Kadi Sarva Vishwavidyalaya

About: Kadi Sarva Vishwavidyalaya is a education organization based out in Gandhinagar, Gujarat, India. It is known for research contribution in the topics: Matrix (chemical analysis) & Liquid chromatography–mass spectrometry. The organization has 131 authors who have published 158 publications receiving 1343 citations.

Systematic evaluation of plasma phospholipids for reliable and precise determination of dronedarone and desbutyldronedarone by LC-MS/MS.

Abstract: Background: The objective of the present work was to minimize or eliminate the matrix effect due to plasma phospholipids as observed during sample preparation for accurate determination of dronedarone and its active metabolite, desbutyldronedarone by LC–ESI-MS/MS. Results: The extraction recovery and matrix factors ranged from 93.27 to 95.14% and 0.99 to 1.02, respectively, for both the analytes. A linear concentration range of 0.10 to 150 ng/ml was established for both the analytes. The analytes were efficiently resolved (Rs 2.37) on Kromasil® (AkzoNobel, Bohus, Sweden) C18 column within 3.0 min. The assay reproducibility was determined by reanalysis of 72 incurred samples with % change within ±10%. Conclusion: The optimized solid-phase extraction provided cleaner extracts with reduced matrix effect from plasma phospholipids compared with protein precipitation and liquid–liquid extraction.

Evaluation of Efficacy and Safety of Artemisinin Derivatives Comparison with Quinine in Paediatric Population for Treatment of Severe Malaria: A Meta-Analysis Approach

Abstract: Artemisinin and its derivatives such as artesunate, arteether and artemether are the primary and effective treatment of choice as per WHO malaria treatment guideline for the treatment of severe malaria although various endemic countries are using quinine for the treatment of severe malaria. The objective of this meta-analysis was to evaluate the efficacy and safety of artemisinin and its derivatives compared with quinine as parenteral antimalarial therapy for treating severe malaria in children. From the year 1990 to the year 2015, studies were identified using database searches, citation searches of selected articles. The electronic databases searched engines: Pubmed, Web of Science, Global Health, Medline & Cochrane review of Journals up to April 2015. We selected published randomized controlled clinical trials (RCTs) information comparing artemisinin derivatives with quinine and route of administration was either intravenous or intramuscular for treatment of severe malaria in paediatric population as per WHO malaria treatment guideline, any gender, age group up to 15 years of children who were diagnosed with confirmed malaria by RDT or slide test. The primary outcome was efficacy in terms of parasite clearance time (PCT) and fever clearance time (FCT) in paediatrics population. The secondary outcome was the mortality, coma resolution time (CRT) and neurological sequelae at the time of discharge in the paediatric population. We assessed identified articles on the basis of clinical trial eligibility, the risk of bias and extracted data as per objective of this research for the desired outcomes. We measured 95% confidence interval by the using of REVMAN software version 5.3 for meta-analysis and summarized the collected data on the basis of characteristics of inclusion criteria of articles such as risk ratio (RR) for dichotomous outcomes and mean difference (MD) for continuous outcomes. We included total 17 RCTs, enrolling 7220 paediatric patients who were suffering from severe or complicated malaria and these trials were conducted in various countries in the world. Artemisinin derivatives showed mean PCT (MD -8.53 hours, 95% CI -9.44 to -7.62) and mean FCT (MD -9.42 hours, 95% CI -11.12 to -7.71) shorter and statistically significant (P<0.00001) as compared with quinine therapy. We evaluated secondary outcomes mortality, mean coma resolution time (CRT) and the risk of neurological sequelae at the time of discharge in paediatric malaria patients which was observed; (RR 0.82, 95% CI 0.72 to 0.93; 17 trials, 7220 participants, P=0.002), (MD -5.37 hours, 95% CI -7.70 to -3.05; nine trials, 591 participants, P<0.00001) and (RR 1.07, 95% CI 0.89 to 1.28; nine trials, 5939 participants, P=0.49), respectively. This meta-analysis of RCT addresses the evidence for various aspects in the treatment of severe malaria in the paediatric population although limitation of availability of published information in studies furthermore research on paediatric malaria population is required to overcome from challenges drug resistance, patient compliance and less adverse effect.

Novel ester derivative of cinnamates with different long alkoxy chain: synthesis, mesomorphic properties, biological evaluation

Abstract: Abstract A novel series of liquid crystals involving cinnamate-based mesogenic units interlinked between aromatic ester and alkyl bromide were designed and synthesized. All target molecules were confirmed by IR, 1H NMR, 13C NMR, ESI-MS, and elemental analysis. The mesomorphic behavior of novel synthesized materials (P1–P18), (V1–V18), and (M1–M18) was investigated through a polarizing optical microscope, differential scanning calorimetry, and thermogravimetric analysis (TGA) analysis. The lower carbon chain substituted member showed nematic phase while compound possess higher carbon chain exhibited only SmC phase. Thermal stability is determined by TGA analysis. All the cinnamate derivatives were screened for their anti-microbial, anti-malarial, and anti-tuberculosis potency. Among them, most of the derivatives exhibited outstanding anti-bacterial and anti-tuberculosis activity. Some derivatives also exhibited potent anti-fungal activity.

Barriers Influencing Adoption of Green Homes

Abstract: A green building is a building designed and constructed using the process and resources that will not compromise with the health of the environment as well as the building’s occupants, workers, general public and future generations. Due to rising awareness for issues like global warming, governments and the public all around the world now perceive the need for more sustainable building products and practices. However, the rate of adoption of such practices is very slow. This research paper identifies barriers to more widespread adoption of sustainable building practices. The data presented are mainly derived from responses to a questionnaire that was developed for this purpose. The primary barriers, identified using factor analysis include lack of awareness, lack of cost savings and lack of reliability. The work concludes that the people needs to be educated to understand the long term economic and environmental benefits for adopting the green homes.