Kadi Sarva Vishwavidyalaya

About: Kadi Sarva Vishwavidyalaya is a education organization based out in Gandhinagar, Gujarat, India. It is known for research contribution in the topics: Matrix (chemical analysis) & Liquid chromatography–mass spectrometry. The organization has 131 authors who have published 158 publications receiving 1343 citations.

API specification for a small Grid Middleware - SCADY

Abstract: In this fast and rapidly developing IT era, Grid computing is emerging and is being used in many industries and organizations. This has opened a window of attraction for research on Grid Architecture, Middleware and Services.

Rapid and sensitive simultaneous estimation of metformin hydrochloride and pioglitazone hydrochloride in tablet formulation by hptlc method

Abstract: A rapid, simple, and sensitive HPTLC method for simultaneous estimation of two antidiabetic drugs, metformin hydrochloride and pioglitazone hydrochloride, in pharmaceutical tablet was developed and validated. Separation was achieved on aluminum sheets of silica gel 60 F254 using butanol:1, 4-dioxane:glacial acetic acid (5:3:2, v/v/v) as the mobile phase. This system gave a good resolution for metformin hydrochloride (R f value of 0.36 ± 0.01) and pioglitazone hydrochloride (R f value of 0.73 ± 0.01). Detection and quantification was carried out at 226 nm. Calibration plot was constructed in the range of 2000 to 20000 ng/band for metformin hydrochloride and 60 to 600 ng/band for pioglitazone hydrochloride. The linear regression data for the calibration plot showed a good relationship with r = 0.9960 and 0.9968 for metformin hydrochloride and pioglitazone hydrochloride, respectively. Assays for metformin hydrochloride and pioglitazone hydrochloride were 99.6% (RSD 0.618%) and 99.7% (RSD 0.511%), respectivel...

Quantitative determination of milnacipran HCl in rabbit plasma by HPLC and its application to pharmacokinetics study.

Abstract: A simple, sensitive, and specific reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the quantification of Milnacipran HCl in rabbit plasma. Milnacipran HCl and internal standard (IS, Venlafaxine HCl) were extracted by protein precipitation method with chloroform. The separation was performed on a HiQ sil C18 column (250 mm × 4.6 mm i.d., 5 µm). The wavelength was set at 220 nm. The mobile phase was a mixture of potassium dihydrogen phosphate buffer (0.0125 M) and acetonitrile (72:28%, v/v) with 0.20% triethylamine at a flow rate of 1.0 mL/min. The pH of the solution was adjusted to 3.65 with 0.1 M orthophosphoric acid. The calibration curve was linear over the concentration range 0.1-25 µg/mL. The intra-day and inter-day precision was ranged from 3.9 to 7.3% and 5.2 to 10.8%, respectively. Finally, this proposed method was successfully applied to rabbit pharmacokinetics study and yielded the most comprehensive data on systemic exposure of Milnacipran HCl to date.