Jodhpur National University

About: Jodhpur National University is a education organization based out in Jodhpur, India. It is known for research contribution in the topics: Transdermal & Self-healing hydrogels. The organization has 160 authors who have published 216 publications receiving 2381 citations.

Prevalence and the relationship of oral mucosal lesions in tobacco users and denture wearers in the North Indian population.

Abstract: Aim: The aim of the present study was to determine the prevalence and the relationship of oral mucosal lesions in tobacco users and denture wearers in a North Indian population. Materials and Methods: The study comprised 3,749 patients attending the Department of Oral Medicine and Radiology, Jodhpur Dental College General Hospital between September 2008 and December 2012, for the treatment of dental problems other than oral mucosal lesions. The ages ranged from 28 years to 83 years, with a mean age of 49.7 years. The results were evaluated using the Pearson Chi-square test, with Yate's correction and ANOVA tests. Results: A total of 2,318 patients were diagnosed with lesions associated with the use tobacco and the wearing of dentures. The most frequently seen lesion was melanin pigmentation (29.9%) followed by linea alba (22.2%) and frictional keratosis (19.9%). Ulcers (6.1%) were the most common oral lesion seen in patients who wore dentures, followed by hyperplasia (4.8%). A statistically significant relation (P < 0.05) was established between tobacco and melanin pigmentation, frictional keratosis, traumatic ulcerations and leukoplakia. In those who wore dentures a statistically significant relation (P < 0.05) was found between candidiasis, traumatic ulceration and frictional keratosis. Conclusion: The results of the present study indicate that the association of frictional keratosis with tobacco users and wearers of dentures can help in determining the diagnosis and treatment plan for oral cancer. Wearers of dentures should also be recalled for periodic checks at regular intervals and optimum preventive measures implemented.

Fracture resistance of endodontically treated permanent anterior teeth restored with three different esthetic post systems: An in vitro study.

Abstract: Background: Esthetic coronal reconstruction of fractured anterior teeth is often performed using intra radicular posts. Most of the commonly used commercially esthetic post systems do not exhibit similar physical properties as dentin resulting in failures. Aim: To evaluate and compare the fracture resistance and mode of failure of simulated traumatized permanent central incisors restored with three different post systems including biologic dentin posts. Materials and Methods: A total of 40 recently extracted human maxillary central incisors with similar dimensions were decoronated 2 mm above the cemento-enamel junction and endodontically treated. Ten specimens were randomly selected as the Group I - Control group (core built teeth without intraradicular posts). The remaining 30 teeth were equally divided and restored with zirconia (Group II, n = 10), fiber re-inforced composite (FRC) (Group III, n = 10) and biologic dentin posts (Group IV, n = 10) using resin bonded cement and their cores built-up. These samples were embedded in acrylic resin and then secured in a Universal Testing Machine and subjected to fracture resistance testing. The location of failure in the specimens was evaluated using a stereomicroscope. Results: Intergroup comparison revealed that the control group and zirconia post group (522 ± 110 N) demonstrated the least fracture resistance, while dentin post group (721 ± 127 N) the highest. There was no statistically significant difference between fiber post and dentin post groups. Fractures that were repairable were observed in fiber post and dentin post groups, whereas mostly unrestorable, catastrophic fractures were observed in the zirconia post group. Conclusion: Teeth restored with the biologic dentin post system demonstrated the highest fracture resistance and repairable fractures, closely followed by FRC post system. The least fracture resistance and most catastrophic fractures were demonstrated by the zirconia post system.

RP-HPLC method for simultaneous estimation of nitazoxanide and ofloxacin in tablets

Abstract: A reverse phase high performance liquid chromatography method was developed for simultaneous estimation of nitazoxanide and ofloxacin in tablet formulation. The separation and quantification was achieved by Hiq Sil C18 V Size 4.6 mm O *250 mm column in isocratic mode, with mobile phase consisting of acetonitrile-methanol-0.4 M citric acid, (60:30:10, v/v/v). Citric acid used to stabilize nitazoxanide and ofloxacin in mobile phase. The mobile phase was pumped at a rate of 0.6 ml/min and the detection was carried out at 304 nm. The retention time of ofloxacin and nitazoxanide was found to be 3.122 and 5.902 min, respectively. The method was validated for linearity, accuracy, and precision. Linearity for ofloxacin and nitazoxanide were in the range 2-36 mg/ml and 5-90 mg/ml, respectively. The developed method was found to be accurate, precise and selective for simultaneous estimation of ofloxacin and nitazoxanide in tablets.

Evaluation of diuretic activity of different extracts of Mimosa pudica Linn.

Abstract: In that study, Mimosa pudica linn was tested for diuretic activity using the lipschitz test. The ethanolic and aqoues extract of Mimosa pudica Linn. was studied at two dose level 100 and 200 mg kg(-1) b.wt. Furosemide (20 mg kg(-1) b.wt.) was used as standard drug in a 0.9% saline solution. Urine volumes were measured for all the groups up to 5 h. The ethanolic extract of Mimosa pudica linn was exhibited significant diuretic activity at doses of 100 and 200 mg kg(-1) b.wt. by increasing total urine volume and ion concentration of Na+ k+ and Cl-.