Institution
Jožef Stefan Institute
Facility•Ljubljana, Slovenia•
About: Jožef Stefan Institute is a facility organization based out in Ljubljana, Slovenia. It is known for research contribution in the topics: Liquid crystal & Dielectric. The organization has 3828 authors who have published 12614 publications receiving 291025 citations.
Papers published on a yearly basis
Papers
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TL;DR: Recent findings on hypoxia-related oxidative stress modulation by different activity levels during prolonged hypoxic exposures are summarized and the potential mechanisms underlying the observed redox balance changes are examined.
Abstract: Increased oxidative stress, defined as an imbalance between prooxidants and antioxidants, resulting in molecular damage and disruption of redox signaling, is associated with numerous pathophysiological processes and known to exacerbate chronic diseases. Prolonged systemic hypoxia, induced either by exposure to terrestrial altitude or a reduction in ambient O2 availability is known to elicit oxidative stress and thereby alter redox balance in healthy humans. The redox balance modulation is also highly dependent on the level of physical activity. For example, both high-intensity exercise and inactivity, representing the two ends of the physical activity spectrum, are known to promote oxidative stress. Numerous to-date studies indicate that hypoxia and exercise can exert additive influence upon redox balance alterations. However, recent evidence suggests that moderate physical activity can attenuate altitude/hypoxia-induced oxidative stress during long-term hypoxic exposure. The purpose of this review is to summarize recent findings on hypoxia-related oxidative stress modulation by different activity levels during prolonged hypoxic exposures and examine the potential mechanisms underlying the observed redox balance changes. The paper also explores the applicability of moderate activity as a strategy for attenuating hypoxia-related oxidative stress. Moreover, the potential of such moderate intensity activities used to counteract inactivity-related oxidative stress, often encountered in pathological, elderly and obese populations is also discussed. Finally, future research directions for investigating interactive effects of altitude/hypoxia and exercise on oxidative stress are proposed.
93 citations
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TL;DR: In this paper, the authors consider the impossibilities, uncertainties and undefined relationships that may be involved in extending scientific and humanistic interest towards the development of nanosciences and nanotechnologies.
93 citations
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TL;DR: It is demonstrated that there is a synergy between gold nanoparticles and cold atmospheric plasma in cancer therapy, and the concentration of AuNPs plays an important role on plasma therapy.
Abstract: Gold nanoparticles (AuNPs) have been investigated as a promising reagent for cancer therapy in various fields. In the meantime, cold atmospheric plasma has shown exquisite selectivity towards cancer cells. In this paper, we demonstrate that there is a synergy between gold nanoparticles and cold atmospheric plasma in cancer therapy. Specifically, the concentration of AuNPs plays an important role on plasma therapy. At an optimal concentration, gold nanoparticles can significantly induce glioblastoma (U87) cell death up to a 30% overall increase compared to the control group with the same plasma dosage but no AuNPs applied. The reactive oxygen species (ROS) intensity of the corresponding conditions has a reversed trend compared to cell viability. This matches with the theory that intracellular ROS accumulation results in oxidative stress, which further changes the intracellular pathways, causing damage to the proteins, lipids and DNA. Our results show that this synergy has great potential in improving the efficiency of cancer therapy and reducing harm to normal cells.
93 citations
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TL;DR: The location of the sensitive group of the drug-molecule in a carrier system is crucial for its stability, and high stability is obtained in systems in which this part is exposed to a less polar environment.
93 citations
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TL;DR: In this article, the magnetization reversals of exchange-coupled and exchange-decoupled Nd-Fe-B sintered magnets with coercivities of 1.16 and 1.80 T, respectively, were observed by magneto-optical Kerr effect (MOKE) microscopy.
93 citations
Authors
Showing all 3879 results
Name | H-index | Papers | Citations |
---|---|---|---|
Vladimir Cindro | 129 | 1157 | 82000 |
Igor Mandić | 128 | 1065 | 79498 |
Jure Leskovec | 127 | 473 | 89014 |
Matej Orešič | 82 | 352 | 26830 |
P. Križan | 78 | 749 | 26408 |
Jose Miguel Miranda | 76 | 336 | 18080 |
Vito Turk | 74 | 271 | 23205 |
Andrii Tykhonov | 73 | 270 | 24864 |
Masashi Yokoyama | 73 | 310 | 18817 |
Kostya Ostrikov | 72 | 763 | 21442 |
M. Starič | 71 | 530 | 19136 |
Boris Turk | 67 | 231 | 27006 |
Bostjan Kobe | 66 | 279 | 17592 |
Jure Zupan | 61 | 228 | 12054 |
Mario Sannino | 60 | 281 | 17144 |