Katholieke Universiteit Leuven

About: Katholieke Universiteit Leuven is a education organization based out in Leuven, Belgium. It is known for research contribution in the topics: Population & Transplantation. The organization has 61109 authors who have published 176584 publications receiving 6210872 citations.

Reactive astrocyte nomenclature, definitions, and future directions

Abstract: Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.

AquaCrop — The FAO Crop Model to Simulate Yield Response to Water: II. Main Algorithms and Software Description

Abstract: The AquaCrop model was developed to replace the former FAO I&D Paper 33 procedures for the estimation of crop productivity in relation to water supply and agronomic management in a framework based on current plant physiological and soil water budgeting concepts This paper presents the software of AquaCrop for which the concepts and underlying principles are described in the companion paper (Steduto et al, 2009) Input consists of weather data, crop characteristics, and soil and management characteristics that define the environment in which the crop will develop Algorithms and calculation procedures modeling the infiltration of water, the drainage out of the root zone, the canopy and root zone development, the evaporation and transpiration rate, the biomass production, and the yield formation are presented The mechanisms of crop response to cope with water shortage are described by only a few parameters, making the underlying processes more transparent to the user AquaCrop is a menu-driven program with a well-developed user interface With the help of graphs which are updated each time step (1 d) during the simulation run, the user can track changes in soil water content, and the corresponding changes in crop development, soil evaporation and transpiration rate, biomass production, and yield development One can halt the simulation at each time step, to study the effect of changes in water related inputs, making the model particularly suitable for developing deficit irrigation strategies and scenario analysis

De Novo CNV Analysis Implicates Specific Abnormalities of Postsynaptic Signalling Complexes in the Pathogenesis of Schizophrenia

Abstract: A small number of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes to which these CNVs contribute, CNVs with large effects on risk are likely to be rapidly removed from the population by natural selection. Accordingly, such CNVs must frequently occur as recurrent de novo mutations. In a sample of 662 schizophrenia proband–parent trios, we found that rare de novo CNV mutations were significantly more frequent in cases (5.1% all cases, 5.5% family history negative) compared with 2.2% among 2623 controls, confirming the involvement of de novo CNVs in the pathogenesis of schizophrenia. Eight de novo CNVs occurred at four known schizophrenia loci (3q29, 15q11.2, 15q13.3 and 16p11.2). De novo CNVs of known pathogenic significance in other genomic disorders were also observed, including deletion at the TAR (thrombocytopenia absent radius) region on 1q21.1 and duplication at the WBS (Williams– Beuren syndrome) region at 7q11.23. Multiple de novos spanned genes encoding members of the DLG (discs large) family of membrane-associated guanylate kinases (MAGUKs) that are components of the postsynaptic density (PSD). Two de novos also affected EHMT1, a histone methyl transferase known to directly regulate DLG family members. Using a systems biology approach and merging novel CNV and proteomics data sets, systematic analysis of synaptic protein complexes showed that, compared with control CNVs, case de novos were significantly enriched for the PSD proteome (P=1.72 � 10 � 6 ). This was largely explained by enrichment for members of the N-methyl-D-aspartate receptor (NMDAR) (P=4.24 � 10 � 6 ) and neuronal activity-regulated cytoskeleton-associated protein (ARC) (P=3.78 � 10 � 8 ) postsynaptic signalling complexes. In an analysis of 18492 subjects (7907 cases and 10585 controls), case CNVs were enriched for members of the NMDAR complex (P=0.0015) but not ARC (P=0.14). Our data indicate that defects in NMDAR postsynaptic signalling and, possibly, ARC complexes, which are known to be important in synaptic plasticity and cognition, play a significant role in the pathogenesis of schizophrenia. Molecular Psychiatry (2012) 17, 142–153; doi:10.1038/mp.2011.154; published online 15 November 2011

Towards measuring anonymity

Abstract: This paper introduces an information theoretic model that allows to quantify the degree of anonymity provided by schemes for anonymous connections. It considers attackers that obtain probabilistic information about users. The degree is based on the probabilities an attacker, after observing the system, assigns to the different users of the system as being the originators of a message. As a proof of concept, the model is applied to some existing systems. The model is shown to be very useful for evaluating the level of privacy a system provides under various attack scenarios, for measuring the amount of information an attacker gets with a particular attack and for comparing different systems amongst each other.

Colloidal Suspension Rheology

Abstract: 1. Introduction to colloid science and rheology 2. Hydrodynamic effects 3. Brownian hard spheres 4. Stable colloidal suspensions 5. Non-spherical particles 6. Weakly flocculated suspensions 7. Thixotropy 8. Shear thickening 9. Rheometry of suspensions 10. Suspensions in viscoelastic media 11. Advanced topics.