Institution
Karolinska Institutet
Education•Stockholm, Sweden•
About: Karolinska Institutet is a education organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Poison control. The organization has 46212 authors who have published 121142 publications receiving 6008130 citations.
Topics: Population, Poison control, Cancer, Cohort study, Breast cancer
Papers published on a yearly basis
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Utrecht University1, University of Copenhagen2, University of Düsseldorf3, University of Ulm4, National and Kapodistrian University of Athens5, Imperial College London6, University College London7, Umeå University8, National Institutes of Health9, Norwegian Institute of Public Health10, University of Oslo11, Karolinska Institutet12, Aarhus University13, University Medical Center Utrecht14, Cancer Epidemiology Unit15, Swiss Tropical and Public Health Institute16, University of Basel17, Institut Gustave Roussy18, French Institute of Health and Medical Research19, University of Washington20, University of Turin21, Basque Government22
TL;DR: In this article, the authors investigated the association between natural-cause mortality and long-term exposure to several air pollutants, such as PM2.5, nitrogen oxides, and NOx.
1,056 citations
TL;DR: It is concluded that PS1 is subject to endoproteolytic processing in vivo, and in brains of transgenic mice expressing human PS1, approximately 17 kDa and approximately 27 kDa PS1 derivatives accumulate to saturable levels, and at approximately 1:1 stoichiometry, independent of transgene-derived mRNA.
1,055 citations
TL;DR: A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
Abstract: Breast cancer is the most common cancer among women Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC) The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)) Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility
1,048 citations
TL;DR: Higher maternal weight before pregnancy increases the risk of late fetal death, although it protects against the delivery of a small-for-gestational-age infant.
Abstract: Background Obesity before pregnancy is associated with an increased risk of several adverse outcomes of pregnancy. The risk profiles among lean, normal, or mildly overweight women are not, however, well established. Methods We studied the associations between prepregnancy body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and the frequency of late fetal death, early neonatal death, preterm delivery, and delivery of a small-for-gestational-age infant in a population-based cohort of 167,750 women in Sweden in 1992 and 1993. The women were categorized as follows, according to body-mass index: lean, less than 20.0; normal, 20.0 through 24.9; overweight, 25.0 through 29.9; and obese, 30.0 or more. The estimates were adjusted for maternal age, parity, smoking, education, whether the mother was living with the father, and maternal height. Results Among nulliparous women, the odds ratios for late fetal death were increased among women with higher body-mass indexes a...
1,048 citations
TL;DR: The present results give strong evidence for the occurrence of SP in a certain population of primary sensory neurons and support earlier findings that SP may act as a transmitter or modulator in these neurons.
1,048 citations
Authors
Showing all 46522 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Meir J. Stampfer | 277 | 1414 | 283776 |
| Albert Hofman | 267 | 2530 | 321405 |
| Guido Kroemer | 236 | 1404 | 246571 |
| Eric B. Rimm | 196 | 988 | 147119 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Jing Wang | 184 | 4046 | 202769 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| John Hardy | 177 | 1178 | 171694 |
| Marc G. Caron | 173 | 674 | 99802 |
| Ramachandran S. Vasan | 172 | 1100 | 138108 |
| Adrian L. Harris | 170 | 1084 | 120365 |
| Douglas F. Easton | 165 | 844 | 113809 |
| Zulfiqar A Bhutta | 165 | 1231 | 169329 |
| Judah Folkman | 165 | 499 | 148611 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |