Katholieke Universiteit Leuven

About: Katholieke Universiteit Leuven is a education organization based out in Leuven, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 61109 authors who have published 176584 publications receiving 6210872 citations.

Freezing of gait: Moving forward on a mysterious clinical phenomenon

Abstract: Freezing of gait (FoG) is a unique and disabling clinical phenomenon characterised by brief episodes of inability to step or by extremely short steps that typically occur on initiating gait or on turning while walking. Patients with FoG, which is a feature of parkinsonian syndromes, show variability in gait metrics between FoG episodes and a substantial reduction in step length with frequent trembling of the legs during FoG episodes. Physiological, functional imaging, and clinical-pathological studies point to disturbances in frontal cortical regions, the basal ganglia, and the midbrain locomotor region as the probable origins of FoG. Medications, deep brain stimulation, and rehabilitation techniques can alleviate symptoms of FoG in some patients, but these treatments lack efficacy in patients with advanced FoG. A better understanding of the phenomenon is needed to aid the development of effective therapeutic strategies.

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

Abstract: The mammalian sensory system is capable of discriminating thermal stimuli ranging from noxious cold to noxious heat. Principal temperature sensors belong to the TRP cation channel family, but the mechanisms underlying the marked temperature sensitivity of opening and closing ('gating') of these channels are unknown. Here we show that temperature sensing is tightly linked to voltage-dependent gating in the cold-sensitive channel TRPM8 and the heat-sensitive channel TRPV1. Both channels are activated upon depolarization, and changes in temperature result in graded shifts of their voltage-dependent activation curves. The chemical agonists menthol (TRPM8) and capsaicin (TRPV1) function as gating modifiers, shifting activation curves towards physiological membrane potentials. Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Our results suggest a simple unifying principle that explains both cold and heat sensitivity in TRP channels.

A human phenome-interactome network of protein complexes implicated in genetic disorders

Abstract: We performed a systematic, large-scale analysis of human protein complexes comprising gene products implicated in many different categories of human disease to create a phenome-interactome network. This was done by integrating quality-controlled interactions of human proteins with a validated, computationally derived phenotype similarity score, permitting identification of previously unknown complexes likely to be associated with disease. Using a phenomic ranking of protein complexes linked to human disease, we developed a Bayesian predictor that in 298 of 669 linkage intervals correctly ranks the known disease-causing protein as the top candidate, and in 870 intervals with no identified disease-causing gene, provides novel candidates implicated in disorders such as retinitis pigmentosa, epithelial ovarian cancer, inflammatory bowel disease, amyotrophic lateral sclerosis, Alzheimer disease, type 2 diabetes and coronary heart disease. Our publicly available draft of protein complexes associated with pathology comprises 506 complexes, which reveal functional relationships between disease-promoting genes that will inform future experimentation.

Gully erosion: Impacts, factors and control

Abstract: Gully erosion attracts increasing attention from scientists as reflected by two recent international meetings [Poesen and Valentin (Eds.), Catena 50 (2–4), 87–564; Li et al., 2004. Gully Erosion Under Global Change. Sichuan Science Technology Press, Chengu, China, 354 pp.]. This growing interest is associated with the increasing concern over off-site impacts caused by soil erosion at larger spatial scales than the cultivated plots. The objective of this paper is to review recent studies on impacts, factors and control of gully erosion and update the review on dgully erosion and environmental change: importance and research needsT [Poesen et al., 2003. Catena 50 (2–4), 91–134.]. For the farmers, the development of gullies leads to a loss of crop yields and available land as well as an increase of workload (i.e. labour necessary to cultivate the land). Gullies can also change the mosaic patterns between fallow and cultivated fields, enhancing hillslope erosion in a feedback loop. In addition, gullies tend to enhance drainage and accelerate aridification processes in the semi-arid zones. Fingerprinting the origin of sediments within catchments to determine the relative contributions of potential sediment sources has become essential to identify sources of potential pollution and to develop management strategies to combat soil erosion. In this respect, tracers such as carbon, nitrogen, the nuclear bomb-derived radionuclide 137 Cs, magnetics and the strontium isotopic ratio are increasingly used to fingerprint sediment. Recent studies conducted in Australia, China, Ethiopia and USA showed that the major part of the sediment in reservoirs might have come from gully erosion. Gullies not only occur in marly badlands and mountainous or hilly regions but also more globally in soils subjected to soil crusting such as loess (European belt, Chinese Loess Plateau, North America) and sandy soils (Sahelian zone, north-east Thailand) or in soils prone to piping and tunnelling such as dispersive soils. Most of the time, the gullying processes are triggered by

How informative is the mouse for human gut microbiota research

Abstract: The microbiota of the human gut is gaining broad attention owing to its association with a wide range of diseases, ranging from metabolic disorders (e.g. obesity and type 2 diabetes) to autoimmune diseases (such as inflammatory bowel disease and type 1 diabetes), cancer and even neurodevelopmental disorders (e.g. autism). Having been increasingly used in biomedical research, mice have become the model of choice for most studies in this emerging field. Mouse models allow perturbations in gut microbiota to be studied in a controlled experimental setup, and thus help in assessing causality of the complex host-microbiota interactions and in developing mechanistic hypotheses. However, pitfalls should be considered when translating gut microbiome research results from mouse models to humans. In this Special Article, we discuss the intrinsic similarities and differences that exist between the two systems, and compare the human and murine core gut microbiota based on a meta-analysis of currently available datasets. Finally, we discuss the external factors that influence the capability of mouse models to recapitulate the gut microbiota shifts associated with human diseases, and investigate which alternative model systems exist for gut microbiota research.