Institution
John Radcliffe Hospital
Healthcare•Oxford, Oxfordshire, United Kingdom•
About: John Radcliffe Hospital is a healthcare organization based out in Oxford, Oxfordshire, United Kingdom. It is known for research contribution in the topics: Population & Antigen. The organization has 14491 authors who have published 23670 publications receiving 1459015 citations.
Topics: Population, Antigen, Transplantation, Cytotoxic T cell, Immune system
Papers published on a yearly basis
Papers
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John Radcliffe Hospital1, Medpace2, University of Miami3, University of Oxford4, University of Western Ontario5, University of Chicago6, University of Pennsylvania7, Medical University of Vienna8, Icahn School of Medicine at Mount Sinai9, University of Cincinnati10, Ohio State University11, Paris Diderot University12, University of California, San Diego13
TL;DR: The UCEIS and its components show satisfactory intrainvestigator and interinvestigator reliability and was unaffected by knowledge of clinical details when assessing the endoscopic severity of UC.
337 citations
TL;DR: The 5-methyltetrahydrofolfolate (5-MTHF) may have beneficial effects on endothelial function; however, its mechanisms of action remain uncertain this article.
Abstract: Background— The circulating form of folic acid, 5-methyltetrahydrofolate (5-MTHF), may have beneficial effects on endothelial function; however, its mechanisms of action remain uncertain. Decreased...
337 citations
TL;DR: It is shown that PSF1 is necessary for the efficient assembly of class I molecules and enables them to present a peptide epitope derived from endogenously synthesized viral antigen.
Abstract: Major histocompatibility complex (MHC) class I molecules present peptides derived from the endogenous protein pool to cytotoxic T lymphocytes, which can thus recognize intracellular antigen. This pathway may depend on a transporter (PSF1) to mediate entry of the cytosolic peptides into a pre-Golgi compartment where they bind to class I heavy chains and promote their stable assembly with beta 2-microglobulin. There is, however, only indirect support for this function of PSF1. Here we show that PSF1 is necessary for the efficient assembly of class I molecules and enables them to present a peptide epitope derived from endogenously synthesized viral antigen. Immunochemical and genetic data demonstrate that the PSF1 polypeptide is associated with a complementary transporter chain, which is polymorphic and is encoded by the PSF2 gene, which is closely linked to PSF1.
336 citations
TL;DR: Although the usefulness of the diagnostic rule will vary depending on the prevalence of tuberculosis and HIV-1 infection, it is suggested it be applied to adults with meningitis and a low cerebrospinal fluid glucose, particularly in settings with limited microbiological resources.
336 citations
TL;DR: D14 is high in the vasculature of xenograft human tumors in the mouse, in endogenous human tumors and is regulated by hypoxia, and possible new targets for antiangiogenic tumor therapy are suggested.
336 citations
Authors
Showing all 14542 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Douglas G. Altman | 253 | 1001 | 680344 |
| Salim Yusuf | 231 | 1439 | 252912 |
| David J. Hunter | 213 | 1836 | 207050 |
| Mark I. McCarthy | 200 | 1028 | 187898 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Richard Peto | 183 | 683 | 231434 |
| Ralph M. Steinman | 171 | 453 | 121518 |
| Adrian L. Harris | 170 | 1084 | 120365 |
| Rory Collins | 162 | 489 | 193407 |
| Nicholas J. White | 161 | 1352 | 104539 |
| David W. Johnson | 160 | 2714 | 140778 |
| David Cella | 156 | 1258 | 106402 |
| Edmund T. Rolls | 153 | 612 | 77928 |
| Martin A. Nowak | 148 | 591 | 94394 |
| Kypros H. Nicolaides | 147 | 1302 | 87091 |