Kadi Sarva Vishwavidyalaya

About: Kadi Sarva Vishwavidyalaya is a education organization based out in Gandhinagar, Gujarat, India. It is known for research contribution in the topics: Matrix (chemical analysis) & Mass spectrometry. The organization has 131 authors who have published 158 publications receiving 1343 citations.

Ex vivo conversion of prodrug prothionamide to its metabolite prothionamide sulfoxide with different extraction techniques and their estimation in human plasma by LC-MS/MS.

Abstract: Background: The present work reports an ex vivo conversion study of prothionamide to its active metabolite prothionamide sulfoxide in human plasma during sample preparation by three conventional extraction techniques. Results: The chromatography was done on a Hypersil™ Gold C18 (50 × 2.1 mm, 3.0 µm) column using 0.1% acetic acid and acetonitrile (20:80, v/v) as the mobile phase. Quantitation of the analytes was done by MS/MS in the positive ionization mode. The method was validated over a wide concentration range of 30 to 6000 ng/ml for prothionamide and 50 to 10,000 ng/ml for prothionamide sulfoxide. The recovery for both the analytes was greater than 89%. Stability was extensively validated under different storage conditions. Conclusion: The extraction protocol was optimized using acetonitrile as protein precipitant for their simultaneous determination in human plasma by LC–MS/MS. The method was applied to a bioequivalence study of 250 mg prothionamide tablet formulation in 14 healthy Indian subjects.

A Study of Co Movement and Interdependence of Indian Stock Market with Selected Stock Markets

Abstract: The Bombay stock exchange, Hong Kong Stock Exchange, Tokyo Stock Exchange & Shanghai Stock Exchange are among the oldest exchanges in Asia. The Study was carried out with objective to examine the causal linkages among equity markets to better understand how shocks in one market are transmitted to other markets. The study was done by taking data from 1/3/2000 to till 4/6/2011. The study was done by taking stock price data of BSE, HANGSENG, TSE & SSE. Various analytical tools such as correlation, unit root test (ADF test) and granger causality test were applied in study to find co movement & dependency of Indian market over selected markets. The correlation of daily prices gives an outcome that BSE is highly correlated with Hangseng & SSE. The granger causality test reveals an outcome that BSE is not granger cause by any of the selected market. Over all it can conclude that the selected markets are not much depending on each other.

1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-Oxide Hexafluorophosphate (HATU)/Hydroxybenzotriazole (HOBT)-based One-Pot Cyclization of N-Substituted 2-Arylbenzimidazole Derivatives

Abstract: A simple one-pot synthesis of N-substituted benzimidazoles from aromatic carboxylic acids and aromatic 1,2-diamines in the presence of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate/hydroxybenzotriazole (HATU/HOBT) and N,N-diisopropylethylamine in DMF at 100°C, featuring good to excellent yields and easy workup, is developed The protocol can be scaled to gram quantities, and no chromatographic purification is required

Query Optimizer for the ETL Process in Data Warehouses

Abstract: ETL (Extraction-Transformation-Loading) process is responsible for extracting data from several sources, cleansing, transforming, integrating and loading into a data warehouse Extraction process accesses large amount of data by executing several complex queries in source databases These queries are repetitive and executed at regular interval to refresh the data warehouse Extraction of data from source must be completed in a certain time window; hence it is necessary to optimize its execution time In this paper, we delve into the optimization of queries by recommending indices which reduces cost of the queries and improves performance of the queries