Keele University

About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.

FEELINGS AND FUNCTIONS IN THE FEAR OF CRIME Applying a New Approach to Victimisation Insecurity

Abstract: This paper presents a new definition of fear of crime that integrates two conceptual developments in this enduring field of criminological enquiry. Our measurement strategy differentiates first between specific worries and diffuse anxieties in emotional responses to crime, and second between productive and counterproductive effects on subjective well-being and precautionary activities. Drawing on data from a representative survey of seven London neighbourhoods, these distinctions are combined into an ordinal scale that moves from the ‘unworried’, to low-level motivating emotions, to frequent and dysfunctional worry about crime. We demonstrate that different categories of ‘fear’ have different correlates and explain different levels of variation in public confidence in policing. We conclude with a call for more longitudinal research to uncover the dynamic nature of fear of crime over the life course.

Contractures in orthopaedic and neurological conditions: a review of causes and treatment.

Abstract: Purpose : To examine the techniques used for the treatment of contracture in the context of current scientific knowledge of muscle. Method : Synthesis of data available from MEDLINE, RECAL, EMBASE, the Cochrane Library and relevant texts. Results : The development of contractures through immobilisation, muscle weakness and spasticity is described. The effects of passive stretching, continuous passive movement, serial plastering, splinting, electrical stimulation, botulinum injections and surgical tenotomies in the treatment of contractures in persons with neurological and orthopaedic conditions are identified. The strengths and weaknesses of these modalities are discussed. Conclusion : Predisposing factors persist after treatment of contractures thus for treatment to be effective long-term management programmes need to be developed. New treatment techniques, used in series or combined, offer the prospect of improved management of contracture. Scientific and clinical research is needed to investigate the e...

Eclipsing binaries in open clusters – III. V621 Per in χ Persei

Abstract: V621Persei is a detached eclipsing binary in the open clusterPersei which is com- posed of an early B-type giant star and a main sequence secondary component. From high-resolution spectroscopic observations and radial velocities from the literature, we determine the orbital period to be 25.5 days and the primary velocity semiamplitude to be K = 64.5 ± 0.4kms i1 . No trace of the secondary star has been found in the spectrum. We solve the discovery light curves of this totally-eclipsing binary and find that the surface gravity of the secondary star is loggB = 4.244 ± 0.054. We compare the absolute masses and radii of the two stars in the mass-radius diagram, for dier- ent possible values of the primary surface gravity, to the predictions of stellar models. We find that loggA … 3.55, in agreement with values found from fitting Balmer lines with synthetic profiles. The expected masses of the two stars are 12Mfl and 6Mfl and the expected radii are 10Rfl and 3Rfl. The primary component is near the blue loop stage in its evolution.

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.

Abstract: The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of adherence and invasion. Heparin, a widely used anticoagulant drug, is structurally similar to HS and is a common experimental proxy. Exogenous heparin prevents infection by a range of viruses, including S-associated coronavirus isolate HSR1. Here, we show that heparin inhibits severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) invasion of Vero cells by up to 80% at doses achievable through prophylaxis and, particularly relevant, within the range deliverable by nebulisation. Surface plasmon resonance and circular dichroism spectroscopy demonstrate that heparin and enoxaparin, a low-molecular-weight heparin which is a clinical anticoagulant, bind and induce a conformational change in the spike (S1) protein receptor-binding domain (S1 RBD) of SARS-CoV-2. A library of heparin derivatives and size-defined fragments were used to probe the structural basis of this interaction. Binding to the RBD is more strongly dependent on the presence of 2-O or 6-O sulfate groups than on N-sulfation and a hexasaccharide is the minimum size required for secondary structural changes to be induced in the RBD. It is likely that inhibition of viral infection arises from an overlap between the binding sites of heparin/HS on S1 RBD and that of the angiotensin-converting enzyme 2. The results suggest a route for the rapid development of a first-line therapeutic by repurposing heparin and its derivatives as antiviral agents against SARS-CoV-2 and other members of the Coronaviridae.

Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation.

Abstract: This study has assessed the relative proportions of type I and II collagens and IIA procollagen in full depth biopsies of repair tissue in a large sample of patients treated with autologous chondrocyte implantation (ACI). Sixty five full depth biopsies were obtained from knees of 58 patients 8–60 months after treatment by ACI alone (n = 55) or in combination with mosaicplasty (n = 10). In addition articular cartilage was examined from eight individuals (aged 10–50) as controls. Morphology and semi-quantitative immunohistochemistry for collagen types I and II and procollagen IIA in the repair tissue were studied. Repair cartilage thickness was 2.89 ± 1.5 mm and there was good basal integration between the repair cartilage, calcified cartilage and subchondral bone. Sixty five percent of the biopsies were predominantly fibrocartilage (mostly type I collagen and IIA procollagen), 15% were hyaline cartilage (mostly type II collagen), 17% were of mixed morphology and 3% were fibrous tissue (mostly type I collagen). Type II collagen and IIA procollagen were usually found in the lower regions near the bone and most type II collagen was present 30–60 months after treatment. The presence of type IIA procollagen in the repair tissue supports our hypothesis that this is indicative of a developing cartilage, with the ratio of type II collagen:procollagen IIA increasing from < 2% in the first two years post-treatment to 30% three to five years after treatment. This suggests that cartilage repair tissue produced following ACI treatment, is likely to take some years to mature.