced significantly with combination therapy. The results of this study concluded that fenofibrate alone and in combination with telmisartan significantly ameliorated renal I/R injury. The additive beneficial effect of telmisartan is predicted to reduce homocysteine-induced oxidative stress through reduced nitric oxide production during I/R.

16 citations


Journal ArticleDOI
TL;DR: This issue is written to attract all stakeholders to move toward the concept of harmonization, keeping in mind their need, challenges, and risks of not harmonizing the regulation as well.

13 citations


Journal ArticleDOI
TL;DR: The method was found to be precise, accurate, specific, and validated as per ICH guidelines and can be used for determination of Escitalopram Oxalate in tablet formulations.

12 citations


Posted Content
TL;DR: In this article, the authors designed and evaluated Sustained Release Mucoadhesive (SRM) microspheres of Metformin hydrochloride (MH) for effective control of diabetes type-2.
Abstract: The present work was envisaged to reduce the dosing frequency and improve patient compliance by designing and evaluating Sustained Release Mucoadhesive (SRM) microspheres of Metformin hydrochloride (MH) for effective control of diabetes type-2. Microspheres were prepared by emulsification solvent evaporation method using Sodium carboxy methyl cellulose (SCMC), Carbopol 934P (CP), and Hydroxyl propyl methyl cellulose K4M (HPMC) as a mucoadhesive polymers. Microspheres prepared were found discrete, spherical and free flowing. The microspheres exhibits good mucoadhesive properties and showed high drug entrapment efficiency. MH release from these microspheres was slow and extended and dependent on the type of polymer used. The mean particle size decreased and the drug release rate increased at higher Stirring speed of emulsion content. Among all the formulation, formulation F1 containing SCMC and F2 containing CP showed the best reproducible results and mucoadhesive profile with good surface morphology. The data obtained thus suggest that mucoadhesive microspheres can successfully design for sustained delivery of MH and to improve patient compliance.

9 citations


Journal ArticleDOI
TL;DR: This article is trying to explain GMDN as the prime method to reduce medical device errors, and to understand the concept of GMDN, to regulate the medical device throughout the globe.

8 citations


Journal ArticleDOI
TL;DR: International standards, such as, basic standards, group standards, and product standards, are a tool for harmonizing regulatory processes, to assure the safety, quality, and performance of medical devices.

2 citations


Journal ArticleDOI
TL;DR: A case of 45yr old female with a root coverage procedure has been reported and the esthetic demand together with reduction of root sensitivity and management of root caries or cervical abrasion are the main indication for root coverage.
Abstract: Gingival recession is defined as Displacement of soft tissue margin apical to the cemento-enamel junction. The esthetic demand together with reduction of root sensitivity and management of root caries or cervical abrasion are the main indication for root coverage. The root coverage procedure is quite predictable and also produces patient satisfaction. This paper reports a case of 45yr old female with a root coverage procedure has been discussed below.

2 citations


Journal ArticleDOI
TL;DR: Facial neuralgias are produced by a change in neurological structure or function and this type of neuropathic pain affects the mental health as well as quality of life of patients.
Abstract: Facial neuralgias are produced by a change in neurological structure or function. This type of neuropathic pain affects the mental health as well as quality of life of patients. There are different types of neuralgias affecting the oral and maxillofacial region. These unusual pains are linked to some possible mechanisms. Various diagnostic tests are done to diagnose the proper cause of facial neuralgia and according to it the medical and surgical treatment is done to provide relief to patient.

Journal ArticleDOI
TL;DR: A case of oral submucous fibrosis occurring in a 35 year old man is presented, which results in difficulty in laryngoscopy and intubations of the trachea.
Abstract: Oral submucous fibrosis (OSMF) is a pre-malignant lesion of the buccal mucosa caused by chewing betel quid. It results in the progressive inability to open the mouth. Patients with OSMF require anesthesia for trismus correction, resection and reconstructive surgery for coexisting oral malignancies or other unrelated surgeries. OSMF causes trismus, which results in difficulty in laryngoscopy and intubations of the trachea. A case of oral submucous fibrosis occurring in a 35 year old man is presented.

Journal ArticleDOI
TL;DR: Ehlers-Danlos syndrome, hypermobility type is generally considered the least severe type of EDS, although significant complications, primarily musculoskeletal, can and do occur.
Abstract: Ehlers-Danlos syndrome, hypermobility type is generally considered the least severe type of EDS, although significant complications, primarily musculoskeletal, can and do occur. The skin is often soft or velvety and may be mildly hyperextensible. Subluxations and dislocations are common; they may occur spontaneously or with minimal trauma and can be acutely painful. Degenerative joint disease is common. Chronic pain, distinct from that associated with acute dislocations or advanced osteoarthritis, is a serious complication of the condition and can be both physically and psychologically disabling. Easy bruising is common.

Journal ArticleDOI
TL;DR: Treatment of a 12 - year old male with generalized aggressive periodontitis consisted of thorough training in techniques of plaque control, scaling and root planning and administration of tetracycline 250 mg every six hours for three weeks, as well as combined surgery and antibiotic therapy.
Abstract: Aggressive periodontitis which is an uncommon condition is characterized by severe loss of attachment and destruction of alveolar bone around one or more permanent teeth during the period of pubescence. Aggressive periodontitis have localized and generalized forms. It is currently believed that combination of bacteriologic, immunologic and hereditary factors are of major importance in the etiology of this disease. The case was of a 12 - year old male and his clinical and radiographic findings were typical for generalized aggressive periodontitis. Treatment consisted of thorough training in techniques of plaque control, scaling and root planning and administration of tetracycline 250 mg every six hours for three weeks, as well as combined surgery and antibiotic therapy. But both failed to cure or control the disease mostly because of the non-cooperation with the oral hygiene instructions.