Showing papers by "Jodhpur National University published in 2018"

Comparative Study of the Efficacy of Newer Antioxitands Lycopene and Oxitard in the Treatment of Oral Submucous Fibrosis

Abstract: Objective: To compare the efficacy of oxitard and lycopene in the management of Oral Submucous Fibrosis (OSMF). Material and Methods: 120 subjects with clinic-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (oxitard) and Group B (lycopene). Group A was administered 2 oxitard capsules twice daily and Group B was given 8 mg lycopene in 2 divided doses of 4 mg for 3 months. Gingival index and plaque index were documented for all patients and compared. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Student’s paired t test and Chi-square test. P-value 0.001) among the 2 groups. Although the mean gingival index and plaque index in group A was reduced but it was found to be not statistically significant. Conclusion: Oxitard capsules can bring about significant clinical improvements in the symptoms like mouth opening, tongue protrusion, difficulty in swallowing and speech and pain associated with the lesion when compared to lycopene, thereby improving the quality of life of the affected individuals.

Effect of eclipta alba on scopolamine induced amnesia in mice

Abstract: The present study deals with the evaluation of potential effects of Eclipta alba (EA) in memory impairment of mice. Memory impairment was induced by scopolamine (3 mg/kg, i.p) in animals. To assess learning and memory in mice Morris water maze test was employed. The acetylcholinestrase enzyme (AChE) activity in brain was measured to evaluate the central cholinergic activity. The levels of thiobarbituric acid-reactive species (TBARS) and reduced glutathione (GSH)in brain were estimated to assess the degree of oxidative stress. Scopolamine treatment produces significant impairment of learning and memory in mice, as reflected by a significant decrease in MWM performance. Scopolamine also produced a significant enhancement of brain AChE activity and brain oxidative stress (increase in TBARS and decrease in GSH) levels. EA (300 and 600 mg/kg,oral) significantly prevented scopolamine-induced learning and memory deficits along with decrease of scopolamine-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that Eclipta alba has significant protective action against scopolamine induced memory deficits in mice that can be attributed to its anti AChE and anti oxidant actions. Keywords: Alzheimer disease, Oxidative stress, Morris water Maze, Scopolamine

Effect of Eclipta alba and Ocimum sanctum on haloperidol induced parkinsonism

Abstract: The aim of the study is protective effect of compound Eclipta alba and Ocimum sanctum on Parkinsonism induced mice by haloperidol injection. Parkinsonism is neurodegenerative disease due to the deficiency of dopamine in brain. The pathological hallmark of Parkinson’s disease in the cell loss within substantia nigra pars compacta (SNpc) region and the disease is charactrised by bradykinesia, rigidity, postural instability, orofacial dyskinesia, muscular stiffness and tremor1. Mice were injected 1mg/kg haloperidol and then treated with test and standard substance for 15 days. The impairment in catatonia in mice were tested using catatonic activity. Biochemical analysis of brain homogenate was performed so ass to assess brain Thiobarbituric acid reactive substance (TBARS) level and reduced glutathione (GSH) and TNF-α level were measured to assess total oxidative stress. EA 300mg/kg and OS 400mg/kg show slightly change in catatonic activity in mice while EA 600mg/kg and 800mg/kg significantly change in catatonic activity. Furthermore, Eclipta alba and Ocimum sanctum prevent the haloperidol induced changes in the level of brain TBARS, GSH and TNF-α. From the results we conclude that Eclipta alba and Ocimum sanctum has protective action against impairment in catatonic activity and pathological damage due to oxidative stress induced by intraperitoneally injection of haloperidol in mice. Keywords: Eclipta alba, Ocimum Sanctum, Parkinsonism, Anti-oxidant.

In-vitro free radical scavenging potential of flavonoids with synergistic effect of their combination

Abstract: The present study was carried out to evaluate the possible synergistic interactions on antioxidant efficacy of some selected flavonoids in the present study, synergistic antioxidant effects of two flavonoids, rutin and quercetin, have been investigated by. DPPH, NO, free radical scavenging assays. Biological free radicals are highly unstable molecules that react with various organic substrates such as lipids, proteins, DNA causing cellular injury. At high concentrations, they generate oxidative stress, a damaging process that can damage all cell structures. At present, the research is focused on the use of antioxidants in preventing many diseases caused by the free radicals. The study was designed to evaluate in vitro antioxidant potential of quercetin, rutin, individually and synergistic antioxidant effects by using various in-vitro antioxidant assays i.e. DPPH, NO, assays. The scavenging effect of quercetin, rutin and standard on the DPPH radical was 83±2.71 %, 79±1.51% and 86±1.04 % at 60μg/ml. On NO Quercetin, rutin and standard exhibited 83±0.09 %, 76±0.09 % and 85±0.22%. The scavenging activity increased in a dose dependent manner. The results indicate drugs shows significant free radical scavenging and their combination demonstrated considerable synergistic effect as compared to standard. Keywords: Quercetin, Rutin, Free radical scavenging, Antioxidant

A Contemplating approach for Hive and Map reduce for efficient Big Data Implementation.

