Institution
Karolinska Institutet
Education•Stockholm, Sweden•
About: Karolinska Institutet is a education organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 46212 authors who have published 121142 publications receiving 6008130 citations.
Topics: Population, Cancer, Poison control, Cohort study, Health care
Papers published on a yearly basis
Papers
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TL;DR: The frequency of cholangiocarcinoma is 13% and the risk of hepatobiliary carcinoma is constant after the first year after PSC diagnosis with an incidence rate of 1.5% per year, suggestive of an increased risk of pancreatic carcinoma in patients with PSC.
626 citations
TL;DR: Comparison of conventionally housed and germ-free NMRI mice revealed that production of fucosylated glycoconjugates and an α1,2-fucOSyltransferase messenger RNA in the small-intestinal epithelium requires the normal microflora.
Abstract: The maintenance and significance of the complex populations of microbes present in the mammalian intestine are poorly understood. Comparison of conventionally housed and germ-free NMRI mice revealed that production of fucosylated glycoconjugates and an α1,2-fucosyltransferase messenger RNA in the small-intestinal epithelium requires the normal microflora. Colonization of germ-free mice with Bacteroides thetaiotaomicron, a component of this flora, restored the fucosylation program, whereas an isogenic strain carrying a transposon insertion that disrupts its ability to use L-fucose as a carbon source did not. Simplified models such as this should aid the study of open microbial ecosystems.
626 citations
TL;DR: A cooperative transition from disordered to helical structure is observed as the peptide concentration is increased, consistent with formation of an oligomer, and the extent of α-helicity correlates with the antibacterial activity of LL-37 against both Gram-positive and Gram-negative bacteria.
626 citations
TL;DR: It is suggested that blockade of 5-HT re-uptake is involved in the mood-elevating action of tricyclic antidepressants, whereas blockade of noradrenaline re-ptake promotes drive in the depressed patient.
625 citations
TL;DR: Human metaphase chromosomes from blood cultures, treated with quinacrine mustard, show a banded pattern of fluorescence, which in the chromosomes with the most strongly fluorescent regions (3, 13–15 and Y) was found to be constant and reproducible.
625 citations
Authors
Showing all 46522 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Meir J. Stampfer | 277 | 1414 | 283776 |
| Albert Hofman | 267 | 2530 | 321405 |
| Guido Kroemer | 236 | 1404 | 246571 |
| Eric B. Rimm | 196 | 988 | 147119 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Jing Wang | 184 | 4046 | 202769 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| John Hardy | 177 | 1178 | 171694 |
| Marc G. Caron | 173 | 674 | 99802 |
| Ramachandran S. Vasan | 172 | 1100 | 138108 |
| Adrian L. Harris | 170 | 1084 | 120365 |
| Douglas F. Easton | 165 | 844 | 113809 |
| Zulfiqar A Bhutta | 165 | 1231 | 169329 |
| Judah Folkman | 165 | 499 | 148611 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |