scispace - formally typeset
Search or ask a question
Institution

John Radcliffe Hospital

HealthcareOxford, Oxfordshire, United Kingdom
About: John Radcliffe Hospital is a healthcare organization based out in Oxford, Oxfordshire, United Kingdom. It is known for research contribution in the topics: Population & Antigen. The organization has 14491 authors who have published 23670 publications receiving 1459015 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: The finding that the TAXUS Moderate Release stent system is safe and effective in the treatment of long, complex coronary artery lesions provides the evidence base for the more widespread use of drug-eluting stents in contemporary clinical practice.
Abstract: Background— Intracoronary polymer-based stent delivery of paclitaxel has been shown to be effective in reducing restenosis in simple coronary lesions, but the evidence base for contemporary use in longer, more complex coronary stenoses is lacking. Methods and Results— TAXUS VI is a prospective, multicenter, double-blind, randomized trial assessing clinical and angiographic outcomes of the TAXUS Moderate Release paclitaxel-eluting stent in the treatment of long, complex coronary artery lesions. Four hundred forty-eight patients at 44 sites were randomized (1:1) between a drug-eluting TAXUS Express2 and an uncoated Express2 control stent. Per protocol, the 9-month follow-up included an angiographic reevaluation in all patients. The primary end point was the rate of target-vessel revascularization 9 months after the study procedure; secondary end points included the rate of target-lesion revascularization and binary restenosis at follow-up. Mean lesion length in the study was 20.6 mm, with a mean stent-cover...

336 citations

Journal ArticleDOI
TL;DR: The burden of human suffering caused by snake bite remains un-recognised, invisible, and unheard by the global public health community, forgotten by development agencies and governments alike.

335 citations

Journal ArticleDOI
24 Nov 1983-Nature
TL;DR: A human α2-globin gene is identified which contains a single point mutation in this hexanucleotide (AATAAA → AATAAG), and readthrough transcripts extending beyond the normal poly(A) addition site are detected in mRNA obtained from HeLa cells transfected with cloned DNA from the mutant α2 gene, suggesting that the single nucleotide change in the AATAAA sequence is the cause of its abnormal expression.
Abstract: Most eukaryotic messenger RNAs have the sequence AAUAAA 11–30 nucleotides from the 3′-terminal poly(A) tract1,2. Since this is the only significant sequence homology in the 3′ non-coding region it has been suggested that it may be a recognition site for enzymes involved in polyadenylation and/or termination of polymerase II transcription2–4. This idea is strengthened by observations on the effect of deletion mutations in or around the AATAAA sequence on polyadenylation of late simian virus 40 (SV40) mRNA; removal of this sequence prevents poly(A) addition3. Naturally occurring variants ofthis hexanucleotide are rare5–11 and hitherto their functional significance has not been assessed. We have now identified a human α2-globin gene which contains a single point mutation in this hexanucleotide (AATAAA → AATAAG). The paired α1 gene on the same chromosome is completely inactivated by a frame-shift mutation. This unique combination has enabled the expression of the mutant α2 gene to be studied in vivo where it has been found that the accumulated level of α2-specific mRNA in erythroid cells is reduced. Furthermore, readthrough transcripts extending beyond the normal poly(A) addition site are detected in mRNA obtained from HeLa cells transfected with cloned DNA from the mutant α2 gene, suggesting that the single nucleotide change in the AATAAA sequence is the cause of its abnormal expression.

335 citations

Journal ArticleDOI
01 Dec 1999-Immunity
TL;DR: A unique role is defined in the generation of optimal CD4+ T cell responses in vivo by finding that the formation of extrafollicular plasma cells, germinal centers, and antibody responses was independent of OX40.

335 citations

Journal ArticleDOI
05 Aug 1999-Nature
TL;DR: The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function.
Abstract: Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.

335 citations


Authors

Showing all 14542 results

NameH-indexPapersCitations
Douglas G. Altman2531001680344
Salim Yusuf2311439252912
David J. Hunter2131836207050
Mark I. McCarthy2001028187898
Stuart H. Orkin186715112182
Richard Peto183683231434
Ralph M. Steinman171453121518
Adrian L. Harris1701084120365
Rory Collins162489193407
Nicholas J. White1611352104539
David W. Johnson1602714140778
David Cella1561258106402
Edmund T. Rolls15361277928
Martin A. Nowak14859194394
Kypros H. Nicolaides147130287091
Network Information
Related Institutions (5)
Leiden University Medical Center
38K papers, 1.6M citations

94% related

Medical Research Council
19.1K papers, 1.4M citations

92% related

Beth Israel Deaconess Medical Center
52.5K papers, 2.9M citations

92% related

Brigham and Women's Hospital
110.5K papers, 6.8M citations

92% related

Baylor College of Medicine
94.8K papers, 5M citations

91% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202311
202252
20211,048
20201,013
2019916
2018773