Kazimierz Wielki University in Bydgoszcz

About: Kazimierz Wielki University in Bydgoszcz is a education organization based out in Bydgoszcz, Poland. It is known for research contribution in the topics: Luminescence & Population. The organization has 1109 authors who have published 2923 publications receiving 19548 citations. The organization is also known as: Casimir the Great University & Uniwersytet Kazimierza Wielkiego w Bydgoszczy.

Some Effects of Corona Plasma Treatment of Polylactide/Montmorillonite Nanocomposite Films

Abstract: Influence of the unit energy (Eu) of corona discharge used for modification of pure polylactide (PLA) and polylactide nanocomposite (PLAC) containing 5 wt% of an aluminosilicate nanofiller (Cloisite 30B) on water (ΘW) and diiodomethane (ΘD) contact angles as well as on surface free energy (γs) of these polymers was studied. ΘW and ΘD as advancing contact angles were measured with use of a goniometer while γs was calculated by the Owens–Wendt method. It was found that ΘW increased with the rising Eu while ΘD remained approximately constant. Assuming Eu = const, it could be stated that the increase in γs was much more evident for PLA than for PLAC. This increase resulted practically from the change in the polar component of γs because the dispersive component for the two materials only slightly decreased with increase in Eu.

Synthesis, molecular docking, ctDNA interaction, DFT calculation and evaluation of antiproliferative and anti-Toxoplasma gondii activities of 2,4-diaminotriazine-thiazole derivatives.

Abstract: Synthesis, characterization, and investigation of antiproliferative activities against human cancer cell lines (MV4-11, MCF-7, and A549) and Toxoplasma gondii parasite of twelve novel 2,4-diaminotriazine-thiazoles are presented. The toxicity of the compounds was studied at three different cell types, normal mouse fibroblast (Balb/3T3), mouse fibroblast (L929), and human VERO cells. The structures of novel compounds were determined using 1H and 13C NMR, FAB(+)-MS, and elemental analyses. Among the derivatives, 4a–k showed very high activity against MV4-11 cell line with IC50 values between 1.13 and 3.21 µg/ml. Additionally, the cytotoxic activity of compounds 4a–k against normal mouse fibroblast Balb/3T3 cells is about 20–100 times lower than against cancer cell lines. According to our results, compounds 4a, 4b, 4d, and 4i have very strong activity against human breast carcinoma MCF-7, with IC50 values from 3.18 to 4.28 µg/ml. Moreover, diaminotriazines 4a–l showed significant anti-Toxoplasma gondii activity, with IC50 values 9–68 times lower than those observed for sulfadiazine. Molecular docking studies indicated DNA-binding site of hTopoI and hTopoII as possible anticancer targets and purine nucleoside phosphorylase as possible anti-toxoplasmosis target. Our UV–Vis spectroscopic results indicate also that diaminotriazine-thiazoles tends to interact with DNA by intercalation. Additionally, the structure and the interaction and binding energies of a model complex formed by compound 4a and two thymine molecules are investigated using quantum mechanical methods.

Effects of Short-Term Plyometric Training on Physical Performance in Male Handball Players

Abstract: The aim of this study was to compare the effects of plyometric and jump training on physical performance in young male handball players. Twenty-six young male handball players were divided into two sub-groups to perform a five-week pre-season training programme supplemented with two ground-reactive protocols with an equal number of jumping exercises referred as to ground contacts: plyometric training (PLY; n = 14) and standard jump training (CON; n = 12). Before and after training, repeated sprint ability (RSA), jumping ability (JA), maximal oxygen uptake (VO2max) and aerobic power at the anaerobic threshold (PAT) were measured. A two-factor analysis revealed significant time effects with improvements in fat mass (p = 0.012), maximal power during the incremental cycling test (p = 0.001) and PAT (p < 0.001), power decline (PDEC) and maximal power (Pmax) in the 5th repetition (p < 0.05 and p < 0.01, respectively). The training-induced changes in absolute and relative peak power in the RSA test and absolute VO2max approached significance (p = 0.06, p = 0.053 and p = 0.06). No intervention time × exercise protocol effects were observed for any indices of JA, RSA and aerobic capacity. A five-week pre-season conditioning programme supplemented with only 15 sessions of plyometric exercise did not induce any additional benefits, compared to a matched format of standard jump training, in terms of improving jumping performance and maximal power in the RSA test. Aerobic capacity and the fatigue index in RSA were maintained under these two training conditions.