Abstract: In the reference current scenario, data is incremented exponentially and speed of data accruing at the rate of petabytes. Big data defines the available amount of data over the different media or wide communication media internet. Big Data term refers to the explosion in the quantity (and quality) of available and potentially relevant data. On the basis of quantity amount of data are very huge and this quantity has been handled by conventional database systems and data warehouses because the amount of data increases similarly complexity with it also increases. Multiple areas are involved in the production, generation, and implementation of Big Data such as news media, social networking sites, business applications, industrial community, and much more. Some parameters concern with the handling of Big Data like Efficient management, proper storage, availability, scalability, and processing. Thus to handle this big data, new techniques, tools, and architecture are required. In the present paper, we have discussed different technology available in the implementation and management of Big Data. This paper contemplates an approach formal tools and techniques used to solve the major difficulties with Big Data, This evaluate different industries data stock exchange to covariance factor and it tells the significance of data through covariance positive result using hive approach and also how much hive approach is efficient for that in the term of HDFS and hive query. and also evaluates the covariance factors after applying hive and map reduce approaches with stock exchange dataset of around 3500.After process data with the hive approach we have conclude that hive approach is better than map reduce and big table in terms of storage and processing of Big Data.

Overview of Concept Drifts Detection Methodology in Data Stream

Abstract: Real-time online applications and mobile data generate huge volume of data. There is a need to process this data into compact data structures and extract meaningful information. A number of approaches have been proposed in literature to overcome the issues of data stream mining. This chapter summarizes various issues and application techniques. The chapter is a guideline for research to identify the research issues and select the most appropriate method in order to detect and process novel class.

A comparative study of cone-beam computed tomography and intrasurgical measurements of intrabony periodontal defects

Abstract: Objective: The objective of this study was to analyze the correlation between cone-beam computed tomography (CBCT) measurements and intrasurgical measurements of intrabony periodontal defects. Materials and Methods: Thirty-two patients with intrabony defects, who underwent periodontal therapy and were advised for surgical therapy, were included in this study. Diagnostic images were obtained by periapical radiographs and CBCT before the surgical procedure. The distance from the cementoenamel junction to the base of the periodontal defect (CEJ–BD), the distance from the crest of bone to the deepest point of the defect, and mesiodistal (M-D) width of the periodontal defect were measured on CBCT and periapical radiographs during the surgical procedure. The faciolingual width of the defect was only measured on CBCT images during the surgical procedure. The linear measurements obtained during the surgical therapy were compared with that obtained by intraoral radiographs and CBCT imaging. Results: The M-D width of the defect measured during the surgical procedure was similar to that measured on the periapical radiograph. The distance of CEJ to BD and the distance from the crest of bone to the deepest point of the defect measured on the periapical radiographs were less than that of intrasurgical measurements. No significant difference was noted regarding the CBCT measurements of the faciolingual width and M-D width of the defect when compared with the measurements obtained during the surgical procedures. A significant difference was noted in the CBCT measurements from the CEJ to BD and the distance from the crest of bone to the deepest point of the defect when compared with the intrasurgical measurements. Conclusion: CBCT may lend comparatively discriminative dimensions of the periodontal defect similar to that of intrasurgical measurements.

Formulation and evaluation of gastroretentive floating tablets of lafutidine

Abstract: The purpose of this research was to develop a novel gastroretentive drug delivery system based on wet granulation technique for sustained delivery of active agent. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Gastroretentive floating tablets, which was designed to provide the desired sustained and complete release of drug for prolonged period of time. Gastroretentive floating tablets of lafutidine were prepared by wet granulation technique using different concentrations of Gum Kondagagu, Gum olibanum and Locust bean Gum. The optimized formulation (LF14) exhibited 99.54% drug release in 12 hrs, while the buoyancy lag time was 33 sec. In-vitro drug release kinetics was found to follow both the Zero order and the possible mechanism of lafutidine release from the optimized formulation might be attributed to super case II transport mechanism. The Optimized formulation (LF14) showed no significant change in physical appearance, drug content, floating lag time, in vitro dissolution studies after 75%±5% RH at 40±20C relative humidity for 6 months. Keyword: Wet granulation, Floating lag Time, Gastroretentive, Lafutidine