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Institution

Kadi Sarva Vishwavidyalaya

EducationGandhinagar, Gujarat, India
About: Kadi Sarva Vishwavidyalaya is a education organization based out in Gandhinagar, Gujarat, India. It is known for research contribution in the topics: Matrix (chemical analysis) & Liquid chromatography–mass spectrometry. The organization has 131 authors who have published 158 publications receiving 1343 citations.


Papers
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Journal ArticleDOI
TL;DR: Microemulsion-based itraconazole gel (MBGI) showed better penetration and retention in human skin as well as bovine hoof as compared to commercial preparation (market formulation, MFI).
Abstract: Onychomycosis is the most common nail disease affecting nail plate and nail bed. Onychomycosis causes onycholysis which creates cavity between the nail plate and nail bed, where drug formulations could be applied, providing a direct contact of drug with the nail bed facilitating drug delivery on the infected area. The purpose of the present study was to design and evaluate the potential of microemulsion-based gel as colloidal carrier for itraconazole for delivery into onycholytic nails for effective treatment of onychomycosis. Itraconazole-loaded microemulsions were prepared and optimized using D-optimal design. The microemulsion containing 6.24 % oil, 36 % Smix, and 57.76 % water was selected as the optimized batch (MEI). The globule size and drug loading of the optimized batch were 48.2 nm and 12.13 mg/ml, respectively. Diffused reflectance FTIR studies were performed to study drug–excipient incompatibility. Ex vivo permeation studies were carried out using bovine hoof and human cadaver skin as models for nail plate and nail bed, respectively. Microemulsion-based itraconazole gel (MBGI) showed better penetration and retention in human skin as well as bovine hoof as compared to commercial preparation (market formulation, MFI). The cumulative amount of itraconazole permeated from the MBGI after 12 h was 73.39 ± 3.55 μg cm−2 which was 1.8 times more than MF. MBGI showed significantly higher ex vivo antifungal activity (P < 0.05) against Candida albicans and Trichophyton rubrum when compared to MFI. Stability studies showed that MBGI was stable at refrigeration and room temperature for 3 months. It was concluded that drug-loaded gel could be a promising formulation for effective treatment of onychomycosis.

27 citations

Journal ArticleDOI
TL;DR: It was showed that antitubercular activity of novel hydrazone derivatives of eugenol is strongly connected with the position of the substituent on aromatic aldehyde or ketones.

26 citations

Journal ArticleDOI
25 Jun 2015
TL;DR: The present study concludes that AQ is not influenced by gender, stream of education and family factors, rather it was seen to be influenced by the type of schools.
Abstract: The present research was conducted to understand the Adversity Quotient (AQ) of students who are going to enter into higher education. Higher secondary is the stage from where they move from school to higher education. So, the present research was conducted to study the AQ of 11th standard, English medium school students in Gandhinagar city, Gujarat with reference to various variables. The study was conducted on a sample of 461 boys and girls of 11 th standard school students from Gujarat State Board of Education (GSEB) and Central Board of Secondary Education (CBSE) schools. A self-constructed AQ scale was used to collect data from the students. The collected data was analyzed using statistical techniques like mean, SD and C.R values. Result revealed that there was no significant difference in the mean scores of AQ on the basis of gender, stream of education i.e. Commerce, Science and Arts, and various family variables like nature of the family, size of the family, qualification of parents, parents‟ working status and parents‟ occupation. However, a significant difference was found in the mean scores of AQ of students on the basis of board of School i.e. GSEB and CBSE. The present study concludes that AQ is not influenced by gender, stream of education and family factors, rather it was seen to be influenced by the type of schools. Investigator inquired and understood the AQ profile of higher secondary school students as it is the gate way to higher Education. By understanding the AQ levels of students, the faculty and staffs can be better equipped to support students as they navigate the stressors of college life.

26 citations

Journal ArticleDOI
TL;DR: A simple, precise and rapid ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of darunavir, a protease inhibitor, using dar unavir-d9 as internal standard (IS).

24 citations

Journal ArticleDOI
TL;DR: A sensitive, selective and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and successfully applied to a bioequivalence study of 150 mg BUP (test and reference) extended release tablet formulation in 12 healthy Indian male subjects under fed conditions.
Abstract: A sensitive, selective and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of bupropion (BUP) and its major active metabolite hydroxybupropion (HBUP) in human plasma. Separation of both the analytes and venlafaxine as internal standard (IS) from 50 μL human plasma was carried out by solid-phase extraction. The chromatographic separation of the analytes was achieved on a Zorbax Eclipse XDB C18 (150 × 4.6 mm, 5 µm) analytical column using isocratic mobile phase consisting of 20 mm ammonium acetate–methanol (10:90, v/v), with a resolution factor of 3.5. The method was validated over a wide dynamic concentration range of 0.1–350 ng/mL for BUP and 0.1–600 ng/mL for HBUP. The matrix effect was assessed by post-column infusion and the mean process efficiency was 96.08 and 94.40% for BUP and HBUP, respectively. The method was successfully applied to a bioequivalence study of 150 mg BUP (test and reference) extended release tablet formulation in 12 healthy Indian male subjects under fed conditions. Copyright © 2011 John Wiley & Sons, Ltd.

22 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20224
202144
202017
20198
20187