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Institution

Keele University

EducationNewcastle-under-Lyme, United Kingdom
About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.
Topics: Population, Stars, Health care, Galaxy, Planet


Papers
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Journal ArticleDOI
TL;DR: In this paper, the local structural environments of Y/sup 3 +/ and Zr/sup 4 +/ in 18 wt% Y/sub 2/O/sub 3/-stabilized zirconia were studied using extended X-ray absorption fine structure spectroscopy over the temperature range.
Abstract: The local structural environments of Y/sup 3 +/ and Zr/sup 4 +/ in 18 wt% Y/sub 2/O/sub 3/-stabilized zirconia were studied using extended X-ray absorption fine structure spectroscopy over the temperature range - 120/sup 0/ to 770/sup 0/C. The measured cation-oxygen distances reflect those of the parent oxides, with the mean Zr-O distance 0.017 nm shorter than the mean Y-O distance. The spread in the Zr-nearest-neighbor and Zr-next-nearest-neighbor distances is considerably larger than observed for Y/sup 3 +/. This result is attributed to the anion vacancies being preferentially sited adjacent to the smaller Zr/sup 4 +/ cation which, with ensuing relaxations, permits a closer contact between Zr/sup 4 +/ and its oxygen neighbors. Thus, the structural environment of these Zr/sup 4 +/ ions resembles that of the 7-coordinated Zr/sup 4 +/ in monoclinic zirconia. Increasing the temperature of the sample results in the local structural environments of the two cations becoming more alike, suggesting that increased anionic mobility leads to an increasingly random distribution of anion vacancies.

216 citations

Journal ArticleDOI
TL;DR: antibodies to glutaraldehyde-fixed d-aspartate are used to identify electron microscopically the sites of d- aspartate accumulation in hippocampal slices and it was confirmed that most EAAT2 is in astroglia, which explains why the densities of neuronalEAAT2 are low despite high levels of mRNA in CA3 pyramidal cell bodies, but not why EAAT in terminals account for more than half of the uptake of exogenous substrate by hippocampal slice preparations

215 citations

Journal ArticleDOI
TL;DR: A comparison of DNA barcoding and morphological taxonomy in terms of their accuracy and diversity of characters employed concludes that morphology often does not work and is often nowhere near as ‘rich’ as has been argued.
Abstract: A small but vocal community of critics has questioned the epistemological value of DNA barcoding by suggesting that either it ‘cannot work’ for the identification or discovery of species or that it ignores the ‘richness’ inherent in traditional approaches. We re-examine these arguments through a comparison of DNA barcoding and morphological taxonomy in terms of their accuracy and diversity of characters employed. We conclude that morphology often does not work and that it is often nowhere near as ‘rich’ as has been argued. Morphology is particularly poor in numerous important situations, such as the association of larvae with adults and discrimination among cryptic species. The vehemence of some of the criticisms is surprising given that morphology alone is known to be inadequate to the task of species-level identification in many instances.

215 citations

Journal ArticleDOI
TL;DR: In this article, the authors provide a set of stellar evolution and nucleosynthesis calculations that apply established physics assumptions simultaneously to low and intermediate-mass and massive star models, and provide an internally consistent and comprehensive nuclear production and yield database for applications in areas such as presolar grain studies.
Abstract: We provide a set of stellar evolution and nucleosynthesis calculations that applies established physics assumptions simultaneously to low- and intermediate-mass and massive star models. Our goal is to provide an internally consistent and comprehensive nuclear production and yield database for applications in areas such as presolar grain studies. Our non-rotating models assume convective boundary mixing (CBM) where it has been adopted before. We include 8 (12) initial masses for Z = 0.01 (0.02). Models are followed either until the end of the asymptotic giant branch phase or the end of Si burning, complemented by simple analytic core-collapse supernova (SN) models with two options for fallback and shock velocities. The explosions show which pre-SN yields will most strongly be effected by the explosive nucleosynthesis. We discuss how these two explosion parameters impact the light elements and the s and p process. For low- and intermediate-mass models, our stellar yields from H to Bi include the effect of CBM at the He-intershell boundaries and the stellar evolution feedback of the mixing process that produces the ${}^{13}{\rm{C}}$ pocket. All post-processing nucleosynthesis calculations use the same nuclear reaction rate network and nuclear physics input. We provide a discussion of the nuclear production across the entire mass range organized by element group. The entirety of our stellar nucleosynthesis profile and time evolution output are available electronically, and tools to explore the data on the NuGrid VOspace hosted by the Canadian Astronomical Data Centre are introduced.

215 citations

Journal ArticleDOI
TL;DR: In this article, the biochemical and genetic mechanisms responsible for regulating the production and relative amounts of intracellular DNA precursors, describe the many outcomes of perturbations in DNA precursor levels, and discuss implications of such imbalances for sensitivity to DNA-damaging agents, population monitoring, and human diseases.
Abstract: DNA precursor pool imbalances can elicit a variety of genetic effects and modulate the genotoxicity of certain DNA-damaging agents These and other observations indicate that the control of DNA precursor concentrations is essential for the maintenance of genetic stability, and suggest that factors which offset this control may contribute to environmental mutagenesis and carcinogenesis In this article, we review the biochemical and genetic mechanisms responsible for regulating the production and relative amounts of intracellular DNA precursors, describe the many outcomes of perturbations in DNA precursor levels, and discuss implications of such imbalances for sensitivity to DNA-damaging agents, population monitoring, and human diseases

215 citations


Authors

Showing all 11402 results

NameH-indexPapersCitations
George Davey Smith2242540248373
Simon D. M. White189795231645
James F. Wilson146677101883
Stephen O'Rahilly13852075686
Wendy Taylor131125289457
Nicola Maffulli115157059548
Georg Kresse111430244729
Patrick B. Hall11147068383
Peter T. Katzmarzyk11061856484
John F. Dovidio10946646982
Elizabeth H. Blackburn10834450726
Mary L. Phillips10542239995
Garry P. Nolan10447446025
Wayne W. Hancock10350535694
Mohamed H. Sayegh10348538540
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202344
2022155
20211,473
20201,377
20191,178
20181,106