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Institution

Katholieke Universiteit Leuven

EducationLeuven, Belgium
About: Katholieke Universiteit Leuven is a education organization based out in Leuven, Belgium. It is known for research contribution in the topics: Population & Transplantation. The organization has 61109 authors who have published 176584 publications receiving 6210872 citations.


Papers
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Journal ArticleDOI
TL;DR: In this article, a more general differential equation was used, which now takes into account local gravity variations and the effects of convection, which turn out to be very significant for cool stars.
Abstract: Aims The complex physics of close binary stars is made even more challenging by the proximity effects that affect it Understanding the influence of these proximity effects is one of the most important tasks in theoretical stellar astrophysics It is crucial to know how the specific intensity is distributed over the stellar disk for a correct modelling of the light curves of eclipsing binaries and planetary transits To provide theoretical input for light curve modelling codes, we present new calculations of gravity- and limb-darkening coefficients for a wide range of effective temperatures, gravities, metallicities, and microturbulent velocities Methods We computed limb-darkening coefficients for several atmosphere models, which cover the transmission curves of the Kepler , CoRoT, and Spitzer space missions as well as more widely used passbands (Stromgren, Johnson-Cousins, Sloan) In addition to these computations, which were made adopting the least-square method, we also performed calculations for the bi-parametric approximations by adopting the flux conservation method to provide users with an additional tool to estimate the theoretical error bars To facilitate the modelling of the effects of tidal and rotational distortions, we computed the gravity-darkening coefficients y (λ ) using the same models of stellar atmospheres as for the limb-darkening Compared to previous work, a more general differential equation was used, which now takes into account local gravity variations and the effects of convection Results The limb-darkening coefficients were computed with a higher numerical resolution (100 μ points instead of 15 or 17, as is often used in the ATLAS models), and five equations were used to describe the specific intensities (linear, quadratic, root-square, logarithmic, and a 4-coefficient law) Concerning the gravity-darkening coefficients, the influence of the local gravity on y (λ ) is shown as well as the effects of convection, which turn out to be very significant for cool stars The results are tabulated for log g ′s ranging from 00 to 50, –50 ≤ log [M/H] ≤ +1, 2000 K ≤ T eff ≤ 50 000 K and for five values of the microturbulent velocity ATLAS and PHOENIX plane-parallel atmosphere models were used for all computations

1,199 citations

Journal ArticleDOI
TL;DR: This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
Abstract: Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 10 × 10(-4)) In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 50 × 10(-8)), 3 of which we found after conditioning on previously identified variants Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals

1,197 citations

Journal ArticleDOI
TL;DR: The methods of this paper are illustrated for RBF kernels and demonstrate how to obtain robust estimates with selection of an appropriate number of hidden units, in the case of outliers or non-Gaussian error distributions with heavy tails.

1,197 citations

Journal ArticleDOI
TL;DR: A panel to update the prior position statements on the management of type 2 diabetes in adults includes additional focus on lifestyle management and diabetes self-management education and support and efforts targeting weight loss.
Abstract: The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the prior position statements, published in 2012 and 2015, on the management of type 2 diabetes in adults. A systematic evaluation of the literature since 2014 informed new recommendations. These include additional focus on lifestyle management and diabetes self-management education and support. For those with obesity, efforts targeting weight loss, including lifestyle, medication and surgical interventions, are recommended. With regards to medication management, for patients with clinical cardiovascular disease, a sodium–glucose cotransporter-2 (SGLT2) inhibitor or a glucagon-like peptide-1 (GLP-1) receptor agonist with proven cardiovascular benefit is recommended. For patients with chronic kidney disease or clinical heart failure and atherosclerotic cardiovascular disease, an SGLT2 inhibitor with proven benefit is recommended. GLP-1 receptor agonists are generally recommended as the first injectable medication.

1,192 citations

Journal ArticleDOI
11 Feb 2016-Cell
TL;DR: Evidence supporting a long, complex cellular phase consisting of feedback and feedforward responses of astrocytes, microglia, and vasculature is reviewed.

1,191 citations


Authors

Showing all 61602 results

NameH-indexPapersCitations
Eugene Braunwald2301711264576
Joseph L. Goldstein207556149527
Rakesh K. Jain2001467177727
Stefan Schreiber1781233138528
Masayuki Yamamoto1711576123028
Jun Wang1661093141621
David R. Jacobs1651262113892
Klaus Müllen1642125140748
Peter Carmeliet164844122918
Hua Zhang1631503116769
William J. Sandborn1621317108564
Elliott M. Antman161716179462
Tobin J. Marks1591621111604
Ian A. Wilson15897198221
Johan Auwerx15865395779
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023307
2022857
202111,007
202010,541
20199,719
20189,532