Jordan University of Science and Technology

About: Jordan University of Science and Technology is a education organization based out in Irbid, Irbid, Jordan. It is known for research contribution in the topics: Population & Health care. The organization has 7582 authors who have published 13166 publications receiving 298158 citations. The organization is also known as: JUST.

Immunotherapy for HER2-positive breast cancer: recent advances and combination therapeutic approaches.

Abstract: Cancer immunotherapy has evolved dramatically with improved understanding of immune microenvironment and immunosurveillance. The immunogenicity of breast cancer is rather heterogeneous. Specific subtypes of breast cancer such as estrogen receptor (ER)-negative, human EGF receptor 2 (HER2)-positive, and triple-negative breast cancer (TNBC) have shown evidence of immunogenicity based on tumor-immune interactions. Several preclinical and clinical studies have explored the potential for immunotherapy to improve the clinical outcomes for different subtypes of breast cancer. This review describes the immune microenvironment of HER2-positive breast cancer and summarizes recent clinical advances of immunotherapeutic treatments in this breast cancer subtype. The review provides rationale and ongoing clinical evidence to the use of immune checkpoint inhibitors, therapeutic vaccines, and adoptive T cell immunotherapy in breast cancer. In addition, the present paper describes the most relevant clinical progress of strategies for the combination of immunotherapy with standard treatment modalities in HER2-positive breast cancer including chemotherapy, targeted therapy, and radiotherapy.

The prevalence and pattern of hypodontia of the permanent teeth and crown size and shape deformity affecting upper lateral incisors in a sample of Jordanian dental patients.

Abstract: OBJECTIVE The aim of this study was to determine the prevalence and pattern of hypodontia and the extent of congenital malformation in the permanent teeth of a sample of Jordanian adults. MATERIAL AND METHODS Clinical examinations were carried out on 1045 dental patients aged 16 to 45 years to record any congenital absence of teeth except 3rd molars and to note any crown shape or size deformities affecting the upper lateral incisor. The congenital absence of permanent teeth was confirmed by taking complete dental history and orthopantomograms. Impacted teeth and teeth lost as a consequence of extraction or trauma were recorded as present. RESULTS The prevalence of hypodontia was found to be 5.5% of the sample and the lower second premolar was the most frequently missing tooth. The number of missing upper lateral incisors was significantly higher than that of lower lateral incisors, (p < 0.05). Peg-shaped and reduced size upper lateral incisors were observed in 2.3% and 2.9% of the sample respectively. There were no significant differences according to gender, location of tooth according to arch or side of the jaw and hypodontic pattern. CONCLUSION The prevalence of hypodontia was 5.5%, that of peg-shaped lateral incisor was 2.3% and that of reduced crown size was 2.9%.

Lack of effectiveness of dexamethasone in neonatal bacterial meningitis.

Abstract: A clinical trial was conducted to determine whether dexamethasone as adjunctive therapy alters the outcome of bacterial meningitis in neonates. Fifty-two full-term neonates with bacterial meningitis were enrolled in a prospective study. Infants were alternately assigned to receive either dexamethasone or not. Twenty-seven received dexamethasone in addition to standard antibiotic treatment and 25 received antibiotics alone. Dexamethasone therapy was started 10–15 min before the first dose of antibiotics in a dose of 0.15 mg/kg per 6 h for 4 days. Baseline characteristics, clinical and laboratory features in the two groups were virtually similar. Both groups showed a similar clinical response and similar frequency of mortality and sequelae. Six (22%) babies in the treatment group died compared to 7 (28%) in the control group (P = 0.87). At follow up examinations up to the age of 2 years, 6 (30%) of dexamethasone recipients and 7 (39%) of the control group had mild or moderate/severe neurological sequelae. Audiological sequelae were seen in two neonates in the dexamethasone group compared to one in the control group.