Keele University

About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.

Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial.

Abstract: Dyslipidemia is a leading risk factor for cardiovascular disease and is also a common feature of obesity. Curcumin is a bioactive phytochemical with well-known antioxidant, anti-inflammatory, and cardioprotective properties. The present study investigated the hypolipidemic activity of curcumin in obese individuals. Participants (n = 30) were treated with curcuminoids (1 g/day), or placebo in a randomized, double-blind, placebo-controlled, crossover trial. Serum concentrations of total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, together with anthropometric parameters and high-sensitivity C-reactive protein were measured before and after each treatment period. Anthropometric parameters including weight, BMI, waist circumference, hip circumference, arm circumference, and body fat remained statistically unchanged by the end of trial (p > 0.05). As for the lipid profile parameters, serum triglycerides were significantly reduced following curcumin supplementation (p = 0.009). However, curcuminoids were not found to affect serum levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein (p > 0.05). In summary, the findings of the present study indicated that curcuminoid supplementation (1 g/day for 30 days) leads to a significant reduction in serum triglycerides concentrations but do not have a significant influence on other lipid profile parameters as well as body mass index and body fat. Copyright © 2012 John Wiley & Sons, Ltd.

Emotions and criminal justice

Abstract: During the last decade, a process of ‘emotionalization of law’ has spread around the globe, changing the criminal justice system in many ways. Anger, disgust and shame are perceived as ‘valuable barometers of social morality’ and brought back to criminal procedures. The ‘return of emotions’ to penal law and criminal justice is linked to and illuminates the moral imagination of late modern societies. This article seeks to address two facets of the ‘return of emotions’ to criminal justice. The first part explores the changes in the public sphere and in the pattern of emotional culture in late modern societies that are responsible for the reemotionalization of the penal realm. In the second part, problems that emerge in the criminal justice system are addressed. Bringing emotions back involves profound problems that go beyond the mere instrumental use of emotions in criminal justice, or a restricted perspective of ‘what works’. Three ‘core’ problems—and associated—questions are discussed: first, are emotiona...

Structures and textures in Triassic braided stream conglomerates (‘Bunter’ Pebble Beds) in the Sherwood Sandstone Group, North Staffordshire, England

Abstract: In the northern parts of the Needwood and Stafford/Eccleshall Basins, England, the Pebble Beds of the Sherwood Sandstone Group contain thick successions of texturally mature, fluvial pebble/cobble conglomerates which are organized into either horizontal or cross-stratified sets. The horizontally lying sets, generally coarser grained and more poorly sorted than the cross-bedded sets, are usually disorganized and either matrix- or clast-supported, although thin lenses of well-sorted, occasionally openwork units, interpreted as falling stage phenomena, are often present. The cross-stratified conglomerates have foresets exhibiting remarkable textural organization, with a coarse, bimodal (sometimes matrix-supported) part grading upwards or being abruptly overlain by a finer, well-sorted (occasionally openwork) part and finally capped by sandstone. These rhythmic textural changes are attributed partly to an avalanche process at high stage and partly to falling stage conditions. The most common types of vertical association are thick successions of horizontally bedded conglomerates (up to 20 m) and sequences of an upwards coarsening nature (2-12 m) in which cross-stratified sets are overlain by flat-lying sets. The environment of deposition of the gravels is interpreted as one in which water depths at high stage were greater than depths in most modern braided stream plains (proglacial or alluvial fan) but shallower than depths associated with the Pleistocene catastrophic floods from which texturally mature, giant gravel bars have been recorded. Recent braided streams with relatively confined channels and considerable bar/channel relief are better analogues. In particular, medial or mid-channel bars with a two-tier structure (subaqueous and partly emergent portions) may explain the upward-coarsening sequences in which horizontally lying conglomerates overlie cross-stratified conglomerates. The thicker sequences of horizontally stratified conglomerates represent proximal, longitudinal bar deposits. Sheets of pebbly sandstone and argillaceous sandstone lying between the conglomerates, and commonly occurring towards the top of the succession, largely represent deposition from sandwaves and dunes. Finer, interbedded, argillaceous sandstones, siltstones and mudstones are interpreted as overbank and waning-flood deposits. Basin-forming tectonism of increasing intensity probably caused the initial coarsening upwards of the lower part of the succession, whilst more stable tectonic conditions and decreasing relief on the margins of the basins and in the areas of provenance in the Midlands and the Hercynides, account for the upwards-fining of the upper part of the succession.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

Abstract: The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Evolution of foraging behavior in Drosophila by density-dependent selection.

Abstract: One of the rare examples of a single major gene underlying a naturally occurring behavioral polymorphism is the foraging locus of Drosophila melanogaster. Larvae with the rover allele, forR, have significantly longer foraging path lengths on a yeast paste than do those homozygous for the sitter allele, fors. These variants do not differ in general activity in the absence of food. The evolutionary significance of this polymorphism is not as yet understood. Here we examine the effect of high and low animal rearing densities on the larval foraging path-length phenotype and show that density-dependent natural selection produces changes in this trait. In three unrelated base populations the long path (rover) phenotype was selected for under high-density rearing conditions, whereas the short path (sitter) phenotype was selected for under low-density conditions. Genetic crosses suggested that these changes resulted from alterations in the frequency of the fors allele in the low-density-selected lines. Further experiments showed that density-dependent selection during the larval stage rather than the adult stage of development was sufficient to explain these results. Density-dependent mechanisms may be sufficient to maintain variation in rover and sitter behavior in laboratory populations.