Keele University

About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.

European Environmental Taxes and Charges: Recent Experience, Issues and Trends

Abstract: The use of environmental taxes and charges in OECD countries increased by over 50% between 1987 and 1994. While revenues raised by environmental taxes and charges remain small relative to overall taxation, they comprise a rising proportion in most European countries. Several European countries have either undertaken or are considering systematic shifts in taxes away from labour and onto the use of environmental resources. Potential negative effects on competitiveness, and regressive distributional effects, are the major cause of concern with regard to the introduction of environmental taxes. A number of ways of mitigating such effects exist and have been implemented.

Topology and Structure of the C1q-Binding Site on C-Reactive Protein

Abstract: The host defense functions of human C-reactive protein (CRP) depend to a great extent on its ability to activate the classical complement pathway. The aim of this study was to define the topology and structure of the CRP site that binds C1q, the recognition protein of the classical pathway. We have previously reported that residue Asp 112 of CRP plays a major role in the formation of the C1q-binding site, while the neighboring Lys 114 hinders C1q binding. The three-dimensional structure of CRP shows the presence of a deep, extended cleft in each protomer on the face of the pentamer opposite that containing the phosphocholine-binding sites. Asp 112 is part of this marked cleft that is deep at its origin but becomes wider and shallower close to the inner edge of the protomer and the central pore of the pentamer. The shallow end of the pocket is bounded by the 112–114 loop, residues 86–92 (the inner loop), the C terminus of the protomer, and the C terminus of the pentraxin α-helix 169–176, particularly Tyr 175 . Mutational analysis of residues participating in the formation of this pocket demonstrates that Asp 112 and Tyr 175 are important contact residues for C1q binding, that Glu 88 influences the conformational change in C1q necessary for complement activation, and that Asn 158 and His 38 probably contribute to the correct geometry of the binding site. Thus, it appears that the pocket at the open end of the cleft is the C1q-binding site of CRP.

The changing epidemiology of gout.

Abstract: Gout is one of the most common inflammatory arthritides, which is considered to be a true crystal deposition disorder caused by the formation of monosodium urate crystals in and around joints. A number of epidemiological studies from a diverse range of countries suggest that gout has increased in prevalence and incidence in recent years and that the clinical pattern of gout is becoming more complex. In particular, the greatest increase has been observed in primary gout in older men. Robust epidemiological studies have established risk factors for gout including genetic factors, excess alcohol consumption, purine-rich diet, the metabolic syndrome (obesity, hypertension, hyperlipidemia and insulin resistance), use of diuretics and chronic renal failure. Trends in alcohol use, diet, obesity and the metabolic syndrome in the general population might explain changes in the prevalence and incidence of gout in the community. Osteoarthritis, which is thought to predispose patients to monosodium urate crystal deposition in their joints, is becoming more prevalent as a consequence of increased longevity. In hospital settings, widespread diuretic use, increasing prevalence of end-stage renal failure and the success of organ transplant programmes have led to an increase in clinical complexity. Suboptimal management of gout is likely to have contributed to the rise in the prevalence of clinically overt, symptomatic, chronic gout.