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Institution

Keele University

EducationNewcastle-under-Lyme, United Kingdom
About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.


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Journal ArticleDOI
TL;DR: In this article, a detailed curve of growth analysis of the main Fe XXV/XXVI transitions in photoionized plasmas is presented, and an average spectral energy distribution for the sample sources and directly model the Fe K absorbers in the XMM-Newton spectra with the detailed Xstar photoionization code.
Abstract: X-ray absorption line spectroscopy has recently shown evidence for previously unknown Ultra-fast Outflows (UFOs) in radio-quiet active galactic nuclei (AGNs). These have been detected essentially through blueshifted Fe XXV/XXVI K-shell transitions. In the previous paper of this series we defined UFOs as those highly ionized absorbers with an outflow velocity higher than 10,000 km s–1 and assessed the statistical significance of the associated blueshifted absorption lines in a large sample of 42 local radio-quiet AGNs observed with XMM-Newton. The present paper is an extension of that work. First, we report a detailed curve of growth analysis of the main Fe XXV/XXVI transitions in photoionized plasmas. Then, we estimate an average spectral energy distribution for the sample sources and directly model the Fe K absorbers in the XMM-Newton spectra with the detailed Xstar photoionization code. We confirm that the frequency of sources in the radio-quiet sample showing UFOs is >35% and that the majority of the Fe K absorbers are indeed associated with UFOs. The outflow velocity distribution spans from ~10,000 km s–1 (~0.03c) up to ~100,000 km s–1 (~0.3c), with a peak and mean value of ~42,000 km s–1 (~0.14c). The ionization parameter is very high and in the range log ξ ~ 3-6 erg s–1 cm, with a mean value of log ξ ~ 4.2 erg s–1 cm. The associated column densities are also large, in the range N H ~ 1022-1024 cm–2, with a mean value of N H ~ 1023 cm–2. We discuss and estimate how selection effects, such as those related to the limited instrumental sensitivity at energies above 7 keV, may hamper the detection of even higher velocities and higher ionization absorbers. We argue that, overall, these results point to the presence of extremely ionized and possibly almost Compton-thick outflowing material in the innermost regions of AGNs. This also suggests that UFOs may potentially play a significant role in the expected cosmological feedback from AGNs and their study can provide important clues on the connection between accretion disks, winds, and jets.

248 citations

Journal ArticleDOI
TL;DR: Novel evidence is provided that defective adrenergic receptor signaling combined with upregulation of ATGL and suppression of HSL and AMPK signaling mediate HFD-induced alterations in lipolysis and lipid utilization in VC and SC adipocytes, which may play an important role in defective lipid mobilization and metabolism seen in diet-induced obesity.
Abstract: This study investigated the molecular mechanisms by which a high-fat diet (HFD) dysregulates lipolysis and lipid metabolism in mouse epididymal (visceral, VC) and inguinal (subcutaneous, SC) adipoc...

248 citations

Journal ArticleDOI
TL;DR: SRMH is associated with multi-item measures of mental health, self-rated health, health problems, service utilization, and service satisfaction, and should continue to be assessed as a population health measure.
Abstract: A single-item measure of self-rated mental health (SRMH) is being used increasingly in health research and population health surveys. The item asks respondents to rate their mental health on a five-point scale from excellent to poor. This scoping study presents the first known review of the SRMH literature. Electronic databases of Medline, CINAHL, PsycINFO, EMBASE and Cochrane Reviews were searched using keywords. The databases were also searched using the titles of surveys known to include the SRMH single item. The search was supplemented by manually searching the bibliographic sections of the included studies. Two independent reviewers coded articles for inclusion or exclusion based on whether articles included SRMH. Each study was coded by theme and data were extracted about study design, sample, variables, and results. Fifty-seven studies included SRMH. SRMH correlated moderately with the following mental health scales: Kessler Psychological Distress Scale, Patient Health Questionnaire, mental health subscales of the Short-Form Health Status Survey, Behaviour and Symptom Identification Scale, and World Mental Health Clinical Diagnostic Interview Schedule. However, responses to this item may differ across racial and ethnic groups. Poor SRMH was associated with poor self-rated health, physical health problems, increased health service utilization and less likelihood of being satisfied with mental health services. Poor or fair SRMH was also associated with social determinants of health, such as low socioeconomic position, weak social connections and neighbourhood stressors. Synthesis of this literature provides important information about the relationships SRMH has with other variables. SRMH is associated with multi-item measures of mental health, self-rated health, health problems, service utilization, and service satisfaction. Given these relationships and its use in epidemiologic surveys, SRMH should continue to be assessed as a population health measure. More studies need to examine relationships between SRMH and clinical mental illnesses. Longitudinal analyses should look at whether SRMH is predictive of future mental health problems.

247 citations

Journal ArticleDOI
John A. Sloboda1
TL;DR: In this article, six pianists of varying levels of experience were required to give repeated performances of a note sequence presented for sight-performance under two conditions: (a) the bar lines and beams were shifted one note to the right in comparison to condition (b) details of note duration and intensity were recorded by computer.
Abstract: Six pianists of varying levels of experience were required to give repeated performances of a note sequence presented for sight-performance under two conditions. The two conditions differed only in the location of metrical stresses signified by the notation. In condition (b) the bar-lines and beams were shifted one note to the right in comparison to condition (a). Details of note duration and intensity were recorded by computer. This allowed the discovery of significant differences in expressive treatment between the two conditions. There were significant agreements between subjects concerning the position, nature and direction of expressive variation. The more experienced players, however, made greater use of expressive variation than did the less experienced players. In a second experiment listeners were asked to identify the metre of each performance from the first experiment. They achieved greatest success at this with the most experienced player, least success with the least experienced player. A det...

247 citations

Journal ArticleDOI
TL;DR: In this article, tendinopathy of the main body of tendo Achillis was found to increase considerably with exercise, probably due to a marked rise in the negative tissue pressure.
Abstract: study, however, 31% of 58 patients with this condition did not participate in vigorous physical activity. 3 In this article, we have concentrated on tendinopathy of the main body of tendo Achillis. We have not dealt with Haglund's condition, insertional tendinopathy, or with lesions of the myotendinous junction. Anatomy. The gastrocnemius muscle merges with the soleus to form tendo Achillis. 4 It has a round upper part and is relatively flat in its distal 4 cm. Its fibres spiral through 90°, increasing the release of stored energy during locomotion. 5 Tendo Achillis is enveloped by a paratenon, originating from the deep fascia of the leg, the fascia cruris. Blood flow in the tendon increases considerably with exercise, probably due to the marked rise in the negative tissue pressure

246 citations


Authors

Showing all 11402 results

NameH-indexPapersCitations
George Davey Smith2242540248373
Simon D. M. White189795231645
James F. Wilson146677101883
Stephen O'Rahilly13852075686
Wendy Taylor131125289457
Nicola Maffulli115157059548
Georg Kresse111430244729
Patrick B. Hall11147068383
Peter T. Katzmarzyk11061856484
John F. Dovidio10946646982
Elizabeth H. Blackburn10834450726
Mary L. Phillips10542239995
Garry P. Nolan10447446025
Wayne W. Hancock10350535694
Mohamed H. Sayegh10348538540
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202344
2022155
20211,473
20201,377
20191,178
20181,106