Showing papers by "Jožef Stefan Institute published in 1985"
TL;DR: Antibodies against human placental UK-I completely quenched the inhibitory activity of human leucocyte UK-B and inactivated outside the pH range 7-9.7.
Abstract: A plasminogen activator inhibitor (PA-I) which inhibits primarily plasminogen activator of the urokinase type (u-PA) was isolated from the cytosol of human peripheral leukocytes. The inhibitor was isolated using ion exchange chromatography, gel filtration and FPLC. This inhibitor has an apparent molecular weight of 45 kDa, determined by SDS-PAGE, and a pI of 5.5-5.7. The inhibitor is a fast reacting inhibitor, is thermally unstable and is inactivated outside the pH range 7-9. Treatment of cytosol to pH 9 for 30 min at 37 degrees C resulted in a large increase in inhibitory activity. Antibodies against human placental UK-I completely quenched the inhibitory activity of human leucocyte UK-I.
52 citations
TL;DR: In this paper, a critical evaluation of the toughness of Al 2 O 3 ZrO 2 composites was undertaken. And the authors concluded that microcracking is the slightly more effective mechanism and that the present results may be interpreted on the basis of existing theories.
44 citations
TL;DR: The difference between urethral pressures measured along the anterior wall and those measuredAlong the posterior wall was found to increase markedly as the stiffness of the catheter was increased and to increase by a greater amount if the weight of theCatheters was increased.
Abstract: The difference between urethral pressures measured along the anterior wall and those measured along the posterior wall was found to increase markedly as the stiffness of the catheter was increased and to increase by a greater amount if the weight of the catheter was increased. A method of grading the stiffness of catheters is proposed and the use of stiff catheters in past reports of urethral measurements is discussed.
30 citations
TL;DR: Although cathepsin E is present in trace amounts in spleen from several species, it was found in large amounts in rat spleen, which can be correlated with the fact that spleen in the rat is an important organ in haemopoeisis.
17 citations
TL;DR: KARDIO-E can be used as a helpful diagnostic tool in the routine assessment of ECG recordings in preventive or systematic examinations as, by cardiologist's estimation, its performance is equivalent to that of a specialist of internal medicine highly skilled in the reading ofECG recordings.
Abstract: KARDIO-E is an expert system for the electrocardiographic diagnosis of heart arrhythmias. AT the present stage the system can be used as a helpful diagnostic tool in the routine assessment of ECG recordings in preventive or systematic examinations as, by cardiologist's estimation, its performance is equivalent to that of a specialist of internal medicine (non-cardiologist) highly skilled in the reading of ECG recordings. The system is also useful for instruction of electrocardiography in education of all medical profiles. This paper presents the ECG diagnosis problem, the automatic generation of the system's knowledge base and a detailed description of the system. Results of on assessment study are also presented.
16 citations
TL;DR: It is found that tubulin breakdown is heterogeneous, that membrane-bound tubulin is resistant to cathepsin D but susceptible to thrombin, and that cytoplasmic tubulin was in at least two pools, one with a higher, another with a lower, rate of breakdown.
15 citations
9 citations
TL;DR: The two forms from bovine spleen are closely similar in secondary structure content, in aromatic amino acid environment and in the two step denaturation behaviour.
Abstract: Cathepsin D occurs in two forms, a single polypeptide chain (Mr 44000) and a non-covalent complex of two peptides of Mr 14000 and 30000 that is derived by proteolytic processing of the 44000 polypeptide. The two forms from bovine spleen are closely similar in secondary structure content, in aromatic amino acid environment and in the two step denaturation behaviour. Enzyme activity is lost irreversibly on denaturation but conformation can be partially regained. The two separated chains will only refold partially and this is related to their positions in the overall structure of cathepsin D. It is suggested that the processing step is related to protein turnover.
8 citations
TL;DR: In this paper, the results of the Mossbauer data were compared with those for SnF 2, SnF·MF 6 and Sn(SbF 6 ) 2, and they showed that the reaction of SnF ·MF 6 with snF 2 in liquid SO 2 also produces the [Sn 2 F 3 ] [MF 6 ] salt.
6 citations
TL;DR: In this paper, it has been shown that (n 2 H 5 ) 2 GeF 6 and (N 2 H 6 ) 2 (GeF 6 )F 2 are monoclinic, space group P 2 1 /n, with unit-cell dimensions a = 6.015, b = 5.249, c = 11.181, β = 100.15, and Z = 2.
5 citations
TL;DR: In this paper, a variational method for calculating the ground state and the scattering states in the model with a pion cloud around a bare nucleon and bare delta is presented, with three free parameters: the bare coupling constant, the bag radius and the energy of the bare delta.
TL;DR: In this paper, the Mossbauer spectrum of BaFe 4 Sn 2 O 11 has been recorded for both 57 Fe and 119 Sn isotopes at a variety of temperatures, and a magnetic hyperfine field of 45 kG is transferred to the tin nuclei.
TL;DR: Tomatines are bioconverted by Nocardia restricta to less polar products by conjugation with l (+)‐lactic acid, depending on the length of the sugar‐chain.
Abstract: Tomatines are bioconverted by Nocardia restricta to less polar products by conjugation with l (+)-lactic acid. The yields of these bioconversions decrease from 50% with α-tomatine to 5% with δ-tomatine, depending on the length of the sugar-chain.
TL;DR: The external urethral meatus (EUM) was located on the Urethral closure pressure profile by simultaneous measurement of the urethRAL electric conductance profile by simultaneously measurement ofThe EUM was further used as a reference point for accurate superimposition of urethrals closure pressure profiles.
Abstract: The external urethral meatus (EUM) was located on the urethral closure pressure profile by simultaneous measurement of the urethral electric conductance profile. The EUM was further used as a reference point for accurate superimposition of urethral closure pressure profiles.
TL;DR: The thermal decomposition of the complexes (N 2 H 6 ) 2 (GeF 6 F 2 ) 2 and N 2 H 5 ) 2 GeF 6 have been investigated by TG, DTG and DTA measurements.
TL;DR: In this paper, the advantages and disadvantages of the combination of KrF 2 and XeF 6 for the generation of salts with the transition metal fluoroanion in a novel oxidation state was discussed.
TL;DR: In this paper, bilinear pulses were used to selectively flip only distant protons thus eliminating most homonuclear couplings in the presence of nonuniform one-bond coupling constants.
TL;DR: In this paper, a black-box procedure for macroeconomic model synthesis is presented, based on the assumption that within the set of explanatory variables usually used in large econometric models a subset of significant variables can be found which contains enough information to describe the entire system.