Keele University

About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.

Inter-disciplinary perspectives on processes in the hyporheic zone

Abstract: The interface between groundwater and surface water within riverine/riparian ecosystems--the hyporheic zone (HZ)--is experiencing a rapid growth of research interest from a range of scientific disciplines, often with different perspectives. The majority of the multi-disciplinary research aims to elucidate HZ process dynamics and their importance for surface water and groundwater ecohydrology and biogeochemical cycling. This paper presents a critical inter-disciplinary review of recent advances of research centred on the HZ and highlights the current state of knowledge regarding hydrological, biogeochemical and ecohydrological process understanding. The spatial and temporal variability of surface water and groundwater exchange (hyporheic exchange flows), biogeochemical cycling and heat exchange (thermal regime) are considered in relation to both experimental measurements and modelling of these phenomena. We explore how this knowledge has helped to increase our understanding of HZ ecohydrology, and particularly its invertebrate community, the processing of organic matter, trophic cascading and ecosystem engineering by macrophytes and other organisms across a range of spatial and temporal scales. In addition to providing a detailed review of HZ functions, we present an inter-disciplinary perspective on how to advance and integrate HZ process understanding across traditional discipline boundaries. We therefore attempt to highlight knowledge gaps and research needs within the individual disciplines and demonstrate how innovations and advances in research, made within traditional subject-specific boundaries (e.g. hydrology, biochemistry and ecology), can be used to enhance inter-disciplinary scientific progress by cross-system comparisons and fostering of greater dialogue between scientific disciplines.

Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation

Abstract: BACKGROUND: Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. METHODS: We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. RESULTS: We observed microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism; of these samples, 4 were obtained from members of two unrelated kindreds, and 9 were from patients with sporadic cases. All the patients had disease onset during early childhood. Of the patients with gigantism who did not carry an Xq26.3 microduplication, none presented before the age of 5 years. Genomic characterization of the Xq26.3 region suggests that the microduplications are generated during chromosome replication and that they contain four protein-coding genes. Only one of these genes, GPR101, which encodes a G-protein-coupled receptor, was overexpressed in patients' pituitary lesions. We identified a recurrent GPR101 mutation (p.E308D) in 11 of 248 patients with acromegaly, with the mutation found mostly in tumors. When the mutation was transfected into rat GH3 cells, it led to increased release of growth hormone and proliferation of growth hormone-producing cells. CONCLUSIONS: We describe a pediatric disorder (which we have termed X-linked acrogigantism [X-LAG]) that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. We also found a recurrent mutation in GPR101 in some adults with acromegaly. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.).

Early Weightbearing and Ankle Mobilization after Open Repair of Acute Midsubstance Tears of the Achilles Tendon

Abstract: PurposeTo study the effects of early weightbearing and ankle mobilization after acute repair of ruptured Achilles tendon.Study DesignComparative longitudinal study.MethodsPatients in group 1 were postoperatively immobilized with their ankle in gravity equinus, they were encouraged to bear weight on the operated limb as soon as possible to full weightbearing, and they received a single cast change at 2 weeks, with the ankle accommodated in an anterior splint in a plantigrade position, allowing the ankle to be plantar flexed fully but not dorsiflexed above neutral. Patients in group 2 were immobilized with their ankle in full equinus with a cast change at 2 weeks, when the ankle was immobilized in mid equinus, and at 4 weeks, when the ankle was immobilized in a plantigrade position, and they were advised to bear weight.ResultsPatients in group 1 attended fewer outpatient visits, completely discarded their crutches at an average of 2.5 weeks, and more were satisfied with the results of surgery. At ultrasonog...

The Suzaku view of highly ionized outflows in AGN – I. Statistical detection and global absorber properties

Abstract: We present the results of a new spectroscopic study of Fe K-band absorption in Active Galactic Nuclei (AGN). Using data obtained from the Suzaku public archive we have performed a statistically driven blind search for Fexxv He and/or Fexxvi Ly absorption lines in a large sample of 51 type 1:0 1:9 AGN. Through extensive Monte Carlo simulations we nd that statistically signicant absorption is detected at E & 6:7 keV in 20/51 sources at the PMC > 95% level, which corresponds to 40% of the total sample. In all cases, individual absorption lines are detected independently and simultaneously amongst the two (or three) available XIS detectors which conrms the robustness of the line detections. The most frequently observed outow phenomenology consists of two discrete absorption troughs corresponding to Fexxv He and Fexxvi Ly at a common velocity shift. From xstar tting the mean column density and ionisation parameter for the Fe K absorption components are log(NH=cm 2 ) 23 and log(= erg cm s 1 ) 4:5, respectively. Measured outow velocities span a continuous range from < 1; 500 km s 1 up to 100; 000 km s 1 , with mean and median values of 0:1 c and 0:056 c, respectively. The results of this work are consistent with those recently obtained using XMM-Newton and independently provides strong evidence for the existence of very highly-ionised circumnuclear material in a signicant fraction of both radio-quiet and radio-loud AGN in the local universe.