Katholieke Universiteit Leuven

About: Katholieke Universiteit Leuven is a education organization based out in Leuven, Belgium. It is known for research contribution in the topics: Population & Transplantation. The organization has 61109 authors who have published 176584 publications receiving 6210872 citations.

Treatment of Hypertension in Patients 80 Years of Age or Older

Abstract: A b s t r ac t Background Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death. Methods We randomly assigned 3845 patients from Europe, China, Australasia, and Tunisia who were 80 years of age or older and had a sustained systolic blood pressure of 160 mm Hg or more to receive either the diuretic indapamide (sustained release, 1.5 mg) or matching placebo. The angiotensin-converting-enzyme inhibitor perindopril (2 or 4 mg), or matching placebo, was added if necessary to achieve the target blood pressure of 150/80 mm Hg. The primary end point was fatal or nonfatal stroke. Results The active-treatment group (1933 patients) and the placebo group (1912 patients) were well matched (mean age, 83.6 years; mean blood pressure while sitting, 173.0/90.8 mm Hg); 11.8% had a history of cardiovascular disease. Median follow-up was 1.8 years. At 2 years, the mean blood pressure while sitting was 15.0/6.1 mm Hg lower in the active-treatment group than in the placebo group. In an intention-to- treat analysis, active treatment was associated with a 30% reduction in the rate of fatal or nonfatal stroke (95% confidence interval (CI), −1 to 51; P = 0.06), a 39% reduc- tion in the rate of death from stroke (95% CI, 1 to 62; P = 0.05), a 21% reduction in the rate of death from any cause (95% CI, 4 to 35; P = 0.02), a 23% reduction in the rate of death from cardiovascular causes (95% CI, −1 to 40; P = 0.06), and a 64% re- duction in the rate of heart failure (95% CI, 42 to 78; P<0.001). Fewer serious adverse events were reported in the active-treatment group (358, vs. 448 in the placebo group; P = 0.001). Conclusions The results provide evidence that antihypertensive treatment with indapamide (sus- tained release), with or without perindopril, in persons 80 years of age or older is beneficial. (ClinicalTrials.gov number, NCT00122811.)

The Photodetector Array Camera and Spectrometer (PACS) on the Herschel Space Observatory

Abstract: The Photodetector Array Camera and Spectrometer (PACS) is one of the three science instruments on ESA's far infrared and submil- limetre observatory. It employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16 × 25 pixels, each, and two filled silicon bolometer arrays with 16 × 32 and 32 × 64 pixels, respectively, to perform integral-field spectroscopy and imaging photom- etry in the 60−210 μm wavelength regime. In photometry mode, it simultaneously images two bands, 60−85 μ mo r 85−125 μ ma nd 125−210 μm, over a field of view of ∼1.75 � × 3.5 � , with close to Nyquist beam sampling in each band. In spectroscopy mode, it images afi eld of 47 �� × 47 �� , resolved into 5 × 5 pixels, with an instantaneous spectral coverage of ∼ 1500 km s −1 and a spectral resolution of ∼175 km s −1 . We summarise the design of the instrument, describe observing modes, calibration, and data analysis methods, and present our current assessment of the in-orbit performance of the instrument based on the performance verification tests. PACS is fully operational, and the achieved performance is close to or better than the pre-launch predictions.

The Impact of Charging Plug-In Hybrid Electric Vehicles on a Residential Distribution Grid

Abstract: Alternative vehicles, such as plug-in hybrid electric vehicles, are becoming more popular The batteries of these plug-in hybrid electric vehicles are to be charged at home from a standard outlet or on a corporate car park These extra electrical loads have an impact on the distribution grid which is analyzed in terms of power losses and voltage deviations Without coordination of the charging, the vehicles are charged instantaneously when they are plugged in or after a fixed start delay This uncoordinated power consumption on a local scale can lead to grid problems Therefore, coordinated charging is proposed to minimize the power losses and to maximize the main grid load factor The optimal charging profile of the plug-in hybrid electric vehicles is computed by minimizing the power losses As the exact forecasting of household loads is not possible, stochastic programming is introduced Two main techniques are analyzed: quadratic and dynamic programming