Institution
Jordan University of Science and Technology
Education•Irbid, Irbid, Jordan•
About: Jordan University of Science and Technology is a education organization based out in Irbid, Irbid, Jordan. It is known for research contribution in the topics: Population & Medicine. The organization has 7582 authors who have published 13166 publications receiving 298158 citations. The organization is also known as: JUST.
Topics: Population, Medicine, Health care, Heat transfer, Cloud computing
Papers published on a yearly basis
Papers
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TL;DR: It is expected that an improved understanding of the nature of Cronobacter persistence may aid in further improved control measures and eliminate the bacterium from the critical food production environments.
127 citations
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TL;DR: This review focuses on the prognostic significance of FGF2 in cancer with emphasis on therapeutic intervention strategies for solid and hematological malignancies.
Abstract: // Mohamed R. Akl 1 , Poonam Nagpal 1 , Nehad M. Ayoub 2 , Betty Tai 1 , Sathyen A. Prabhu 1 , Catherine M. Capac 1 , Matthew Gliksman 1 , Andre Goy 3 and K. Stephen Suh 1 1 Genomics and Biomarkers Program, The John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA 2 Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan 3 Lymphoma Division, The John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA Correspondence to: K. Stephen Suh, email: // Keywords : bFGF, FGF2, diagnosis, prognosis, malignancy, Received : October 20, 2015 Accepted : March 10, 2016 Published : March 19, 2016 Abstract Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by binding to heparan sulfate and FGF receptors (FGFR) with varying affinities. FGF2 is the prototype member of the FGF family and interacts with its receptor to mediate receptor dimerization, phosphorylation, and activation of signaling pathways, such as Ras-MAPK and PI3K pathways. Excessive mitogenic signaling through the FGF/FGFR axis may induce carcinogenic effects by promoting cancer progression and increasing the angiogenic potential, which can lead to metastatic tumor phenotypes. Dysregulated FGF/FGFR signaling is associated with aggressive cancer phenotypes, enhanced chemotherapy resistance and poor clinical outcomes. In vitro experimental settings have indicated that extracellular FGF2 affects proliferation, drug sensitivity, and apoptosis of cancer cells. Therapeutically targeting FGF2 and FGFR has been extensively assessed in multiple preclinical studies and numerous drugs and treatment options have been tested in clinical trials. Diagnostic assays are used to quantify FGF2, FGFRs, and downstream signaling molecules to better select a target patient population for higher efficacy of cancer therapies. This review focuses on the prognostic significance of FGF2 in cancer with emphasis on therapeutic intervention strategies for solid and hematological malignancies.
126 citations
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TL;DR: Although all 4 viruses tested share high genetic similarity in all 8 genes, only the Ohio strain was shown to transmit efficiently both ways between swine and turkeys, and one isolate was able to transmit from pigs to turkeys but not vice versa.
Abstract: The triple reassortant H3N2 viruses were isolated for the first time from pigs in 1998 and are known to be endemic in swine and turkey populations in the United States. In 2004, we isolated two H3N2 triple reassortant viruses from two turkey breeder flocks in Ohio and Illinois. Infected hens showed no clinical signs, but experienced a complete cessation of egg production. In this study, we evaluated three triple reassortant H3N2 isolates of turkey origin and one isolate of swine origin for their transmission between swine and turkeys. Although all 4 viruses tested share high genetic similarity in all 8 genes, only the Ohio strain (A/turkey/Ohio/313053/04) was shown to transmit efficiently both ways between swine and turkeys. One isolate, A/turkey/North Carolina/03, was able to transmit from pigs to turkeys but not vice versa. Neither of the other two viruses transmitted either way. Sequence analysis of the HA1 gene of the Ohio strain showed one amino acid change (D to A) at residue 190 of the receptor binding domain upon transmission from turkeys to pigs. The Ohio virus was then tested for intraspecies transmission in three different avian species. The virus was shown to replicate and transmit among turkeys, replicate but does not transmit among chickens, and did not replicate in ducks. Identifying viruses with varying inter- and intra-species transmission potential should be useful for further studies on the molecular basis of interspecies transmission.
126 citations
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TL;DR: The effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions is assessed.
126 citations
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University of Cologne1, Jordan University of Science and Technology2, University of Tübingen3, University of Amsterdam4, Technische Universität München5, University of Erlangen-Nuremberg6, Paracelsus Private Medical University of Salzburg7, University of Marburg8, University of Duisburg-Essen9, Heidelberg University10, University of Würzburg11
TL;DR: In early-stage favorable HL, a positive PET after two cycles ABVD indicates a high risk for treatment failure, particularly when a Deauville score of 4 is used as a cutoff for positivity in PET-2-positive patients.
Abstract: PURPOSECombined-modality treatment (CMT) with 2× ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and small-field radiotherapy is standard of care for patients with early-stage favorable...
125 citations
Authors
Showing all 7666 results
Name | H-index | Papers | Citations |
---|---|---|---|
Andrew McCallum | 113 | 472 | 78240 |
Yousef Khader | 94 | 586 | 111094 |
Michael P. Jones | 90 | 707 | 29327 |
David S Sanders | 75 | 639 | 23712 |
Nidal Hilal | 72 | 395 | 21524 |
Nagendra P. Shah | 71 | 334 | 19939 |
Jeffrey R. Idle | 70 | 261 | 16237 |
Rahul Sukthankar | 70 | 240 | 28630 |
Matthias Kern | 66 | 332 | 14871 |
David De Cremer | 65 | 297 | 13788 |
Moustafa Youssef | 61 | 299 | 15541 |
Mohammed Farid | 61 | 299 | 15820 |
Rudolf Holze | 58 | 388 | 13761 |
Rich Caruana | 57 | 145 | 26451 |
Eberhardt Herdtweck | 56 | 332 | 10785 |