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Institution

Katholieke Universiteit Leuven

EducationLeuven, Belgium
About: Katholieke Universiteit Leuven is a education organization based out in Leuven, Belgium. It is known for research contribution in the topics: Population & Transplantation. The organization has 61109 authors who have published 176584 publications receiving 6210872 citations.


Papers
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Journal ArticleDOI
TL;DR: The role of endothelial cells in inflammation and viral infection and Viral infection and inflammatory changes are discussed and novel therapeutic strategies for COVID-19 are proposed.
Abstract: On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection and inflammatory changes and propose novel therapeutic strategies. Here, Carmeliet and colleagues discuss the role of endothelial cells in inflammation and viral infection and propose novel therapeutic strategies for COVID-19.

792 citations

Journal ArticleDOI
01 Jan 1980-Placenta
TL;DR: Trophoblastic invasion of the human decidua has been studied in 48 intact uteri with pregnancies ranging from 8 to 18 weeks after the last menstrual period to find out the role played by these cells in placentation.

792 citations

Journal ArticleDOI
TL;DR: In this article, the authors used the analysis of vibration measurements as a tool for health monitoring of bridges, and the problem of separating abnormal changes from normal changes in the dynamic behaviour was identified.
Abstract: When using the analysis of vibration measurements as a tool for health monitoring of bridges, the problem arises of separating abnormal changes from normal changes in the dynamic behaviour Normal changes are caused by varying environmental conditions such as humidity, wind and most important, temperature The temperature may have an impact on the boundary conditions and the material properties Abnormal changes on the other hand are caused by a loss of stiffness somewhere along the bridge It is clear that the normal changes should not raise an alarm in the monitoring system (ie a false positive), whereas the abnormal changes may be critical for the structure's safety In the frame of the European SIMCES-project, the Z24-Bridge in Switzerland was monitored during almost one year before it was artificially damaged Black-box models are determined from the healthy-bridge data These models describe the variations of eigenfrequencies as a function of temperature New data are compared with the models If an eigenfrequency exceeds certain confidence intervals of the model, there is probably another cause than the temperature that drives the eigenfrequency variations, for instance damage Copyright © 2001 John Wiley & Sons, Ltd

788 citations

Journal ArticleDOI
TL;DR: This collection of GaN technology developments is not itself a road map but a valuable collection of global state-of-the-art GaN research that will inform the next phase of the technology as market driven requirements evolve.
Abstract: Gallium nitride (GaN) is a compound semiconductor that has tremendous potential to facilitate economic growth in a semiconductor industry that is silicon-based and currently faced with diminishing returns of performance versus cost of investment. At a material level, its high electric field strength and electron mobility have already shown tremendous potential for high frequency communications and photonic applications. Advances in growth on commercially viable large area substrates are now at the point where power conversion applications of GaN are at the cusp of commercialisation. The future for building on the work described here in ways driven by specific challenges emerging from entirely new markets and applications is very exciting. This collection of GaN technology developments is therefore not itself a road map but a valuable collection of global state-of-the-art GaN research that will inform the next phase of the technology as market driven requirements evolve. First generation production devices are igniting large new markets and applications that can only be achieved using the advantages of higher speed, low specific resistivity and low saturation switching transistors. Major investments are being made by industrial companies in a wide variety of markets exploring the use of the technology in new circuit topologies, packaging solutions and system architectures that are required to achieve and optimise the system advantages offered by GaN transistors. It is this momentum that will drive priorities for the next stages of device research gathered here.

788 citations

Journal ArticleDOI
TL;DR: The requirements and the methodological issues to be addressed for using ABPM in clinical practice are addressed, the clinical indications for ABPM suggested by the available studies are outlined in detail, and the place of home measurement of blood pressure in relation to ABPM is discussed.
Abstract: Given the increasing use of ambulatory blood pressure monitoring (ABPM) in both clinical practice and hypertension research, a group of scientists, participating in the European Society of Hypertension Working Group on blood pressure monitoring and cardiovascular variability, in year 2013 published a comprehensive position paper dealing with all aspects of the technique, based on the available scientific evidence for ABPM. The present work represents an updated schematic summary of the most important aspects related to the use of ABPM in daily practice, and is aimed at providing recommendations for proper use of this technique in a clinical setting by both specialists and practicing physicians. The present article details the requirements and the methodological issues to be addressed for using ABPM in clinical practice, The clinical indications for ABPM suggested by the available studies, among which white-coat phenomena, masked hypertension, and nocturnal hypertension, are outlined in detail, and the place of home measurement of blood pressure in relation to ABPM is discussed. The role of ABPM in pharmacological, epidemiological, and clinical research is also briefly mentioned. Finally, the implementation of ABPM in practice is considered in relation to the situation of different countries with regard to the reimbursement and the availability of ABPM in primary care practices, hospital clinics, and pharmacies.

786 citations


Authors

Showing all 61602 results

NameH-indexPapersCitations
Eugene Braunwald2301711264576
Joseph L. Goldstein207556149527
Rakesh K. Jain2001467177727
Stefan Schreiber1781233138528
Masayuki Yamamoto1711576123028
Jun Wang1661093141621
David R. Jacobs1651262113892
Klaus Müllen1642125140748
Peter Carmeliet164844122918
Hua Zhang1631503116769
William J. Sandborn1621317108564
Elliott M. Antman161716179462
Tobin J. Marks1591621111604
Ian A. Wilson15897198221
Johan Auwerx15865395779
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023307
2022857
202111,007
202010,541
20199,719
20189,532