Kadi Sarva Vishwavidyalaya

About: Kadi Sarva Vishwavidyalaya is a education organization based out in Gandhinagar, Gujarat, India. It is known for research contribution in the topics: Matrix (chemical analysis) & Liquid chromatography–mass spectrometry. The organization has 131 authors who have published 158 publications receiving 1343 citations.

Brexpiprazole–catechol cocrystal: structure elucidation, excipient compatibility and stability

Abstract: Brexpiprazole (BREX) is a well known drug used in the treatment of atypical psychotic disorder. BREX is known to exhibit photo-instability on granulation with the most commonly used binder, polyvinylpyrrolidone (PVP), in wet granulation. The present study reports a cocrystal of BREX with catechol (CAT), its structure elucidation using single crystal X-ray diffraction and its processability. The brexpiprazole–catechol (BRC) cocrystal crystallizes in the P21/c space group. Structural analysis of BRC shows R22(8) between BREX and CAT through weak C–H⋯O and strong O–H⋯O hydrogen bond interactions. BREX is marketed in tablet dosage form. The compatibility of the generated cocrystal in the presence of several excipients was evaluated using differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). The cocrystal remained stable, with no signs of incompatibility during the excipient compatibility study. Additionally, the cocrystal and plain BREX granulated with PVP as a binder and the chemical stability of the granules were investigated. Plain BREX showed oxidative degradation and formation of N-oxide degradation products under stability conditions within 7 days. More importantly, the BRC cocrystal displayed superior stability against stability conditions because the reactive site in the piperazine ring of the BREX moiety was blocked in the BRC cocrystal due to the hydrogen bond between the drug and co-former.

Innovation of novel 'Tab in Tab' system for release modulation of milnacipran HCl: optimization, formulation and in vitro investigations.

Abstract: The study was aimed toward development of modified release oral drug delivery system for highly water soluble drug, Milnacipran HCl (MH). Novel Tablet in Tablet system (TITs) comprising immediate and extended release dose of MH in different parts was fabricated. The outer shell was composed of admixture of MH, lactose and novel herbal disintegrant obtained from seeds of Lepidium sativum. In the inner core, MH was matrixed with blend of hydrophilic (Benecel®) and hydrophobic (Compritol®) polymers. 32 full factorial design and an artificial neuron network (ANN) were employed for correlating effect of independent variables on dependent variables. The TITs were characterized for pharmacopoeial specifications, in vitro drug release, SEM, drug release kinetics and FTIR study. The release pattern of MH from batch A10 containing 25.17% w/w Benecel® and 8.21% w/w of Compritol® exhibited drug release pattern close proximal to the ideal theoretical profile (t50% = 5.92 h, t75% = 11.9 h, t90% = 18.11 h). The phenomen...

The influence of consumer perception towards green advertising on green purchase intention

Abstract: With the increase in the level of consumer awareness towards green products, “Green Marketing” has started gaining importance since 1970s but getting further momentum since last two decades. Many companies have added and/or modified their products and process in order to position themselves as Green. Marketers have directed their focus on advertising as the best communication tool for addressing their environmental concern and changing consumer perception by building green image. Hence, the effect of consumer perception on green purchase behaviour has a major role on companies‟ strategic orientation. Numbers of researches have been carried out to study the influence of perception towards green advertising on purchase intention that suggests the aspect of advertising to bank upon. The aim of this paper is to examine the influence of consumer perception towards green advertising on green purchase intention. In this study, perception of consumers towards green advertisements and purchase intention was measured using relevant variables identified from literature on Likert scale and using factor analysis the data was reduced and correlated. Multiple regression analysis was used to study the influence of perception on purchase intention. The results demonstrated that within consumer perception; environmental knowledge, company image, improved product features, and ethical impact have significant positive influences on green purchase intention while scepticism towards green claims and credibility have insignificant effect on green purchase intention. The outcome identified aspects of green advertising that marketers may use while designing advertising strategies.

Effective Delivery Routes And Strategies For Solid Lipid Nanoparticles (Sln) And Nanostructured Lipid Carriers (Nlc).

Abstract: Background SLNs and NLCs have remarkably wide range of properties which make them useful for several potential applications in drug delivery, clinical medicine, and research, as well as in parenteral, dermal, pulmonary and topical delivery of drugs. The unique size-dependent properties of the solid lipid nanoparticles make them at the forefront of the rapidly developing field of nanotechnology offering development of new therapeutics having reduced toxic side effects and increased treatment efficacy. Methods SLNs and NLCs are very attractive drug delivery candidates, primarily due to their relatively stable constituents and probable ease of drug encapsulations. The incorporation of drugs into nanocarriers like SLNs and NLCs for several levels of drug targeting offers good potential in gene transfer, cosmetic and food industry with great promise for reaching the goal of controlled and site-specific drug delivery. Lipid nanoparticle drug delivery technology presents considerable opportunities for improving medical therapeutics, but the technology's potential remains unrealized. Results The review has focused on the various effective delivery routes and strategies for SLNs and NLCs, and their applicability in the encapsulation of therapeutics. Number of research works has been successfully carried out in this area. It would result in a simultaneous improvement in the quality, efficacy, and safety profile of drugs. Conclusion However, because of mentioned limitations and difficulties related to them, the total number of products on the market is still limited. Although the concept of PEGylation to increase half-life of nanoparticles revolutionized the nanoparticle-mediated drug-delivery field, significant improvements are warranted in this area.