Institution
Katholieke Universiteit Leuven
Education•Leuven, Belgium•
About: Katholieke Universiteit Leuven is a education organization based out in Leuven, Belgium. It is known for research contribution in the topics: Population & Transplantation. The organization has 61109 authors who have published 176584 publications receiving 6210872 citations.
Topics: Population, Transplantation, CMOS, European union, Stars
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the effect of several heat treatments on the microstructure and mechanical properties of Ti6Al4V processed by Selective Laser Melting (SLM) is studied.
1,320 citations
TL;DR: Targeted inactivation or truncation of the beta-catenin-binding cytosolic domain of the VE-cadherin gene was found to affect assembly of endothelial cells in vascular plexi, but to impair their subsequent remodeling and maturation, causing lethality at 9.5 days of gestation.
1,320 citations
TL;DR: Intracoronary transfer of autologous bone marrow cells within 24 h of optimum reperfusion therapy does not augment recovery of global LV function after myocardial infarction, but could favourably affect infarct remodelling.
1,320 citations
Stanford University1, Katholieke Universiteit Leuven2, Max Planck Society3, Brown University4, St. Jude Children's Research Hospital5, University of Zurich6, Switch7, University of Pennsylvania8, Boston University9, Vrije Universiteit Brussel10, Hungarian Academy of Sciences11, University of Debrecen12
TL;DR: A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.
1,317 citations
TL;DR: Across 234 biopsies of sun-exposed eyelid epidermis from four individuals, the burden of somatic mutations averaged two to six mutations per megabase per cell, similar to that seen in many cancers, and exhibited characteristic signatures of exposure to ultraviolet light.
Abstract: How somatic mutations accumulate in normal cells is central to understanding cancer development but is poorly understood. We performed ultradeep sequencing of 74 cancer genes in small (0.8 to 4.7 square millimeters) biopsies of normal skin. Across 234 biopsies of sun-exposed eyelid epidermis from four individuals, the burden of somatic mutations averaged two to six mutations per megabase per cell, similar to that seen in many cancers, and exhibited characteristic signatures of exposure to ultraviolet light. Remarkably, multiple cancer genes are under strong positive selection even in physiologically normal skin, including most of the key drivers of cutaneous squamous cell carcinomas. Positively selected mutations were found in 18 to 32% of normal skin cells at a density of ~140 driver mutations per square centimeter. We observed variability in the driver landscape among individuals and variability in the sizes of clonal expansions across genes. Thus, aged sun-exposed skin is a patchwork of thousands of evolving clones with over a quarter of cells carrying cancer-causing mutations while maintaining the physiological functions of epidermis.
1,312 citations
Authors
Showing all 61602 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eugene Braunwald | 230 | 1711 | 264576 |
| Joseph L. Goldstein | 207 | 556 | 149527 |
| Rakesh K. Jain | 200 | 1467 | 177727 |
| Stefan Schreiber | 178 | 1233 | 138528 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Jun Wang | 166 | 1093 | 141621 |
| David R. Jacobs | 165 | 1262 | 113892 |
| Klaus Müllen | 164 | 2125 | 140748 |
| Peter Carmeliet | 164 | 844 | 122918 |
| Hua Zhang | 163 | 1503 | 116769 |
| William J. Sandborn | 162 | 1317 | 108564 |
| Elliott M. Antman | 161 | 716 | 179462 |
| Tobin J. Marks | 159 | 1621 | 111604 |
| Ian A. Wilson | 158 | 971 | 98221 |
| Johan Auwerx | 158 | 653 | 95779 |