Jodhpur National University

About: Jodhpur National University is a education organization based out in Jodhpur, India. It is known for research contribution in the topics: Transdermal & Self-healing hydrogels. The organization has 160 authors who have published 216 publications receiving 2381 citations.

Enhancement of Transdermal Permeation of Indinavir Sulfate via EthosomeVesicles

Abstract: The aim of the present study is to investigate the potential of ethosomal formulations for transdermal delivery of indinavir sulphate from ethosomes. Vesicles containing phosphatidylcholine mixed with ethanol and indinavir sulphate were prepared by conventional mechanical stirrer method and characterized by various parameters (vesicles shape and surface morphology, size and size distribution, entrapment efficiency, elasticity, turbidity and in vitro drug release). The effect of different formulation variable on skin permeation of indinavir sulphate was studied via synthetic semipermeable membrane or skin of new born mice by using diffusion cell. The selected system were incorporated into carbopol 934P gel and evaluated for both drug permeation and mice skin deposition. The optimized ethosomal formulation showed transdermal flux of 25.01±0.34 μg/cm2 /h across rat skin as compared to 2.98±0.21μg/cm2 /h for plane drug solution, 4.28±0.54 μg/cm2 /h for hydroethanolic solution and 9.7±0/21 μg/cm2 /h for classical liposomes. The obtained flux was nearly 7.5 and 12.04 times higher than conventional liposomal formulation bearing indinavir sulphate and plain drug solution. These results suggest that ethosomes are potential vehicles for improved transdermal delivery of indinavir sulphate.

Standardization, development and validation of spectrophotometric method for simultaneous estimation of embelin and gallic acid as individual and in combination in ayurvedic churna formulation

Abstract: Objectives: A new simple spectrophotometric method for simultaneous estimation of Embelin and Gallic Acid in Vidang, Harade and Vidangadi Churna was investigated. The λmax of Embelin and Gallic Acid were found to be 341 and 258 nm. Method: The graphical absorbance ratio method was used for simultaneous estimation of Embelin and Gallic acid in Vidangadi Churna, and the Isoabsorbtive point for simultaneous estimation of both the drug were found to be 307.5 nm. The method obeys Beers law in the concentration range from 2-12 μg/ml. The correlation coefficient was found to be 0.9973 for Embelin and 0.998 for Gallic Acid. The method was validated as per ICH guidelines. Results: The result of estimation of Embelin in Vidang, Gallic acid in Harade and both in Vidangadi Churna were found to be 1.05 percent, 1.04 percent, and 1.85. The proposed method was validated for linearity, accuracy and application for assay as per ICH guidelines. Conclusion: The study showed good reproducibility and recovery with percent RSD less than 2. So, the proposed method was found to be simple, specific, precise, and accurate. Hence it can be applied for simultaneous estimation of Embelin and Gallic Acid in various Ayurvedic Churna formulations. Key Word : Embelin, Vidang. Gallic Acid, Harade, Vidangadi Churna.

Nationwide Survey of Fifth-Year Dental Students’ Perceptions About Tobacco Prevention, Control, and Curriculum in India

Abstract: The objective of this study was to assess the tobacco cessation knowledge, attitudes, practices, and perceived barriers of dental interns (students in their last year of the five-year dental curriculum) in India as well as to assess the adequacy of training in tobacco use cessation (TUC) counselling. This was a cross-sectional questionnaire study conducted with 1,521 interns at fiftyone dental colleges of India selected by multistage random sampling. The survey instrument was a fifty-nine-item, self-structured, and self-administered questionnaire. Fifteen questions were about knowledge and attitudes, with twenty-two about practices, fifteen about barriers, and seven about curriculum adequacy; demographic data were also collected. The response rate was 99.7 percent. The results showed that 38.8 percent had knowledge, 30.8 percent had positive attitudes, 19.2 percent practiced TUC, 43 percent experienced barriers, and 85.2 percent agreed on receiving extensive curriculum on tobacco cessation. Only 1 percent were aware of the 5As, the 5Rs protocol, and the motivational interviewing technique of TUC. These respondents' knowledge, attitudes, and practices were below normative level, and they took a superficial approach to TUC. The perceived barriers were very high and included curriculum inadequacy. The results of this study help show there is an urgent need to revise the tobacco curriculum in dental schools in India to make students more confident to practice this aspect of dentistry independently.

Genetic predisposition to oxcarbazepine induced Stevens-Johnson syndrome.

Abstract: Stevens-Johnson syndrome (SJS) is a rare immunologic reaction that may involve skin or various mucosal surfaces. The etiology may range from multiple pharmacologic agents to viral infections. Associated findings can range from minimal skin and mucosal involvement to extensive dermal exfoliation, nephritis, lymphadenopathy, hepatitis, and multiple serologic abnormalities. We report a female patient of 38 years with a history of drug allergy who was administered oxcarbazepine for the management of right partial bronchial seizure due to left parasagittal mass lesion following which she developed papular rashes all over the body and diagnosed as SJS. Although carbamazepine (CBZ) is the most common cause of SJS, a new anticonvulsant, oxcarbazepine, which is structurally related to CBZ, has been shown to induce SJS.

Simultaneous 12-lead QRS detection by K-means clustering algorithm

Abstract: An electrocardiogram (ECG) is a recording of the electrical activity of the heart. Analysis of ECG data can give important information about the health and condition of the heart and can help physicians to diagnose cardiac arrhythmias, acute myocardial infarctions, conduction abnormalities, and many other heart diseases. ECGs can also be used to determine heart rate by calculating the time between successive QRS complexes. This paper presents an application of K-means algorithm applied on 25 subjects of CSE data set-3 for the detection of QRS complexes in the simultaneously recorded 12 lead ECG. The detection rate of 99.89% is achieved.