Keele University

About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.

Elevation of Visual Threshold by Displacement of Retinal Image

Abstract: THERE have been many reports that the threshold for perception of a test flash is raised during a saccadic eye movement1–4. Even with a flash brief enough to eliminate any blurring of its retinal image during the saccade, an elevation of threshold by half a log unit is common3, although there have been significant exceptions5. Of particular interest is the finding that this reduction in visibility may apply to flashes occurring as much as 40 ms before the onset of a saccade. Not unnaturally, this has been widely interpreted as evidence of some central inhibitory process, set in motion as part of the preparation of a voluntary eye movement.

Molecular genetic studies of sporadic pituitary tumors.

Abstract: Tumor formation may result from the activation of dominant oncogenes or by inactivation of recessive, tumor suppressor genes. The role of such mutations in the development of pituitary tumors has been studied. Tumors from 88 patients, representing the 4 major classes of adenoma, were investigated. In DNA extracted from matched leukocyte and tumor samples, allelic deletions were sought with 15 probes identifying restriction fragment length polymorphisms on chromosomes 1, 5, 10, 11, 13, 17, 20, and 22. Evidence of amplification or rearrangement of 10 recognized cellular oncogenes (N-ras, mycL1, mycN, myc, H-ras, bcl1, H-stf1, sea, kraS2, and fos) was sought in tumor DNA. Activating dominant mutations of Gs alpha were detected using the polymerase chain reaction to amplify exons 7-10 and hybridizing the product to normal and mutant allele-specific oligonucleotides. Allelic deletions on chromosome 11 were identified in 16 tumors (18%) representing all 4 major subtypes. Deletions on other autosomes were observ...