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Institution

Kadi Sarva Vishwavidyalaya

EducationGandhinagar, Gujarat, India
About: Kadi Sarva Vishwavidyalaya is a education organization based out in Gandhinagar, Gujarat, India. It is known for research contribution in the topics: Matrix (chemical analysis) & Liquid chromatography–mass spectrometry. The organization has 131 authors who have published 158 publications receiving 1343 citations.


Papers
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Journal ArticleDOI
TL;DR: D-optimal design was used to optimize the amount of components in liquid self nanoemulsifying drug delivery system and the optimized S-SNEDDS was found to be stable and its shelf life was finding to be 2.2 years.
Abstract: The solid-self nanoemulsifying drug delivery system (S-SNEDDS) of Amiodarone hydrochloride (AH) was prepared and evaluated. AH exhibits poor aqueous solubility (0.3-0.5 mg/ml) and therefore variable oral bioavailability. Capmul MCM, Cremophor RH-40 and Propylene glycol were identified as oil, surfactant and co-surfactant for preparing L-SNEDDS. D-optimal design was used to optimize the amount of components in liquid self nanoemulsifying drug delivery system (L-SNEDDS). Optimized AH-L-SNEDDS having 15.8 nm globule size and 99.5 %transmittance was then adsorbed on Neusilin US2 to form solid self nanoemulsifying drug delivery system (AH-SSNEDDS). AH loaded L-SNEDDS and S-SNEDDS were characterized for various physicochemical properties and solid state properties. In vitro dissolution, ex vivo drug release study and In vivo study were performed for pure AH, AH-LSNEDDS and AH-S-SNEDDS. Both AH loaded L-SNEDDS and S-SNEDDS showed more than 95% drug release in 20 min during drug release studies. In vivo study revealed that release of AH from S-SNEDDS was 2.26 times and LSNEDDS was 1.83 times higher than that from suspension when given to rabbits (p < 0.01). The optimized S-SNEDDS was found to be stable and its shelf life was found to be 2.2 years. S-SNEDDS could serve as a potential drug delivery system for AH.

12 citations

Proceedings ArticleDOI
03 Dec 2020
TL;DR: In this article, the authors have made an exhaustive study on different blockchain based self sovereign identity implementations (such as Sovrin, Uport, EverID, LifeID, Sora, SelfKey) along with its architectural components and discuss about use case of Self sovereign identity.
Abstract: The Internet has changed business, education, healthcare, banking etc. and it is the main part of technological evolution. Internet provides us a connecting world to perform our day to day life activities easily. Internet is designed in such a way that it can uniquely identify machine, not a person, on the network hence there is need to design a system that can perform entity identification on the Internet. Currently on Internet, service providers provide identity of a user with user name and password and store this information on a centralized server. These servers become honey pot for hackers to steal user’s personal identity information and service provider can utilize user identity information using data mining, artificial intelligence for economic benefits. Aim of Self sovereign identity system is to provide decentralized, user centric identity system which is controlled by identity owner that can be developed along with distributed ledger technology i.e. blockchain. In this paper, we intend to make an exhaustive study on different blockchain based self sovereign identity implementations (such as Sovrin, Uport, EverID, LifeID, Sora, SelfKey) along with its architectural components and discuss about use case of self sovereign identity.

12 citations

Journal ArticleDOI
TL;DR: In this paper, the electronic and optical properties of beryllium diphosphide (BeP2) were investigated under biaxial Lagrangian strain using density functional theory.
Abstract: Recently, the two-dimensional (2D) material beryllium diphosphide (BeP2) has attracted significant attention for potential device applications due to its Dirac semimetal state, dynamic and thermal stability, and high carrier mobility. In this work, we investigated its electronic and optical properties under biaxial Lagrangian strain using density functional theory (DFT). Electronic band gaps and effective charge carrier mass were highly sensitive to the Lagrangian strain of BeP2 monolayer. The bandgaps of BeP2 varied from 0 eV to 0.30 eV for 2% to 8% strain, where the strain range is based on the final stable condition of the system. The absorption spectra for the dielectric properties show the highest absorption peaks in the infrared (IR) region. These abundant strain-dependent studies of the BeP2 monolayer provide guidelines for its application in infrared sensors and devices.

12 citations

Journal ArticleDOI
TL;DR: In this paper, a simple, sensitive, and specific reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the quantification of Milnacipran HCl in rabbit plasma.
Abstract: A simple, sensitive, and specific reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the quantification of Milnacipran HCl in rabbit plasma. Milnacipran HCl and internal standard (IS, Venlafaxine HCl) were extracted by protein precipitation method with chloroform. The separation was performed on a HiQ sil C18 column (250 mm × 4.6 mm i.d., 5 µm). The wavelength was set at 220 nm. The mobile phase was a mixture of potassium dihydrogen phosphate buffer (0.0125 M) and acetonitrile (72:28%, v/v) with 0.20% triethylamine at a flow rate of 1.0 mL/min. The pH of the solution was adjusted to 3.65 with 0.1 M orthophosphoric acid. The calibration curve was linear over the concentration range 0.1–25 µg/mL. The intra-day and inter-day precision was ranged from 3.9 to 7.3% and 5.2 to 10.8%, respectively. Finally, this proposed method was successfully applied to rabbit pharmacokinetics study and yielded the most comprehensive data on systemic exposure of Milnacipran HCl...

12 citations

Journal ArticleDOI
TL;DR: In this paper, a remedial pathway for the process of dye degradation is proposed where the catalytic activity of Pd is faciled by the transfer of electrons from MCPTH to the metal centre.
Abstract: One-pot synthesis of palladium nanoparticles (PdNPs) has been achieved using calix[4]pyrrole hydrazide (MCPTH) as both reducing as well as capping agent. The synthetic procedure involves the use of environmentally benign water as solvent media. MCPTH-PdNPs have been characterized by using various analytical techniques. Transmission electron microscope analysis visualized the presence of well-dispersed and spherical Pd nanoparticles with an average dimension of 3–4 nm. Powder X-ray diffraction pattern portrayed the presence of face-centered cubic crystal structured PdNPs. A zeta potential value of − 26.2 mV suggests better stability of the nanoparticles. The heterogeneous catalytic activity of MCPTH-PdNPs was studied by probing the reduction of two carcinogenic azo dyes, namely, methylene blue and methyl orange in the presence of sodium borohydride. A remedial pathway for the process of dye degradation is proposed where the catalytic activity of Pd is faciled by the transfer of electrons from MCPTH to the metal centre. The mechanism for dye degradation is further substantiated by Density Functional Theory (DFT) calculations. The results of this work provide not only insight into fabrication of nanoparticles using calixarene platforms but also open new vistas to environmental remediation.

12 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20224
202144
202017
20198
20187